dipose tissue–derived WNT5A regulates vascular redox signaling in obesity via USP17/RAC1-mediated activation of NADPH oxidases

Akoumianakis I., Sanna F., Margaritis M., Badi I., Akawi N., Herdman L., Coutinho P., Fagan H., Antonopoulos AS., Oikonomou EK., Thomas S., Chiu AP., Chuaiphichai S., Kotanidis CP., Christodoulides C., Petrou M., Krasopoulos G., Sayeed R., Lv L., Hale A., Naeimi Kararoudi M., McNeill E., Douglas G., George S., Tousoulis D., Channon KM., Antoniades C.

Adipose-secreted WNT5A triggers vascular disease in obesity, activating vascular smooth muscle cell migration by an NADPH oxidase–dependent mechanism.

DOI

10.1126/scitranslmed.aav5055

Type

Journal article

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

2019-09-18T00:00:00+00:00

Volume

11

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