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<jats:title>Abstract</jats:title><jats:p>Clinical development of the COVID-19 vaccine candidate ChAdOx1 nCoV-19, a replication-deficient simian adenoviral vector expressing the full-length SARS-CoV-2 spike (S) protein was initiated in April 2020 following non-human primate studies using a single immunisation. Here, we compared the immunogenicity of one or two doses of ChAdOx1 nCoV-19 in both mice and pigs. Whilst a single dose induced antigen-specific antibody and T cells responses, a booster immunisation enhanced antibody responses, particularly in pigs, with a significant increase in SARS-CoV-2 neutralising titres.</jats:p>

Original publication

DOI

10.1101/2020.06.20.159715

Type

Journal article

Publisher

Cold Spring Harbor Laboratory

Publication Date

21/06/2020