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Activation of NKT cells leads to the maturation of dendritic cells and efficiently assists priming of antigen-specific immune responses. The lack of polymorphism of CDld molecules and the evolutionary conservation of NKT cell responses highlight the important role of these cells in bridging innate and adaptive immune responses and advocate the value of harnessing this system in clinical settings. Compounds capable of fine tuning NKT cell activation should be actively exploited as potent adjuvants in vaccination strategies or as immunomodulators of autoimmune diseases.

Original publication

DOI

10.1007/978-3-540-69511-0_13

Type

Journal article

Journal

Current topics in microbiology and immunology

Publication Date

01/2007

Volume

314

Pages

325 - 340

Addresses

Cancer Research UK Tumour Immunology Group, The Weatherall Institute of Molecular Medicine, Oxford OX3 9DS, UK. vincenzo.cerundolo@imm.ox.ac.uk

Keywords

Dendritic Cells, Killer Cells, Natural, Animals, Humans, Mice, Autoimmune Diseases, Adjuvants, Immunologic, Vaccination, Lymphocyte Activation, Cell Differentiation