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Vertebrate immune systems contain T cells bearing either alpha beta or gamma delta T-cell antigen receptors (TCRs). alpha beta T cells perform all well-characterized T-cell effector functions, while the biological functions of gamma delta + cells remain unclear. Of particular interest is the role of gamma delta + cells during epithelial infections, since gamma delta + cells are commonly abundant within epithelia. Eimeria spp. are intracellular protozoa that infect epithelia of most vertebrates, causing coccidiosis. This study shows that in response to Eimeria vermiformis, mice lacking alpha beta T cells display defects in protective immunity, while mice lacking gamma delta + cells display exaggerated intestinal damage, apparently due to a failure to regulate the consequences of the alpha beta T cell response. An immuno-downregulatory role during infection, and during autoimmune disease, may be a general one for gamma delta + cells.

Original publication

DOI

10.1073/pnas.93.21.11774

Type

Journal article

Journal

Proceedings of the National Academy of Sciences of the United States of America

Publication Date

10/1996

Volume

93

Pages

11774 - 11779

Addresses

Department of Biology, Yale University, New Haven, CT 06520, USA.

Keywords

Intestinal Mucosa, Intestine, Small, Lymph Nodes, T-Lymphocytes, CD4-Positive T-Lymphocytes, Animals, Mice, Inbred Strains, Mice, Inbred C57BL, Mice, Knockout, Mice, Eimeria, Coccidiosis, Intestinal Diseases, Gastrointestinal Hemorrhage, Receptors, Antigen, T-Cell, alpha-beta, Receptors, Antigen, T-Cell, gamma-delta, Lymphocyte Transfusion, Adoptive Transfer, Phenotype