Sarah Silk
Clinical Trials Immunologist
Research
I work on the Clinical Trials conducted as part of the Blood-Stage Malaria Programme led by Professor Simon Draper.
This programme includes both Phase I safety and immunogenicity studies and Phase II controlled human malaria infection studies. My role focuses on the characterisation of human humoral and cellular immune responses to the candidate vaccines and malaria exposure against both Plasmodium falciparum and Plasmodium vivax.
Additionally, I work closely with collaborating field sites in Africa, to conduct Clinical Trials in a malaria-endemic setting.
Recent publications
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A defined mechanistic correlate of protection against Plasmodium falciparum malaria in non-human primates
Journal article
Douglas AD. et al, (2019), Nature Communications, 10
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Harmonization study between three laboratories for expression of malaria vaccine clinical trial IgG antibody ELISA data in µg/mL
Journal article
Labbé GM. et al, (2019), Malaria Journal, 18
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Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralizing vaccine-induced human antibody
Journal article
Rawlinson TA. et al, (2019), Nature Microbiology, 4, 1497 - 1507
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Functional Comparison of Blood-Stage Plasmodium falciparum Malaria Vaccine Candidate Antigens
Journal article
Illingworth JJ. et al, (2019), Frontiers in Immunology, 10
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Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies
Journal article
Alanine DGW. et al, (2019), Cell, 178, 216 - 228.e21