Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Work packages


WORK PACKAGE 1 - Controlled Human Malaria Infection Vaccine Trials in East Africa

The main objective of WP1 is to undertake clinical vaccine trials involving controlled human malaria infection (CHMI) in Kenya and Tanzania.

Clinical Trials

VAC074 - Safety, immunogenicity, and efficacy of R21/Matrix-M and ChAd63/MVA-ME-TRAP in the context of controlled human malaria infection: A Phase IIb Trial in Kenyan link

This trial started in June 2022 in Kilifi, Kenya where we are testing two components of the multi-stage malaria vaccine; R21/Matrix-M (sporozoite stage) and ME-TRAP (liver stage) in a human malaria challenge (CHMI).

VAC080 - A Phase Ib clinical trial to assess the safety and immunogenicity of the blood-stage Plasmodium falciparum malaria vaccine candidate RH5.1/Matrix-M in healthy adults and infants in Tanzania link

This trial started in January 2021 where we are testing the safety and immune response of the blood stage malaria vaccine component, RH5.1/Matrix-M in Bagamoyo, Tanzania.  The trial was fully enrolled by April 2021 and the vaccine was well tolerated by adults and children.  Immunology analysis of samples is currently underway.

VAC083 - A pilot study to assess the safety and feasibility of controlled blood-stage Plasmodium falciparum human malaria infection through experimental inoculation of cryopreserved infected erythrocytes in healthy adults with varying degrees of prior exposure to malaria link

We are establishing a blood stage malaria challenge model in the IHI facility in Tanzania which will allow us to test the efficacy of the blood-stage malaria vaccine component more accurately in people who live in a malaria endemic area.  The first blood-stage malaria CHMI took place successfully in July 2022.


WORK PACKAGE 2 - Age de-escalation phase I trials in Kenya and in The Gambia

The main objective of WP2 is to undertake age de-escalation phase I trials in Kenya and The Gambia.

 Clinical Trials

 VAC073 - A Phase 1b, open-label, age de-escalation, dose-escalation study to evaluate the safety and immunogenicity of different doses of a candidate malaria vaccine; adjuvanted R21(R21/MM) in adults, young children and infants in Kilifi, Kenya link

This trial started in April 2019 where we are testing the safety and immune response of the sporozoite stage of the multi-stage malaria vaccine, R21/Matrix-M in healthy adults, children and infants in Kilifi, Kenya.  The trial is now complete with the last volunteer last visit occurring in June 2022.  The vaccine was safe in all age groups and elicited a strong immune response which was successfully boosted after a year post primary series.

VAC086 - A Phase Ib multi-stage Plasmodium falciparum malaria vaccine study to assess the safety and immunogenicity of the blood-stage vaccine candidate RH5.2 virus-like particle (VLP) in Matrix-M and the pre-erythrocytic stage vaccine candidate R21 in Matrix-M, both alone and in combination, in adults and infants in the Gambia link

This is a multi-stage malaria vaccine trial planned to start in Q4 of 2022 to test both the sporozoite stage vaccine R21/Matrix-M and the blood-stage vaccine RH5.1/Matrix-M in both adults and infants in the Gambia.

WORK PACKAGE 3 - Phase IIb vaccine efficacy trial against clinical malaria in infants

The main objective of WP3 is to undertake a large multi-stage malaria vaccine phase II efficacy trial in 400 infants (5-9 months of age) in 3 African countries; Kenya, Sierra Leone and Burkina Faso

Clinical Trials

VAC076 - A Phase Ib/IIb randomised controlled trial of the safety, immunogenicity and efficacy of a candidate malaria vaccine, R21 adjuvanted with Matrix-M (R21/MM), in 5-17 month old children in Nanoro, Burkina Faso link

We progressed R21/Matrix-M in a larger randomised controlled clinical trial in 450 children in Nanoro, Burkina Faso.  We collected safety and immunogenicity data as well as determined how effective the vaccine is in preventing malaria.  The vaccine was safe and induced very potent antibody responses in these 5-17 month olds.  Excitingly, the vaccine trial showed important high level efficacy of 77% in preventing episodes of clinical malaria in the R21/Matrix-M vaccinated groups compared to the control group over 12 months of follow-up.  A booster vaccine given after one year later stimulated as high immune responses as were seen following the primary series of vaccinations.  The results of this trial were published recently in the Lancet. As a results of this successful booster dose we went on to boost the infants a second time.  The results of this additional booster will be published shortly.


A Phase IIb randomized efficacy field trial of a multi-stage vaccine in infants – this trial is planned to take start in 2023.

WORK PACKAGE 4 - Transmission-blocking vaccine trials

The main objectives of WP4 are to identify Burkinabe villages with high malaria transmission rates then to undertake a large malaria vaccine phase IIb efficacy trial using the transmission blocking vaccine, Pfs25-IMX313 in children, and finally, to test the impact of this vaccine on mosquito-to-human transmission in Kilifi, Kenya.

Surveillance work

To prepare for later mosquito-stage vaccine trials, large surveys took place in Bobo-Dioulasso, Burkina Faso to determine where the highest rates of malaria transmission occur.  30,000 mosquitoes were collected and dissected.  Parasite surveys also took place where monthly blood samples were taken from 100 children and the parasites quantified.  As a result of these surveys and analyses, and with respect to the transmission index, accessibility and health facilities, three villages have been identified as possible locations for the later IIb transmission blocking trial.  In parallel we are optimising laboratory tests where mosquitoes are fed potentially infectious blood samples in order to assess the infectivity of the study participants in future trials.

Clinical Trials

VAC082 - A phase Ib age de-escalation and dose escalation open label clinical trial of the safety, immunogenicity and ex vivo efficacy of a candidate malaria vaccine Pfs25-IMX313/Matrix-M administered intramuscularly in healthy adults and young children in Tanzania link

This trial started in April 2021 where we are testing the transmission blocking candidate component of the multi-stage malaria vaccine, Pfs25-IMX313/Matrix-M in adults and young children in Bagamoyo in Tanzania.  The vaccine has a good safety profile in both adults and children.  Immunoassays are on-going.  The trial is due to be complete in 2023.

A Phase IIb transmission blocking vaccine trial in children in Burkina Faso.  Planned to start in 2023

A Phase IIb human to mosquito transmission CHMI trial with a transmission blocking vaccine in Kenyan adults.  Planned to start in 2023.


WORK PACKAGE 5 - Capacity-building and Networking

The main objectives of WP5 are to undertake capacity building and to facilitate networking between consortium partners as well as support African students in short and long term training programmes

During the MMVC project, we also aim to undertake capacity building and to help networking between consortium partners, as well as support African students in training programmes.  Capacity building is taking place in IRSS-DRO, Burkina Faso where a new research facility is being developed to perform large scale laboratory analysis of blood samples.  Capacity building is also taking place in IHI, Bagamoyo to establish the blood-stage challenge model.

The consortium has appointed three PhD students and two MSc student who are undergoing training and analysing samples for their projects.

WORK PACKAGE 6 - Management and Sponsorship

The main objectives of WP6 is to set up an appropriate and effective project management framework for the project.

The University of Oxford sponsors all of the clinical trials in the MMVC.  The MMVC project management groups, the steering committee and data safety monitoring committees continue to contribute at regular meetings and ensure the successful progress of the programme.  

The Covid-19 pandemic presented many challenges in conducting medical research, however the MMVC consortium continued to make good progress while minimising risk to trial participants and consortium members.