Marion Watson
Contact information
Centre for Clinical Vaccinology and Tropical Medicine, University of Oxford, Churchill Hospital, Oxford OX3 7LE
Research groups
Marion Watson
Head of Operations, Clinical Trials
Dr Marion Watson is Head of Operations at the Jenner Institute overseeing a wide range of clinical trial research and development activities on vaccines for malaria, TB and emerging pathogens, notably since early 2020 vaccine trials for COVID-19.
Following a biochemistry degree and PhD in molecular biology at Imperial College, London she spent 15 years in early phase drug discovery in pharma before returning to academic research at Oxford 1997. Working from the NHS based Public Health Resource Unit she was a researcher on a range of public health and primary care studies, ran the Primary Healthcare Research Network and became a Senior Lecturer in research methods at Oxford Brookes University. She developed intensive undergraduate and Masters level modules at a time when GCP training was unavailable outside commercial settings and continues to work in training development and delivery through the NIHR and at Imperial College London.
At Oxford University she spent 3 years as a Senior Research Support Associate in the Clinical Trials and Research Governance team providing sponsorship reviews, GCP monitoring, support and training for researchers. Alongside she was Biological Safety Officer for the Oxford Radcliffe Hospitals NHS Trust from 2001 to 2011 with a remit for governance of all work involving Genetically Modified Organisms, notably Gene Therapy Clinical Trials including a range of vaccine trials at the Jenner Institute. In 2011 she moved to Imperial College London as Quality Assurance Manager for the Imperial Clinical Research Facility, an early phase clinical trials unit and part of the Imperial Centre for Translational and Experimental Medicine. She returned to Oxford in 2017 as Operational Lead for Experimental Medicine and Rheumatology in the Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences before moving to the Jenner Institute.
Key publications
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Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses
Journal article
Barrett JR. et al, (2021), Nature Medicine, 27, 279 - 288
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Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK
Journal article
Voysey M. et al, (2021), The Lancet, 397, 99 - 111
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Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial
Journal article
Ramasamy MN. et al, (2020), The Lancet, 396, 1979 - 1993
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Single-dose administration and the influence of the timing of the booster dose on immunogenicity and efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine: a pooled analysis of four randomised trials
Journal article
Voysey M. et al, (2021), The Lancet, 397, 881 - 891
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Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
Journal article
Folegatti PM. et al, (2020), The Lancet, 396, 467 - 478
Recent publications
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Development and validation of a prediction model for self-reported mobility decline in community-dwelling older adults
Journal article
Sanchez-Santos MT. et al, (2022), Journal of Clinical Epidemiology
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Reactogenicity and immunogenicity after a late second dose or a third dose of ChAdOx1 nCoV-19 in the UK: a substudy of two randomised controlled trials (COV001 and COV002)
Journal article
Flaxman A. et al, (2021), The Lancet, 398, 981 - 990
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Efficacy of ChAdOx1 nCoV-19 (AZD1222) vaccine against SARS-CoV-2 lineages circulating in Brazil; an exploratory analysis of a randomised controlled trial
Journal article
Clemens SC. et al, (2021)
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Hand Osteoarthritis: investigating Pain Effects of estrogen-containing therapy (HOPE-e): a protocol for a feasibility randomised placebo-controlled trial.
Journal article
Marian IR. et al, (2021), Pilot and feasibility studies, 7
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Author Correction: Phase 1/2 trial of SARS-CoV-2 vaccine ChAdOx1 nCoV-19 with a booster dose induces multifunctional antibody responses
Journal article
Barrett JR. et al, (2021), Nature Medicine, 27, 1113 - 1113