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We present detailed studies of human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte (CTL) responses to clade A or C HIV type 1 in three donors infected in East Africa. We define several novel non-clade B CTL epitopes, including some restricted by HLA alleles common in Africans. Although cross-clade CTL recognition of these epitopes does occur, recognition can also be highly clade specific.

Type

Journal article

Journal

Journal of virology

Publication Date

02/1999

Volume

73

Pages

1708 - 1714

Addresses

Molecular Immunology Group, Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, United Kingdom.

Keywords

T-Lymphocytes, Cytotoxic, Cells, Cultured, Humans, HIV-1, HIV Infections, Epitopes, T-Lymphocyte, Amino Acid Sequence, Molecular Sequence Data, Africa, Eastern, Female, Male