Contact information
Paola Cicconi
Principal investigator
- Senior Clinical Researcher
- Clinical Director of the Jenner Service Research Facility
Supported by a dedicate clinical research team, I provide leadership in vaccine development at the University of Oxford, establishing equitable partnerships with senior immunologists to advance vaccine candidates from bench to clinic.
I oversee the clinical development of the Oxford HIV vaccine programme, delivering Phase I/IIa trials of HIVconsvX vaccines in the UK and internationally, while my dual role as Clinical Lead for the HIV Service at Oxford University Hospital has enabled me to expand research into innovative strategies towards HIV cure. This integration of clinical care and academic research has built local capacity and created meaningful opportunities for people living with HIV to participate in research.
Beyond HIV, we play a leading role in global health vaccine programmes, including the clinical development of malaria transmission-blocking vaccines in collaboration with partners across Africa. These international trials target adolescents and children in endemic regions, while my contribution to the malaria liver-stage programme focuses on women of childbearing potential.
I have strengthened innovation pipelines by forging collaborations with biotech partners, leading commercial trials on priority pathogens through the Jenner Clinical Trial Unit, and contributing my expertise to the design of the new Service Research Facility at the Jenner Institute. I aim to continue to drive forward vaccine clinical development and HIV research by fostering national and international collaborations that translate innovation into impact.
Recent publications
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Lenacapavir: Patient and healthcare provider perceptions and the potential role for a twice-yearly injectable HIV treatment.
Journal article
Alford K. et al, (2024), HIV Med
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HBV001: Phase I study evaluating the safety and immunogenicity of the therapeutic vaccine ChAdOx1-HBV.
Journal article
Cargill T. et al, (2023), JHEP reports : innovation in hepatology, 5
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Re-valuation of annual cytology using HPV self-sampling to upgrade prevention (REACH UP): A feasibility study in women living with HIV in the UK.
Journal article
Cicconi P. et al, (2022), HIV Med, 23, 390 - 396
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Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)
Journal article
Flaxman A. et al, (2021), The Lancet, 398, 981 - 990
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Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial
Journal article
Ramasamy MN. et al, (2020), The Lancet, 396, 1979 - 1993