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Extravillous trophoblast from normal human placenta has been shown previously to express an unusual form of HLA class I molecule, as does a choriocarcinoma cell line, BeWo. This molecule has a H chain of approximately 40 kDa and appears to be nonpolymorphic. We have isolated and sequenced a HLA class I cDNA clone, which probably corresponds to this molecule, from a library derived from BeWo. The nucleotide sequence shows a high degree of homology with the published sequence of a genomic clone, HLA 6.0, which is the product of a class I locus other than A, B, or C, (provisionally designated "HLA G"). The expressed product of this locus has not previously been localized. We have used the polymerase chain reaction to demonstrate the presence of similar HLA class I sequences in cDNA from normal extravillous trophoblast. Although there is some nucleotide sequence polymorphism the amino acid sequence of this molecule is conserved. It is therefore unlikely to provoke immune responses even though it is found at the fetal-maternal interface.


Journal article


Journal of immunology (Baltimore, Md. : 1950)

Publication Date





731 - 735


Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK.


Tumor Cells, Cultured, Trophoblasts, Humans, Choriocarcinoma, RNA, Messenger, Histocompatibility Antigens Class I, Cloning, Molecular, Polymerase Chain Reaction, Amino Acid Sequence, Base Sequence, Molecular Sequence Data