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Despite universal vaccination of newborns, the prevalence of chronic hepatitis virus B (HBV) infection and the associated disease burden remain high among adults in China. We investigated risk factors for chronic HBV infection in a community-based study of 512,726 individuals aged 30-79 years recruited from ten diverse areas during 2004-2008. Multivariable logistic regression was used to estimate odds ratios (ORs) of hepatitis B surface antigen (HBsAg) positivity recorded at baseline by sociodemographic and lifestyle factors, and medical history. In a random subset (n = 69,898) we further assessed the association of 18 single nucleotide polymorphisms (SNPs) previously shown to be associated with HBsAg positivity and development of chronic liver disease (CLD) (1600 cases). Several factors showed strong associations with HBsAg positivity, particularly younger age (

Original publication

DOI

10.1038/s41598-022-16360-7

Type

Journal article

Journal

Scientific reports

Publication Date

15/07/2022

Volume

12

Addresses

Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, BDI Building, Old Road Campus, University of Oxford, Oxford, OX3 7LF, UK.

Keywords

Humans, Hepatitis B virus, Hepatitis B, Hepatitis B, Chronic, Hepatitis B Surface Antigens, Risk Factors, Adult, Infant, Newborn, China, Male