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<jats:title>Abstract</jats:title><jats:p><jats:italic>Streptococcus pneumoniae</jats:italic> is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal meningitis and one-third of variation in severity, and identified variants in <jats:italic>CCDC33</jats:italic> associated with susceptibility. Pneumococcal variation explained a large amount of invasive potential, but serotype explained only half of this variation. Newly developed methods identified pneumococcal genes involved in invasiveness including <jats:italic>pspC</jats:italic> and <jats:italic>zmpD</jats:italic>, and allowed a human-bacteria interaction analysis, finding associations between pneumococcal lineage and <jats:italic>STK32C</jats:italic>.</jats:p>

Original publication

DOI

10.1101/386078

Type

Journal article

Publisher

Cold Spring Harbor Laboratory

Publication Date

07/08/2018