Rebecca Powell Doherty
Dissecting the biological basis of HLA variation to susceptibility, disease progression, and response to therapies in Crohn’s Disease and Ulcerative Colitis
My work focuses on the development and progression of disease in individuals who have moderate to severe Crohn's Disease or Ulcerative Colitis. I investigate those with a known very strong but so far unexplained genetic predisposition to either severe colitis, or to developing antibodies which neutralise drugs known as anti-TNF biologics used in the treatment of inflammatory bowel disease in order to study the immunological mechanisms that underlie this genetic predisposition.
The genes involved are referred to as the HLA system, which are involved in regulating the immune response - these genes encode proteins that interact with antigens or fragments of antigens. In one aspect of this work, we hope to be able to identify the specific antigens in the environment that trigger severe colitis, informing pathogenesis of disease. In another aspect, we hope to identify the parts of the drugs which are responsible for causing patients to developing neutralising antibodies to biologics. This may allow a rational drug design of a non-immunogenic molecule.
Effect of Systemic Triphenylphosphonium on Organ Function and Oxidative Stress.
Powell RD. et al, (2018), The American surgeon, 84, 36 - 42
Examining the role of follow-up skeletal surveys in non-accidental trauma
Powell-Doherty RD. et al, (2017), The American Journal of Surgery, 213, 606 - 610
A survey of quality of life indicators in the Romanian Roma population following the 'Decade of Roma Inclusion'.
Powell Doherty R. et al, (2017), F1000Research, 6
Cytochrome c limits oxidative stress and decreases acidosis in a rat model of hemorrhagic shock and reperfusion injury
Powell RD. et al, (2017), Journal of Trauma and Acute Care Surgery, 82, 35 - 41
EXOGENOUS CYTOCHROME C IMPROVES ACIDOSIS AND OXIDATIVE STRESS IN A RAT MODEL OF HEMORRHAGIC SHOCK
Powell R. et al, (2015), CRITICAL CARE MEDICINE, 43