Tom is a physician training in Infectious Diseases & Microbiology and a Wellcome Trust Research Training Fellow at The Jenner Institute. His DPhil research, as part of the blood-stage malaria team, is focused on developing an effective vaccine against Plasmodium vivax malaria. This species of malaria, despite being the most globally widespread of the human malarias and responsible for a huge morbidity burden, has been historically overlooked by researchers.
One approach in Tom's project is to isolate a panel of human monoclonal antibodies (mAbs) against the leading blood-stage vivax vaccine antigen, from volunteers in the recent vivax vaccine trial. Through structural studies on the most potent and broadly neutralising of these mAbs in complex with the antigen he hopes to define critical binding sites and enable structure-guided immunogen design.
Isolation of human monoclonal antibodies from vaccinated individuals with a view to therapeutic application
Elias S. et al, (2015), HUMAN GENE THERAPY, 26, A23 - A23
From Haiti to the Amazon: Public Health Issues Related to the Recent Immigration of Haitians to Brazil
Rawlinson T. et al, (2014), PLoS Neglected Tropical Diseases, 8, e2685 - e2685