Vitamin D in Gambian children with discordant tuberculosis (TB) infection status despite matched TB exposure: a case control study.

Stockdale L., Sambou B., Sissoko M., Egere U., Sillah AK., Kampmann B., Basu Roy R.

Using a matched case control design conducted at MRC Gambia in 2015, we measured vitamin D levels in pairs of asymptomatic children with discordant tuberculin skin test status despite the same sleeping proximity to the same adult TB index case. Median ages of groups (infected; 10.0 years, uninfected 8.8 years) were not significantly different (p = 0.13). Mean vitamin D levels were 2.05 ng/mL (95% CI - 0.288 to 4.38) higher in 24 highly TB-exposed uninfected children compared with 24 matched highly TB-exposed infected children (p = 0.08). The findings warrant further investigation in larger studies to understand the implications and significance. Conclusion: Vitamin D levels were higher in TB-uninfected children compared with TB-infected despite equal high exposure to a TB case.

DOI

10.1007/s00431-021-04272-z

Type

Journal article

Journal

European journal of pediatrics

Publication Date

03/2022

Volume

181

Pages

1263 - 1267

Addresses

Department of Paediatrics, University of Oxford, Oxford, UK. lisa.stockdale@ndm.ox.ac.uk.

Keywords

Humans, Tuberculosis, Vitamin D, Tuberculin Test, Case-Control Studies, Adult, Child, Gambia

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