HLA correlates in a cohort of slow progressors from China: Effects on HIV-1 disease progression
Rai MA., Zhang Y., Yindom LM., Holmes J., Yu LM., Hao C., Rostron T., Yan H., Zhang YL., Cai C., McMichael AJ., Dong T., Rowland-Jones SL., Blais ME., Xu KY.
We looked at our HIVRslow progressors cohort to determine if there were any human leukocyte antigen (HLA) correlates for protection. No statistically significant allelic differences were found between the HIVRand control cohorts using regression analysis, though trendswere noted. Data for Elite Controllers showed an increased frequency of BM57. Likewise, no correlation was inferred with the clinical data of the HIVRcohort. We hypothesize that the protective effect of HLA alleles may have been lost over time. © 2013 Wolters Kluwer Health | Lippincott Williams & Wilkins.