Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Viral variants of concern may emerge with dangerous resistance to the immunity generated by the current vaccines to prevent coronavirus disease 2019 (Covid-19). Moreover, if some variants of concern have increased transmissibility or virulence, the importance of efficient public health measures and vaccination programs will increase. The global response must be both timely and science based.

More information Original publication

DOI

10.1056/nejmsr2105280

Type

Journal article

Publication Date

2021-07-01T00:00:00+00:00

Volume

385

Pages

179 - 186

Total pages

7

Addresses

F, r, o, m, , t, h, e, , O, f, f, i, c, e, , o, f, , V, a, c, c, i, n, e, s, , R, e, s, e, a, r, c, h, , a, n, d, , R, e, v, i, e, w, ,, , C, e, n, t, e, r, , f, o, r, , B, i, o, l, o, g, i, c, s, , E, v, a, l, u, a, t, i, o, n, , a, n, d, , R, e, s, e, a, r, c, h, ,, , F, o, o, d, , a, n, d, , D, r, u, g, , A, d, m, i, n, i, s, t, r, a, t, i, o, n, ,, , S, i, l, v, e, r, , S, p, r, i, n, g, ,, , M, D, , (, P, ., R, ., K, ., ,, , M, ., G, ., ), ;, , t, h, e, , D, e, p, a, r, t, m, e, n, t, , o, f, , B, i, o, s, t, a, t, i, s, t, i, c, s, ,, , U, n, i, v, e, r, s, i, t, y, , o, f, , W, a, s, h, i, n, g, t, o, n, ,, , S, e, a, t, t, l, e, , (, T, ., R, ., F, ., ), ;, , t, h, e, , D, e, p, a, r, t, m, e, n, t, , o, f, , B, i, o, s, t, a, t, i, s, t, i, c, s, ,, , U, n, i, v, e, r, s, i, t, y, , o, f, , F, l, o, r, i, d, a, ,, , G, a, i, n, e, s, v, i, l, l, e, , (, I, ., M, ., L, ., ), ;, , t, h, e, , N, u, f, f, i, e, l, d, , D, e, p, a, r, t, m, e, n, t, , o, f, , P, o, p, u, l, a, t, i, o, n, , H, e, a, l, t, h, ,, , U, n, i, v, e, r, s, i, t, y, , o, f, , O, x, f, o, r, d, , (, R, ., P, ., ,, , V, ., B, ., ), ,, , a, n, d, , t, h, e, , O, x, f, o, r, d, , V, a, c, c, i, n, e, , G, r, o, u, p, ,, , D, e, p, a, r, t, m, e, n, t, , o, f, , P, a, e, d, i, a, t, r, i, c, s, ,, , U, n, i, v, e, r, s, i, t, y, , o, f, , O, x, f, o, r, d, , a, n, d, , N, a, t, i, o, n, a, l, , I, n, s, t, i, t, u, t, e, , f, o, r, , H, e, a, l, t, h, , R, e, s, e, a, r, c, h, , O, x, f, o, r, d, , B, i, o, m, e, d, i, c, a, l, , R, e, s, e, a, r, c, h, , C, e, n, t, r, e, , (, M, ., D, ., S, ., ), ,, , O, x, f, o, r, d, ,, , a, n, d, , t, h, e, , G, l, o, b, a, l, , H, e, a, l, t, h, , P, r, o, g, r, a, m, m, e, ,, , C, h, a, t, h, a, m, , H, o, u, s, e, , (, D, ., L, ., H, ., ), ,, , a, n, d, , t, h, e, , C, o, a, l, i, t, i, o, n, , f, o, r, , E, p, i, d, e, m, i, c, , P, r, e, p, a, r, e, d, n, e, s, s, , I, n, n, o, v, a, t, i, o, n, s, , (, J, ., P, ., C, ., ), ,, , L, o, n, d, o, n, , -, , a, l, l, , i, n, , t, h, e, , U, n, i, t, e, d, , K, i, n, g, d, o, m, ;, , t, h, e, , H, o, w, a, r, d, , C, o, l, l, e, g, e, , S, c, h, o, o, l, , o, f, , L, a, w, ,, , U, n, i, v, e, r, s, i, t, y, , o, f, , K, w, a, Z, u, l, u, -, N, a, t, a, l, ,, , D, u, r, b, a, n, , (, J, ., A, ., S, ., ), ,, , a, n, d, , t, h, e, , W, i, t, s, , R, e, p, r, o, d, u, c, t, i, v, e, , H, e, a, l, t, h, , a, n, d, , H, I, V, , I, n, s, t, i, t, u, t, e, ,, , J, o, h, a, n, n, e, s, b, u, r, g, , (, H, ., R, ., ), , -, , b, o, t, h, , i, n, , S, o, u, t, h, , A, f, r, i, c, a, ;, , t, h, e, , D, a, l, l, a, , L, a, n, a, , S, c, h, o, o, l, , o, f, , P, u, b, l, i, c, , H, e, a, l, t, h, ,, , U, n, i, v, e, r, s, i, t, y, , o, f, , T, o, r, o, n, t, o, ,, , T, o, r, o, n, t, o, , (, J, ., A, ., S, ., ), ;, , t, h, e, , C, l, a, l, i, t, , R, e, s, e, a, r, c, h, , I, n, s, t, i, t, u, t, e, ,, , I, n, n, o, v, a, t, i, o, n, , D, i, v, i, s, i, o, n, ,, , C, l, a, l, i, t, , H, e, a, l, t, h, , S, e, r, v, i, c, e, s, ,, , T, e, l, , A, v, i, v, ,, , I, s, r, a, e, l, , (, R, ., D, ., B, ., ), ;, , t, h, e, , B, e, r, n, h, a, r, d, , N, o, c, h, t, , I, n, s, t, i, t, u, t, e, , f, o, r, , T, r, o, p, i, c, a, l, , M, e, d, i, c, i, n, e, ,, , H, a, m, b, u, r, g, ,, , G, e, r, m, a, n, y, , (, C, ., M, ., -, F, ., ), ;, , t, h, e, , W, o, r, l, d, , H, e, a, l, t, h, , O, r, g, a, n, i, z, a, t, i, o, n, , C, o, l, l, a, b, o, r, a, t, i, n, g, , C, e, n, t, r, e, , f, o, r, , R, e, f, e, r, e, n, c, e, , a, n, d, , R, e, s, e, a, r, c, h, , o, n, , I, n, f, l, u, e, n, z, a, ,, , P, e, t, e, r, , D, o, h, e, r, t, y, , I, n, s, t, i, t, u, t, e, , f, o, r, , I, n, f, e, c, t, i, o, n, , a, n, d, , I, m, m, u, n, i, t, y, ,, , M, e, l, b, o, u, r, n, e, ,, , V, I, C, ,, , A, u, s, t, r, a, l, i, a, , (, K, ., S, ., ), ;, , a, n, d, , t, h, e, , W, o, r, l, d, , H, e, a, l, t, h, , O, r, g, a, n, i, z, a, t, i, o, n, ,, , G, e, n, e, v, a, , (, S, ., B, ., ,, , A, ., -, M, ., R, ., ,, , R, ., G, ., ,, , M, ., D, ., V, ., K, ., ,, , S, ., S, ., ,, , M, ., J, ., R, ., ,, , A, ., -, M, ., H, ., -, R, ., ), .

Keywords

Humans, Virulence, Mutation, Spike Glycoprotein, Coronavirus, Immunogenicity, Vaccine, COVID-19, SARS-CoV-2, COVID-19 Vaccines