Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Although gammadelta cells are commonly hypothesized to provide a 'first line of defence', gammadelta-cell-deficient mice are generally only marginally more susceptible to pathogens. Because gammadelta cells are enriched within epithelia, it is important to resolve whether immunoprotective capacity towards epithelial-tropic pathogens is absent from the gammadelta-cell compartment, or whether such activity is present but simply redundant with that of alphabeta T cells. In this work, following infection of the intestinal epithelium of alphabeta T-cell-deficient mice with the coccidian parasite, Eimeria vermiformis, gammadelta cells were shown to support the rapid activation of other lymphoid cells and to confer a transferable antipathogen effect that could be eradicated by neutralization of interferon-gamma. However, unlike alphabeta T cells, these effects of gammadelta cells showed no evidence of functional immunological memory. These results are directly relevant to coccidiosis, an economically significant disease of livestock, and should have general relevance to infections involving alphabeta T-cell deficiencies, e.g. cryptosporidiosis in patients with acquired immune deficiency syndrome (AIDS).

Original publication

DOI

10.1046/j.1365-2567.2000.00122.x

Type

Journal article

Journal

Immunology

Publication Date

11/2000

Volume

101

Pages

325 - 332

Addresses

Institute of Animal Health, Compton, Berkshire, and Peter Gorer Department of Immunobiology, Guy's King's St Thomas' Medical School, Guy's Hospital, London, UK.

Keywords

Mesentery, Lymph Nodes, T-Lymphocyte Subsets, Animals, Mice, Inbred C57BL, Mice, Eimeria, Coccidiosis, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta, Adoptive Transfer, Immunity, Cellular, Immunologic Memory, Interferon-gamma