Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

There is now a very good understanding of the way in which epitope peptides are generated from virus proteins and how the peptides bind to the class I MHC molecules. This gives a framework in which to analyse the potentially protective cytotoxic T lymphocyte response in human immunodeficiency virus infection. A detailed understanding of the specificity of the responding T cells, the clonality of these T cells and the effects of virus variation on the CTL gives a possible explanation for the ultimate failure of the CTL response to control this virus infection.

Type

Conference paper

Publication Date

01/1995

Volume

22

Pages

51 - 62

Addresses

Institute of Molecular Medicine, John Radcliffe Hospital, Oxford.

Keywords

T-Lymphocytes, Cytotoxic, Humans, Acquired Immunodeficiency Syndrome, Peptides, Histocompatibility Antigens Class I, Antigens, Viral, Epitopes