Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults

Ogwang C., Kimani D., Edwards NJ., Roberts R., Mwacharo J., Bowyer G., Bliss C., Hodgson SH., Njuguna P., Viebig NK., Nicosia A., Gitau E., Douglas S., Illingworth J., Marsh K., Lawrie A., Imoukhuede EB., Ewer K., Urban BC., S. Hill AV., Bejon P., Leroy O., Cisse B., Sirima S., Bojang K., Murphy G., Karanja H., Nyamako L., De Cassan S., Awuondo K., Kwiatkowski D., Rockett K., Gilbert S., Anagnostou N., Soipei P., Peshu J., Petersen I., Mutinda B., Waithira N., Bashraheil M., Shangala J., Moyle S., Berrie E., Targett G., Thera M., Milligan P., Ogutu B., Etyang A.

Vaccination with the recombinant viral vectors chimpanzee adenovirus 63 followed by modified vaccinia Ankara both encoding the malaria sequence ME-TRAP conferred 67% protection against infection with Plasmodium falciparum in Kenyan adults.

DOI

10.1126/scitranslmed.aaa2373

Type

Journal article

Journal

Science Translational Medicine

Publisher

American Association for the Advancement of Science (AAAS)

Publication Date

06/05/2015

Volume

7

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