Carina Joe
Senior Research Scientist
Douglas Group
Process development for manufacturing viral-vector based vaccine.
My research investigates improved methods of manufacturing vaccines, including adenovirus vectors. I developed at small scale the manufacturing process which is being used to manufacture a billion doses of the Oxford-AZ COVID-19 vaccine.
Recent publications
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Rapid-response manufacturing of adenovirus-vectored vaccines
Journal article
Joe CCD. et al, (2023), Nature Biotechnology
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Immunogenicity of Wild Type and Mutant Hepatitis B Surface Antigen Virus-like Particles (VLPs) in Mice with Pre-Existing Immunity against the Wild Type Vector.
Journal article
Kingston NJ. et al, (2023), Viruses, 15
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Manufacturing a chimpanzee adenovirus-vectored SARS-CoV-2 vaccine to meet global needs.
Journal article
Joe CCD. et al, (2022), Biotechnology and bioengineering, 119, 48 - 58
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Safety and immunogenicity of ChAdOx1 nCoV-19 vaccine administered in a prime-boost regimen in young and old adults (COV002): a single-blind, randomised, controlled, phase 2/3 trial
Journal article
Ramasamy MN. et al, (2020), The Lancet, 396, 1979 - 1993