Optimizing parallel induction of HIV type 1-specific antibody and T-cell responses by multicomponent subunit vaccines
Clutton G., Carpov A., Parks CL., Dean HJ., Montefiori DC., Hanke T.
© 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins. Objectives: Protection against HIV type 1 (HIV-1) infection/AIDS will likely require concerted actions of protective CD8+ killer T cells and protective antibodies. The challenges in inducing such effectors by active immunization are such that the T-cell and antibody vaccine components require separate development. Here, a rational attempt is taken to combine two separately optimized heterologous regimens into a single T-cell-inducing and antibody-inducing vaccination schedule with minimal induction of unprotective Env-specific T cells.