Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Structural studies of foot-and-mouth disease virus (FMDV) have largely focused on the mature viral particle, providing atomic resolution images of the spherical protein capsid for a number of sero- and sub-types, structures of the highly immunogenic surface loop, Fab and GAG receptor complexes. Additionally, structures are available for a few non-structural proteins. The chapter reviews our current structural knowledge and its impact on our understanding of the virus life cycle proceeding from the mature virus through immune evasion/inactivation, cell-receptor binding and replication and alludes to future structural targets.

Original publication

DOI

10.1007/3-540-27109-0_4

Type

Journal article

Journal

Current topics in microbiology and immunology

Publication Date

01/2005

Volume

288

Pages

71 - 101

Addresses

Division of Structural Biology, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Oxford, OX3 7BN, UK.

Keywords

Foot-and-Mouth Disease Virus, Integrins, Receptors, Virus, Viral Nonstructural Proteins, Capsid Proteins, Virus Assembly, Genome, Viral, Heparan Sulfate Proteoglycans