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Recent genome-wide studies have reported novel associations between common polymorphisms and susceptibility to many major infectious diseases in humans. In parallel, an increasing number of rare mutations underlying susceptibility to specific phenotypes of infectious disease have been described. Together, these developments have highlighted a key role for host genetic variation in determining the susceptibility to infectious disease. They have also provided insights into the genetic architecture of infectious disease susceptibility and identified immune molecules and pathways that are directly relevant to the human host defence. © 2012 Macmillan Publishers Limited. All rights reserved.

Original publication

DOI

10.1038/nrg3114

Type

Journal article

Journal

Nature Reviews Genetics

Publication Date

01/03/2012

Volume

13

Pages

175 - 188