Adipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases
Akoumianakis I., Sanna F., Margaritis M., Badi I., Akawi N., Herdman L., Coutinho P., Fagan H., Antonopoulos AS., Oikonomou EK., Thomas S., Chiu AP., Chuaiphichai S., Kotanidis CP., Christodoulides C., Petrou M., Krasopoulos G., Sayeed R., Lv L., Hale A., Naeimi Kararoudi M., McNeill E., Douglas G., George S., Tousoulis D., Channon KM., Antoniades C.
Adipose-secreted WNT5A triggers vascular disease in obesity, activating vascular smooth muscle cell migration by an NADPH oxidase–dependent mechanism.