Professor Dame Sarah Gilbert
IMS-Tetsuya Nakamura Building, Old Road Campus, Roosevelt Dr, Headington, Oxford, OX3 7TY
Said Professorship of Vaccinology (DBE)
- Dame Commander of the Most Excellent Order of the British Empire (DBE), for services to Science and Public Health
Professor Gilbert joined the Nuffield Department of Medicine at Oxford University in 1994 and became part of the Jenner Institute (within NDM) when it was founded in 2005. Her chief research interest is the development of viral vectored vaccines that work by inducing strong and protective T and B cell responses. She leads work on influenza vaccine development as well as vaccines for many different emerging pathogens, including Nipah virus, MERS, and Lassa virus.
Professor Gilbert’s work also focuses on the rapid transfer of vaccines into GMP manufacturing and first in human trials. This is achieved through collaboration with colleagues in the Clinical Biomanufacturing Facility and Centre for Clinical Vaccinology and Tropical Medicine, all situated on the Old Road Campus in Oxford.
In 2020 Professor Gilbert became the Oxford Project Leader for ChAdOx1 nCoV-19, a vaccine against the novel coronavirus SARS-CoV-2. This vaccine, tested by the University of Oxford in clinical trials of over 23,000 people in the UK, Brazil and South Africa, is now in use in many countries around the world in the fight against the Covid-19 Pandemic.
‘I have worked in the development of vaccines against infectious pathogens for many years and in the last 2 years have been able to draw on all that I have learned in order to respond to the SARS-CoV-2 pandemic. I have been so fortunate to work with a very talented and dedicated team who made it possible to develop a vaccine in less time than anyone thought possible.’
ChAdOx1 COVID vaccines express RBD open prefusion SARS-CoV-2 spikes on the cell surface.
Ni T. et al, (2023), iScience, 26
Infection- or AZD1222 vaccine-mediated immunity reduces SARS-CoV-2 transmission but increases Omicron competitiveness in hamsters.
Port JR. et al, (2023), Nature communications, 14
Safety and immunogenicity of a ChAdOx1 vaccine against Rift Valley fever in UK adults: an open-label, non-randomised, first-in-human phase 1 clinical trial
Jenkin D. et al, (2023), The Lancet Infectious Diseases, 23, 956 - 964
ChAdOx1 nCoV-19 (AZD1222) vaccine-induced Fc receptor binding tracks with differential susceptibility to COVID-19.
Kaplonek P. et al, (2023), Nature immunology
COVID-19 vaccines and the pandemic: lessons learnt for other neglected diseases and future threats.
Hotez PJ. et al, (2023), BMJ global health, 8
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