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Immune tolerance to self-glycans is a host mechanism to avoid autoimmunity, which is exploited by HIV-1 coating its envelope glycoproteins with glycans to evade neutralising antibodies (nAbs). Huettner et al. describe cross-reactivity between Schistosoma mansoni glycans and HIV-1 envelope glycoprotein glycans, suggesting a strategy for induction of HIV-1 nAbs by vaccination.

Original publication




Journal article


Trends in parasitology

Publication Date



The Sir William Dunn School of Pathology, University of Oxford, Oxford, OX1 3RE, UK.