Fibroblasts as Efficient Antigen-Presenting Cells in Lymphoid Organs
Kündig TM., Bachmann MF., DiPaolo C., Simard JJL., Battegay M., Lother H., Gessner A., Kühlcke K., Ohashi PS., Hengartner H., Zinkernagel RM.
Only so-called "professional" antigen-presenting cells (APCs) of hematopoietic origin are believed capable of inducing T lymphocyte responses. However, fibroblasts transfected with viral proteins directly induced antiviral cytotoxic T lymphocyte responses in vivo, without involvement of host APCs. Fibroblasts induced T cells only in the milieu of lymphoid organs. Thus, antigen localization affects self-nonself discrimination and cell-based vaccine strategies.