Increased severity of respiratory infections associated with elevated anti-LPS IgG2 which inhibits serum bactericidal killing
Wells TJ., Whitters D., Sevastsyanovich YR., Heath JN., Pravin J., Goodall M., Browning DF., O’Shea MK., Cranston A., De Soyza A., Cunningham AF., MacLennan CA., Henderson IR., Stockley RA.
<jats:p>An antibody directed against the O-antigen of Pseudomonas aeruginosa LPS can block complement-mediated bacterial killing and contributes to the severity of respiratory infection.</jats:p>