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Cytotoxic T-lymphocyte (CTL) and T-helper-cell responses in various mouse strains were monitored. Protective CTL responsiveness against three proteins of vesicular stomatitis virus was H-2 linked and inducible only in half of the 15 combinations tested (each of five H-2 haplotypes combined with each of three viral proteins), whereas biologically relevant T-helper-cell responses were inducible in all. This suggests that vesicular stomatitis virus exhibits more T-helper-cell than CTL epitopes.

Type

Journal article

Journal

Journal of virology

Publication Date

06/1993

Volume

67

Pages

3680 - 3683

Addresses

Institute of Experimental Immunology, University of Zürich, Switzerland.

Keywords

B-Lymphocytes, T-Lymphocyte Subsets, T-Lymphocytes, T-Lymphocytes, Helper-Inducer, T-Lymphocytes, Cytotoxic, Animals, Mice, Inbred Strains, Mice, Capsid, Virus Diseases, Membrane Glycoproteins, Antigens, CD4, Viral Core Proteins, Viral Envelope Proteins, Antigens, CD8, Antibodies, Viral, H-2 Antigens, Antigens, Viral, Epitopes, Vesicular stomatitis Indiana virus