Calman A. MacLennan
BM, BCh, DPhil, FHEA, FRCP, FRCPath
Professor of Vaccine Immunology (University of Birmingham)
- Jenner Investigator and Group Leader - Gonococcal Vaccine Project, Jenner Institute
- Director of BactiVac, the Bacterial Vaccines Network, Institute of Immunology and Immunotherapy, University of Birmingham, UK
- Consultant Immunologist, Oxford University Hospitals NHS Foundation Trust, UK
- Senior Program Officer, Bacterial Vaccines, Global Health, Enteric & Diarrheal Diseases, Bill & Melinda Gates Foundation, Seattle, US
Vaccinologist, Immunologist & Clinician Scientist focused on bacterial infections and AMR
Calman MacLennan is a clinician scientist, vaccinologist and immunologist who joined the Jenner Institute in 2015. For the past 25 years, his career has focused on understanding mechanisms of immunological of protection against bacterial infections of global health significance and antimicrobial resistance (AMR) concern. This knowledge has then been applied to the development of protective vaccines.
With experience of vaccine development in academia and industry, he has been involved in the development of several bacterial vaccines including one licensed vaccine against typhoid and other vaccines currently in clinical trials.
He leads the Gonococcal Vaccine Project which is using native Outer Membrane Vesicle (nOMV) technology to develop a candidate vaccine against Neisseria gonorrhoeae, the causative agent of gonorrhoea. Gonorrhoea infects 82.4 million people each year and is rapidly becoming resistant to all known antibiotics.
Professor MacLennan is the founder and director of BactiVac, the Bacterial Vaccines Network, a worldwide network based out of the University of Birmingham with a mission to accelerate the development of vaccines against bacterial pathogens as a countermeasure to AMR. He is a Consultant Immunologist at the Oxford University Hospitals NHS Foundation Trust.
Key publications
Threshold protective levels of serum IgG to Shigella lipopolysaccharide: re-analysis of Shigella vaccine trials data.
Journal article
Cohen D. et al, (2023), Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 29, 366 - 371
Impact and Control of Sugar Size in Glycoconjugate Vaccines.
Journal article
Stefanetti G. et al, (2022), Molecules (Basel, Switzerland), 27
Critical Needs in Advancing Shigella Vaccines for Global Health
Journal article
MacLennan CA. et al, (2022), The Journal of Infectious Diseases, 225, 1500 - 1503
Short Vi-polysaccharide abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM197conjugate vaccine
Journal article
Micoli F. et al, (2020), Proceedings of the National Academy of Sciences, 117, 24443 - 24449
Outer membrane vesicle vaccines
Journal article
Micoli F. and MacLennan CA., (2020), Seminars in Immunology, 50, 101433 - 101433
Comparative immunogenicity and efficacy of equivalent outer membrane vesicle and glycoconjugate vaccines against nontyphoidal Salmonella
Journal article
Micoli F. et al, (2018), Proceedings of the National Academy of Sciences, 115, 10428 - 10433
Presentation of life-threatening invasive nontyphoidal Salmonella disease in Malawian children: A prospective observational study
Journal article
MacLennan CA. et al, (2017), PLOS Neglected Tropical Diseases, 11, e0006027 - e0006027
Contribution of factor H-Binding protein sequence to the cross-reactivity of meningococcal native outer membrane vesicle vaccines with over-expressed fHbp variant group 1
Journal article
Marini A. et al, (2017), PLOS ONE, 12, e0181508 - e0181508
Cytokine Profiles in Malawian Children Presenting with Uncomplicated Malaria, Severe Malarial Anemia, and Cerebral Malaria
Journal article
Mandala WL. et al, (2017), Clinical and Vaccine Immunology, 24
A Systematic Review of the Incidence, Risk Factors and Case Fatality Rates of Invasive Nontyphoidal Salmonella (iNTS) Disease in Africa (1966 to 2014)
Journal article
Uche IV. et al, (2017), PLOS Neglected Tropical Diseases, 11, e0005118 - e0005118
Characterization of O-antigen delivered by Generalized Modules for Membrane Antigens (GMMA) vaccine candidates against nontyphoidal Salmonella
Journal article
De Benedetto G. et al, (2017), Vaccine, 35, 419 - 426
Brief Report: Immunization of HIV-Infected Adults in the UK With Haemophilus influenzae b/Meningococcal C Glycoconjugate and Pneumococcal Polysaccharide Vaccines
Journal article
MacLennan CA. et al, (2016), JAIDS Journal of Acquired Immune Deficiency Syndromes, 73, 287 - 293
Cytokine Profiles during Invasive Nontyphoidal Salmonella Disease Predict Outcome in African Children
Journal article
Gilchrist JJ. et al, (2016), Clinical and Vaccine Immunology, 23, 601 - 609
Bactericidal Immunity to Salmonella in Africans and Mechanisms Causing Its Failure in HIV Infection
Journal article
Goh YS. et al, (2016), PLOS Neglected Tropical Diseases, 10, e0004604 - e0004604
Monoclonal Antibodies of a Diverse Isotype Induced by an O-Antigen Glycoconjugate Vaccine Mediate In Vitro and In Vivo Killing of African Invasive Nontyphoidal Salmonella
Journal article
Goh YS. et al, (2015), Infection and Immunity, 83, 3722 - 3731
Genetic susceptibility to invasive Salmonella disease
Journal article
Gilchrist JJ. et al, (2015), Nature Reviews Immunology, 15, 452 - 463
Design of Glycoconjugate Vaccines against Invasive African Salmonella enterica Serovar Typhimurium
Journal article
Rondini S. et al, (2015), Infection and Immunity, 83, 996 - 1007
Vaccines against poverty
Journal article
MacLennan CA. and Saul A., (2014), Proceedings of the National Academy of Sciences, 111, 12307 - 12312
A broadly-protective vaccine against meningococcal disease in sub-Saharan Africa based on Generalized Modules for Membrane Antigens (GMMA)
Journal article
Koeberling O. et al, (2014), Vaccine, 32, 2688 - 2695
Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X
Journal article
Micoli F. et al, (2013), Proceedings of the National Academy of Sciences, 110, 19077 - 19082
Dysregulated Humoral Immunity to Nontyphoidal Salmonella in HIV-Infected African Adults
Journal article
MacLennan CA. et al, (2010), Science, 328, 508 - 512
Importance of antibody and complement for oxidative burst and killing of invasive nontyphoidalSalmonellaby blood cells in Africans
Journal article
Gondwe EN. et al, (2010), Proceedings of the National Academy of Sciences, 107, 3070 - 3075
The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children
Journal article
MacLennan CA. et al, (2008), Journal of Clinical Investigation, 118, 1553 - 1562