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Just published - the report covers a summary of progress across the Institute's portfolio of research programmes and update on latest activities. The Institute has expanded substantially in the last 10 years with several enlarging groups, strategic recruitments and a broadening base of funders from four continents. Recently, the Institute’s capacity to undertake small scale first-in-human trials very rapidly was illustrated by the request from the World Health Organization to undertake, with collaborators, the first trial of a new Ebola vaccine destined for West Africa in the 2014 outbreak.