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A preliminary study of gag-specific, MHC-restricted CD8+ CTL has been performed in nine Gambian patients infected with HIV2. Such CTL were present in at least 55% of patients in fresh peripheral blood mononuclear cells without the requirement for in vitro restimulation. We have identified a nonamer peptide from HIV2 gag that is recognized by CD8+ HLA-B53 CTL using an amino acid sequence motif predicted from analysis of endogenous peptides eluted from HLA-B53 molecules. This peptide, from an HIV2/SIV conserved sequence, has previously been reported to be recognized by CTL from non-human primates vaccinated with recombinant vaccinia virus expressing the gag protein of SIV or infected with SIV virus. HLA-B53-restricted, HIV2 gag-specific CTL did not recognize target cells expressing HIV1 gag proteins, indicating that no cellular cross protection to HIV1 could be expected in this case.

Type

Journal article

Journal

Journal of immunology (Baltimore, Md. : 1950)

Publication Date

09/1993

Volume

151

Pages

3361 - 3369

Addresses

Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK.

Keywords

T-Lymphocytes, Cytotoxic, Humans, HIV-2, HIV Infections, HIV Seropositivity, Peptides, Gene Products, gag, Recombinant Proteins, Epitopes, Cytotoxicity, Immunologic, Immunity, Cellular, Major Histocompatibility Complex, Amino Acid Sequence, Molecular Sequence Data, Gambia