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In vivo antigenic competition of naive CD4+ TCR transgenic T cells was visualized by tracking cell division. Competition reduced both recruitment into cell division and burst size per recruited precursor cell, minimizing the effect of differences in precursorfrequency while maintaining the dose-response relationship with antigen. Competition was restricted to T cells of the same specificity, indicating that cells were competing for access to Ag-MHC complexes rather than for Ag nonspecific factors. Moreover, the qualitative distinction between the responses to i.v. peptide and s.c. peptide/CFA was unaffected by precursor frequency. These data explain the paradoxical ability of the immune system to tailor responses to the type and dose of Ag even in individuals with large differences in initial precursor frequency.

Original publication

DOI

10.1016/s1074-7613(00)00076-5

Type

Journal article

Journal

Immunity

Publication Date

12/2000

Volume

13

Pages

783 - 794

Addresses

Centenary Institute of Cancer Medicine and Cell Biology, Newtown, Australia.

Keywords

CD4-Positive T-Lymphocytes, Hematopoietic Stem Cells, Animals, Mice, Inbred C57BL, Mice, Transgenic, Mice, Peptides, Injections, Intravenous, Injections, Subcutaneous, Cell Division, Major Histocompatibility Complex, Kinetics