Early and nonreversible decrease of CD161++/MAIT cells in HIV infection
Cosgrove C., Ussher JE., Rauch A., Gärtner K., Kurioka A., Hühn MH., Adelmann K., Kang Y-H., Fergusson JR., Simmonds P., Goulder P., Hansen TH., Fox J., Günthard HF., Khanna N., Powrie F., Steel A., Gazzard B., Phillips RE., Frater J., Uhlig H., Klenerman P.
<jats:title>Key Points</jats:title><jats:p>The frequency of CD161++ MAIT cells is dramatically decreased in the blood of HIV-infected patients, and they are nonrecoverable with HAART. Gut sequestration and apoptosis in response to bacterial signals may, amongst others, be mechanisms that contribute to this.</jats:p>