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Development of a cytomegalovirus (CMV) vaccine is a high priority due to its significant global impact-contributing to mortality in immunosuppressed individuals, neurodevelopmental delay in infected neonates and non-genetic sensorineural hearing loss. The impact of CMV on the general population has been less well studied; however, a wide range of evidence indicates that CMV may increase the risk of atherosclerosis, cancer, immunosenescence, and progression of tuberculosis (TB) and human immunodeficiency virus. Due to the high seroprevalence of CMV worldwide, any modulation of risk by CMV is likely to have a significant impact on the epidemiology of these diseases. This review will evaluate how CMV may cause morbidity and mortality outside of the neonatal and immunosuppressed populations and consider the potential impact of a CMV vaccine on these outcomes.

Original publication

DOI

10.1002/rmv.2405

Type

Journal article

Journal

Reviews in medical virology

Publication Date

01/2023

Volume

33

Addresses

Department of Paediatrics, Horton General Hospital, Oxford University Hospitals, Banbury, UK.

Keywords

Humans, Cytomegalovirus Infections, Cytomegalovirus Vaccines, Seroepidemiologic Studies, Infant, Newborn, Vaccine Development