Research groups
Colleges
Ahmed M. Salman
BSc, MSc, DPhil (Oxon)
Dr., RESEARCH GROUP LEADER, Senior Immunologist-Vaccinologist, SRF Manager
- RESEARCH GROUP LEADER
- Jenner's VLP, and Insectary (SRF) Manager
- Fellow and advisor of Clinical Medicine at Kellogg College, University of Oxford
Dr Ahmed M Salman is a research group leader, and Senior Immunologist-Vaccinologist and working in Professor Sir Adrian Hill’s Lab at the Jenner Institute, at the University of Oxford – in partnership with Pirbright Institute – for developing innovative vaccines against cancerous, or infectious diseases, caused by human and veterinary pathogens. Dr Salman’s work aims mainly to identify, design and assess new target antigens as vaccine candidates for infectious diseases caused by human and veterinary pathogens (including Malaria, COVID-19, T Solium, and others) or cancerous diseases, using the most advanced technologies in immunology, vaccinology, molecular biology, biochemistry, proteomics, bioinformatics, genome editing, protein expression, and vaccine manufacturing. The promising vaccine candidates are assessed as target antigens and expressed in the most suitable vaccine platform including: viral vector vaccines to mainly induce cellular immune response; viral like particle (VLP) to induce a massive humoral immune response; or other platforms ( https://www.jenner.ac.uk/team/ahmed-salman)
Dr Salman took his BSc degree in Biochemistry at Ain Shams University in Cairo, Egypt in 2006 and from then until late 2011 was an instructor at the Department of Biochemistry, Faculty of Science, Ain Shams University. In parallel, he completed a successful Master’s degree on tuberculosis immunology and immune-diagnosis in 2011 from the Biochemistry department at Ain Shams University in Egypt, in collaboration with SSI, Copenhagen University in Denmark. Most of that laboratory work was done while he worked at Statens Serum Institut in Copenhagen, Denmark, which is a major centre for mycobacterial vaccine research. In 2011 Dr Salman won a PhD scholarship at the European Virtual Malaria Institute programme “EVIMalaR” funded by the European Commission and EMBL at Heidelberg, Germany. In 2012 Dr Salman started his DPhil (PhD) in clinical medicine at the University of Oxford in Professor Sir Adrian Hill’s Lab in Jenner Institute, in collaboration with Professor Chris Janse and Professor Shahid Khan, at the Leiden University Medical Centre in The Netherlands, aiming for the identification and assessment of novel human malaria vaccines. Dr Salman produced his DPhil thesis in October 2014 and the DPhil degree in Clinical Medicine was awarded to him in May 2015 from the University of Oxford ( https://ora.ox.ac.uk/objects/uuid%3A8c0e9338-3f33-4c83-b673-c17906ca1e38).
Dr Salman is a Co-PI and Senior Immunologist/Vaccinologist in different scientific research projects for vaccines development and clinical trials funded by national and international research funders, including Bill & Melinda Gates Foundation, European Commission, and Medical Research Council (MRC). The most important recent impact of his work has been on antigen down-selection for vaccine clinical trials. Dr Salman is a member of many international scientific communities, including the British Society for Immunology (BSI), the American Society of Tropical Medicine and Hygiene (ASTMH), and the International Veterinary Vaccinology Network (IVVN). Dr Salman is named as an inventor on three different Plasmodium falciparum Malaria vaccine patents that have been funded either for GMP manufacturing and clinical trials (https://patents.google.com/patent/WO2015052543A3/en).
In addition to the P. falciparum malaria vaccines, Dr Salman has a major contribution on another promising novel P. vivax malaria sporozoite vaccine that is about to move to GMP manufacture and clinical trials. Since April 2020 Dr Ahmed Salman became a part of the broad Jenner Institute research group, working on Oxford/AZ ChAdOx1 nCov-19 coronavirus vaccine. Oxford-AstraZeneca vaccine was a game-changer in the fight against the COVID-19 pandemic and the most widely distributed vaccine globally against SAR-CoV-2 virus with over two billion doses of the vaccine have been released, to more than 170 countries.
Recent publications
-
Vaccine-induced responses to R21/Matrix-M - an analysis of samples from a phase 1b age de-escalation, dose-escalation trial.
Journal article
Bundi C. et al, (2025), Frontiers in immunology, 16
-
Single-cell transcriptomic analysis of retinal immune regulation and blood-retinal barrier function during experimental autoimmune uveitis
Journal article
Quinn J. et al, (2024), Scientific Reports, 14
-
Rescue of cone and rod photoreceptor function in a CDHR1-model of age-related retinal degeneration
Journal article
Yusuf IH. et al, (2024), Molecular Therapy, 32, 1445 - 1460
-
Integrating Artificial Intelligence in Cybersecurity Education: A Pedagogical Framework and Case Studies
Conference paper
Salman A., (2024), 2024 International Conference on Computer and Applications Icca 2024
-
Position Paper: Leveraging Large Language Models for Cybersecurity Compliance
Conference paper
Salman A. et al, (2024), Proceedings - 9th IEEE European Symposium on Security and Privacy Workshops, Euro S and PW 2024, 496 - 503
-
Emulsion and liposome-based adjuvanted R21 vaccine formulations mediate protection against malaria through distinct immune mechanisms
Journal article
Reinke S. et al, (2023), Cell Reports Medicine, 4, 101245 - 101245
-
Injectable core-shell microspheres deliver prime-boost immunisation in a single shot
Preprint
Guyon R. et al, (2023)
-
Developmental Expression of the Cell Cycle Regulator p16INK4a in Retinal Glial Cells: A Novel Marker for Immature Ocular Astrocytes?
Journal article
Martinez-Fernandez de la Camara C. et al, (2023), Journal of Histochemistry & Cytochemistry, 71, 301 - 320
-
Minicircle Delivery to the Neural Retina as a Gene Therapy Approach.
Journal article
Staurenghi F. et al, (2022), International journal of molecular sciences, 23
-
Non-Viral Delivery of CRISPR/Cas Cargo to the Retina Using Nanoparticles: Current Possibilities, Challenges, and Limitations.
Journal article
Salman A. et al, (2022), Pharmaceutics, 14
-
Virus-like particle vaccines
Chapter
Mukhopadhyay E. et al, (2022), Vaccinology and Methods in Vaccine Research, 163 - 176
-
A universal vaccine candidate against Plasmodium vivax malaria confers protective immunity against the three PvCSP alleles.
Journal article
Gimenez AM. et al, (2021), Scientific reports, 11
-
Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina
Journal article
Salman A. et al, (2021), Cells, 10, 1957 - 1957
-
Screening of viral-vectored P. falciparum pre-erythrocytic candidate vaccine antigens using chimeric rodent parasites
Journal article
Kolli SK. et al, (2021), PLOS ONE, 16, e0254498 - e0254498
-
Dissection-independent production of Plasmodium sporozoites from whole mosquitoes
Journal article
Blight J. et al, (2021), Life Science Alliance, 4, e202101094 - e202101094
-
Ultra-low dose immunization and multi-component vaccination strategies enhance protection against malaria in mice.
Journal article
Collins KA. et al, (2021), Scientific reports, 11
-
Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 variant of concern 202012/01 (B.1.1.7): an exploratory analysis of a randomised controlled trial
Journal article
Emary KRW. et al, (2021), The Lancet, 397, 1351 - 1362
-
Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials
Journal article
Voysey M. et al, (2021), The Lancet, 397, 881 - 891
-
COVID-19 vaccines: Global challenges and prospects forum recommendations.
Journal article
Boudjelal M. et al, (2021), International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 105, 448 - 451
-
Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
Journal article
Voysey M. et al, (2021), The Lancet, 397, 99 - 111
-
Discovery of four new B-cell protective epitopes for malaria using Q beta virus-like particle as platform.
Journal article
Atcheson E. et al, (2020), NPJ vaccines, 5
-
Dissection-independent production of a protective whole-sporozoite malaria vaccine
Preprint
Blight J. et al, (2020)
-
Discovery of four new B-cell protective epitopes for malaria using Q beta virus-like particle as platform.
Journal article
Atcheson E. et al, (2020), NPJ vaccines, 5
-
Generation of a Genetically Modified Chimeric Plasmodium falciparum Parasite Expressing Plasmodium vivax Circumsporozoite Protein for Malaria Vaccine Development.
Journal article
Miyazaki Y. et al, (2020), Frontiers in cellular and infection microbiology, 10
-
Generation of Novel Plasmodium falciparum NF135 and NF54 Lines Expressing Fluorescent Reporter Proteins Under the Control of Strong and Constitutive Promoters.
Journal article
Miyazaki S. et al, (2020), Frontiers in cellular and infection microbiology, 10
-
Preclinical Development and Assessment of Viral Vectors Expressing a Fusion Antigen of Plasmodium falciparum LSA1 and LSAP2 for Efficacy against Liver-Stage Malaria
Journal article
Halbroth BR. et al, (2019), Infection and Immunity, 88
-
A P. falciparum NF54 Reporter Line Expressing mCherry-Luciferase in Gametocytes, Sporozoites, and Liver-Stages.
Journal article
Marin-Mogollon C. et al, (2019), Frontiers in cellular and infection microbiology, 9
-
Combination of RTS,S and Pfs25-IMX313 Induces a Functional Antibody Response Against Malaria Infection and Transmission in Mice
Journal article
Brod F. et al, (2018), Frontiers in Immunology, 9
-
A Plasmodium berghei sporozoite-based vaccination platform against human malaria
Journal article
Mendes AM. et al, (2018), npj Vaccines, 3
-
Adenovirus-prime and baculovirus-boost heterologous immunization achieves sterile protection against malaria sporozoite challenge in a murine model
Journal article
Yoshida K. et al, (2018), Scientific Reports, 8
-
Chimeric Plasmodium falciparum parasites expressing Plasmodium vivax circumsporozoite protein fail to produce salivary gland sporozoites
Journal article
Marin-Mogollon C. et al, (2018), Malaria Journal, 17
-
DOPS Adjuvant Confers Enhanced Protection against Malaria for VLP-TRAP Based Vaccines
Journal article
Cabral-Miranda G. et al, (2018), Diseases, 6, 107 - 107
-
Prime and target immunization protects against liver-stage malaria in mice
Journal article
Gola A. et al, (2018), Science Translational Medicine, 10, eaap9128 - eaap9128
-
Mutation in the intracellular chloride channel CLCC1 associated with autosomal recessive retinitis pigmentosa
Journal article
Li L. et al, (2018), PLoS Genetics, 14
-
OX40 Stimulation Enhances Protective Immune Responses Induced After Vaccination With Attenuated Malaria Parasites
Journal article
Othman AS. et al, (2018), Frontiers in Cellular and Infection Microbiology, 8
-
Tailoring aPlasmodium vivaxVaccine To Enhance Efficacy through a Combination of a CSP Virus-Like Particle and TRAP Viral Vectors
Journal article
Atcheson E. et al, (2018), Infection and Immunity, 86
-
An in vitro assay to measure antibody-mediated inhibition of P. berghei sporozoite invasion against P. falciparum antigens
Journal article
Rodríguez-Galán A. et al, (2017), Scientific Reports, 7
-
Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies
Journal article
Triller G. et al, (2017), Immunity, 47, 1197 - 1209.e10
-
Microcrystalline Tyrosine (MCT®): A Depot Adjuvant in Licensed Allergy Immunotherapy Offers New Opportunities in Malaria
Journal article
Cabral-Miranda G. et al, (2017), Vaccines, 5, 32 - 32
-
The use of transgenic parasites in malaria vaccine research
Journal article
Othman AS. et al, (2017), Expert Review of Vaccines, 16, 685 - 697
-
Rational development of a protective P. vivax vaccine evaluated with transgenic rodent parasite challenge models
Journal article
Salman AM. et al, (2017), Scientific Reports, 7
-
Introducing the ESAT-6 free IGRA, a companion diagnostic for TB vaccines based on ESAT-6
Journal article
Ruhwald M. et al, (2017), Scientific Reports, 7
-
Evaluation of Plasmodium vivax Cell-Traversal Protein for Ookinetes and Sporozoites as a Preerythrocytic P. vivax Vaccine
Journal article
Alves E. et al, (2017), Clinical and Vaccine Immunology, 24
-
Assessment of the Plasmodium falciparum Preerythrocytic Antigen UIS3 as a Potential Candidate for a Malaria Vaccine
Journal article
Longley RJ. et al, (2017), Infection and Immunity, 85
-
The Plasmodium falciparum Cell-Traversal Protein for Ookinetes and Sporozoites as a Candidate for Preerythrocytic and Transmission-Blocking Vaccines
Journal article
Espinosa DA. et al, (2017), Infection and Immunity, 85
-
Enhancing cellular immunogenicity of MVA-vectored vaccines by utilizing the F11L endogenous promoter
Journal article
Alharbi NK. et al, (2016), Vaccine, 34, 49 - 55
-
Comparative assessment of vaccine vectors encoding ten malaria antigens identifies two protective liver-stage candidates
Journal article
Longley RJ. et al, (2015), Scientific Reports, 5
-
Progress with viral vectored malaria vaccines: A multi-stage approach involving “unnatural immunity”
Journal article
Ewer KJ. et al, (2015), Vaccine, 33, 7444 - 7451
-
Is this actually CIN?
Journal article
Self JE. et al, (2015), Pediatric Neurology, 53
-
Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition
Journal article
Hopp CS. et al, (2015), eLife, 4
-
Generation of Transgenic Rodent Malaria Parasites Expressing Human Malaria Parasite Proteins
Journal article
Salman AM. et al, (2015), 257 - 286
-
Human B cells produce chemokine CXCL10 in the presence of Mycobacterium tuberculosis specific T cells
Journal article
Hoff ST. et al, (2015), Tuberculosis, 95, 40 - 47
-
Development of an in vitro Plasmodium parasite killing assay for the evaluation of cell-mediated immune responses following vaccination with pre-erythrocytic malaria vaccine candidates
Journal article
Bliss CM. et al, (2014), Malaria Journal, 13
-
Development of novel vaccine candidates and challenge models for Plasmodium vivax
Journal article
Alves E. et al, (2014), Malaria Journal, 13
-
Assessment of T cell response to novel Mycobacterium tuberculosis synthetic overlapping peptides mixtures (Rv2659 and Rv2660) and ESAT-6 in Egyptian patients.
Journal article
Salman AM. et al, (2014), The Egyptian journal of immunology, 21, 75 - 83
-
The possibility of using the blending of plants waste (Bagasse) in some textile end use
Journal article
Salman A. et al, (2013), Life Science Journal, 10, 2075 - 2086
-
Evaluation of immunodiagnostic potential of ESAT-6 synthetic peptides mixture in Egyptian pulmonary tuberculosis patients.
Journal article
Salman AM. et al, (2012), The Egyptian journal of immunology, 19, 19 - 30