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We describe the characterization of a novel HLA Class I molecule, which we have isolated from chorionic cytotrophoblast cell membranes, and from a trophoblast-derived choriocarcinoma cell line, BeWo; classical HLA Class I antigens are not expressed on these cells. This antigen is an electrophoretically non-polymorphic glycoprotein of approximately 40,000 molecular weight, which is found in association with beta 2 microglobulin, and which is detected by monoclonal antibodies recognizing monomorphic determinants of HLA Class I. Elucidation of the nature and origin of this molecule may provide valuable information regarding the immune barrier that exists between mother and fetus.

Type

Journal article

Journal

Immunology

Publication Date

12/1986

Volume

59

Pages

595 - 601

Keywords

Cell Line, Trophoblasts, Humans, Choriocarcinoma, Uterine Neoplasms, Antigens, Neoplasm, HLA Antigens, Electrophoresis, Polyacrylamide Gel, Isoelectric Focusing, Pregnancy, Molecular Weight, Female