Other Seminars

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Tue 1 Oct 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Spatial enhancer-promoter networks in pluripotent stem cells

Dr Stefan Schoenfelder

Audience: Members of the University only

Organisers: Liz Rose

Wed 2 Oct 2019 from 11:00 to 12:30

Ethox Centre and Wellcome Centre for Ethics and Humanities

Big Data Institute, L1 Ax Meeting Room, Old Road Campus OX3 7LF

Ethox/WEH Seminar - Reclaiming a Sense of Common Humanity: A Confucian Ethical Vision

Professor Jing-Bao Nie

The idea of a common humanity constitutes a foundational ethical perception across the centuries and geographical boundaries. However, from the first half of twentieth century and in spite of sweeping globalization, such a moral sense has been substantially undermined -- at times totally shattered... Read more

The idea of a common humanity constitutes a foundational ethical perception across the centuries and geographical boundaries. However, from the first half of twentieth century and in spite of sweeping globalization, such a moral sense has been substantially undermined -- at times totally shattered -- by a series of events of inhumanity, socio-political forces and intellectual movements including wartime medical atrocities, nationalism, postmodernism and multiculturalism. This talk aims to demonstrate how a sense of common humanity should and can be reclaimed, or in the Confucian term, cultivated through engaging with thought of Meng Zi (Mencius, c. 372-289 BCE), a founder of Confucianism, and traditional Chinese medical ethics on moral sentiments and universalism.

Booking Required

Audience: Members of the University only

Organisers: Christa Henrichs

Wed 2 Oct 2019 from 14:30 to 15:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

NO TIME TO DIE: how herpesviruses and host ensure their survival

Prof. Melanie Brinkmann

Audience: Members of the University only

Organisers: Anne Farmer

Thu 3 Oct 2019 from 09:30 to 10:30

NDM Building, Seminar Room, Headington OX3 7FZ

The way forward to HIV vaccine development

Barton F. Haynes

Bart Haynes is a leader in HIV Vaccine development and heads the NIH Center for HIV/AIDS Vaccine Development. He has made many seminal contributions on understanding how HIV Envelope evolves during infection, selected by a mutating antibody response. He has unravelled how broadly neutralizing... Read more

Bart Haynes is a leader in HIV Vaccine development and heads the NIH Center for HIV/AIDS Vaccine Development. He has made many seminal contributions on understanding how HIV Envelope evolves during infection, selected by a mutating antibody response. He has unravelled how broadly neutralizing antibodies develop, how they bind to the Envelope and what regulates these immune responses. His programme aims to get Envelope based vaccines that stimulate broadly neutralizing antibodies into clinical trial within five years. Liao HX, …….. Mascola, J.R., Haynes BF. Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus. Nature. 2013;496(7446):469-76 Bonsignori M, …….., Kwong PD, Haynes BF. Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody. Cell. 2016;165(2):449-63.

Audience: Members of the University only

Fri 4 Oct 2019 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Using the immune system’s Trojan horse for vaccination

Dr Lise Chauveau

Audience: Members of the University only

Organisers: Anne Farmer

Fri 4 Oct 2019 from 11:00 to 12:00

Strubi seminars

From the structure of vertebrate and invertebrate rhodopsins to new applications in optogenetics

Prof Gebhard F.X. Schertler

Professor for Structural Biology ETH Zürich D-BIOL and Head of Biology and Chemistry Division, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland In this project, we explore the use of light-sensitive G protein-coupled receptors (GPCRs) ¬–opsins– for the development of new optogenetic... Read more

Professor for Structural Biology ETH Zürich D-BIOL and Head of Biology and Chemistry Division, Paul Scherrer Institut, 5232 Villigen PSI, Switzerland In this project, we explore the use of light-sensitive G protein-coupled receptors (GPCRs) ¬–opsins– for the development of new optogenetic tools to control cellular signalling processes using light: opto-GPCRs. In a first stage we identified several new opsins capable of GPCR pathways. We extensively characterized the most promising candidate opsins biochemically in cellular assays and finally in vivo. We developed the basis for engineering bistable opsins towards more effective optogenetic tools. For this, we determined the first structure of a recombinant invertebrate rhodopsin, carried out a detailed study of the chromophore binding site with advanced biophysical methods. We were able to compare in detail monostable and bistable visual pigments. The bistable pigments in several aspects are closer to the ligand binding pharmacologically relevant family A GPCRs. In a successful engineering attempt, we were able to identify mutations that shift the wavelengths of an invertebrate rhodopsin towards the infrared. This is important for the penetration of the light into tissues. The engineered opto-GPCRs are an important alternative to the channel opsins related optogenetic tools and they have a wide range of applications that is not restricted to neurons. C. Tsai, J. Marino, R. Adaixo, F. Pamula, J. Muehle, S. Maeda, T. Flock, N. Taylor, I. Mohammed, H. Matile, R. Dawson, X. Deupi, H. Stahlberg, G. Schertler: Cryo-EM structure of the rhodopsin-Gαi-βγ complex reveals binding of the rhodopsin C-terminal tail to the gβ subunit. eLife 8 (2019) T. Nagata, M. Koyanagi, R. Lucas and A. Terakita: An all-trans-retinal-binding opsin peropsin as a potential dark-active and light-inactivated G protein-coupled receptor. Sci. Rep. 8, 3535 (2018) E. Gerrard, E. Mutt, T. Nagata, M. Koyanagi, T. Flock, E. Lesca, G. F. X. Schertler, A. Terakita, X. Deupi, R. Lucas: Convergent evolution of tertiary structure in rhodopsin visual proteins from vertebrates and box jellyfish. Proceedings of the National Academy of Sciences (USA) 115(24):6201-6206 (2018) T. Nagata, M. Koyanagi, H. Tsukamoto, E. Mutt, G. F. X. Schertler, X. Deupi, A. Terakita: The counterion–retinylidene Schiff base interaction of an invertebrate rhodopsin rearranges upon light activation. Communications biology 2 (1), 180 (2019) D. Ehrenberg, N. Varma, X. Deupi, M. Koyanagi, A. Terakita, G.F.X. Schertler, J. Heberle, E. Lesca: The two-photon reversible reaction of the bistable jumping spider rhodopsin-1. Biophysical journal 116 (7), 1248-1258 (2019) N. Varma, E. Mutt, 1, J. Mühle, V. Panneels, A. Terakita, X. Deupi, P. Nogly, G.F.X. Schertler, E. Lesca: Crystal structure of a light-sensitive bistable class A GPCR. Proceedings of the National Academy of Sciences, 201902192 (2019)

Audience: Members of the University only

Organisers: Agata Krupa

Fri 4 Oct 2019 from 16:00 to 17:00

Development & Cell Biology Theme Guest Speakers (DPAG)

Sherrington Library, off Parks Road OX1 3PT

* CANCELLED * (CANCELLED) The dynamics of cell identity: explorations in mammalian embryos

Anna-Katerina Hadjantonakis

Developmental and stem cell biologist Anna-Katerina (Kat) Hadjantonakis is a Member of the Developmental Biology Program at the Sloan Kettering Institute and a Professor at Cornell University in New York, USA. Her lab seeks to understand how cells regulate their identity, and how they coordinately... Read more

Developmental and stem cell biologist Anna-Katerina (Kat) Hadjantonakis is a Member of the Developmental Biology Program at the Sloan Kettering Institute and a Professor at Cornell University in New York, USA. Her lab seeks to understand how cells regulate their identity, and how they coordinately and reproducibly build complex organs in mammalian embryos, and in in vitro stem cell and organoid models. She received a BSc in Biochemistry in 1990, and PhD in Molecular Genetics in 1995, from Imperial College London, UK. She then undertook postdoctoral training, first with Drs. Andras Nagy at the Lunenfeld-Tanenbaum Research Institute, Toronto, Canada, and thereafter with Dr. Virginia Pappaioannou at Columbia University, New York, USA. She established her independent research group at Sloan Kettering in 2004. She currently serves on the editorial boards of journals including Developmental Cell, Development and Developmental Biology. She is a standing member of grant review panels and advisory committees for the NIH, the NSF, the UK’s Wellcome Trust, and the European Research Council.

Audience: Members of the University only

Organisers: Katherine McNeil

Mon 7 Oct 2019 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7FY

Single-cell and epigenetic approaches to define and regulate macrophages in atherosclerosis

Professor Menno de Winther

In our work we are pursuing a better understanding of macrophage functioning in atherosclerosis and identification of approaches to suppress their detrimental effects in disease. In my talk I will discuss our recent progress using single cell RNAseq of human atherosclerotic plaques to define immune... Read more

In our work we are pursuing a better understanding of macrophage functioning in atherosclerosis and identification of approaches to suppress their detrimental effects in disease. In my talk I will discuss our recent progress using single cell RNAseq of human atherosclerotic plaques to define immune cell populations and their characteristics. Moreover, we are performing studies to identify epigenetic enzymes that are relevant in regulating macrophages in atherosclerotic disease.

Audience: Public

Organisers: Jennifer Pope

Mon 7 Oct 2019 from 13:00 to 14:00

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Human Dendritic Cell Subsets in the High-Dimensional Era

Prof. Juliana Idoyaga

Audience: Members of the University only

Organisers: Anne Farmer

Mon 7 Oct 2019 from 14:00 to 15:00

Department of Oncology

Old Road Campus Research Building, Ludwig seminar room, basement of ORCRB, Headington OX3 7DQ

Clinical relevance of hyper-recombination in cancer

Dr. Anand Jeyasekharan

Audience: Members of the University only

Organisers: Jade Schneiders

Tue 8 Oct 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Innate host defence: a playing field for the ubiquitin machinery

Dr Mads Gyrd-Hansen

Audience: Members of the University only

Organisers: Liz Rose

Wed 9 Oct 2019 from 09:30 to 10:30

Tropical Medicine Seminars

NDM Building, Basement seminar room, Headington OX3 7FZ

TropMed webinar: Mapping and Tracking Malaria

Prof Arjen Dondorp, Dr Susan Rumisha

Arjen Dondorp will speak about multidrug resistant falciparum malaria and triple artemisinin combination therapies. Susan Rumisha will tell us about the global modeling of antimalarial drugs efficacy for the treatment of uncomplicated Plasmodium falciparum malaria, from 1991 to 2019

Arjen Dondorp will speak about multidrug resistant falciparum malaria and triple artemisinin combination therapies. Susan Rumisha will tell us about the global modeling of antimalarial drugs efficacy for the treatment of uncomplicated Plasmodium falciparum malaria, from 1991 to 2019

Audience: Members of the University only

Organisers: Claire-Lise Kessler

The seminar will be shared via Zoom. Contact Claire-Lise Kessler if you want to join

Thu 10 Oct 2019 from 13:00 to 14:00

Medical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Cardiology / Rheumatology

Dr Laura Coates, Prof Rajesh Kharbanda, Dr Jim Newton

Cardiology: "Valve disease – some sticky cases", Prof Rajesh Kharbanda and Dr Jim Newton -- Rheumatology: "Psoriatic arthritis – a pain in the backside", Dr Laura Coates -- Chair: Prof Richard Cornall

Cardiology: "Valve disease – some sticky cases", Prof Rajesh Kharbanda and Dr Jim Newton -- Rheumatology: "Psoriatic arthritis – a pain in the backside", Dr Laura Coates -- Chair: Prof Richard Cornall

Audience: Members of the University and NHS clinical staff.

Thu 10 Oct 2019 from 13:30 to 14:30

ARUK Oxford Drug Discovery Institute Seminar Series

NDM Building, Seminar room, Headington OX3 7FZ

Modelling Microglia to Understand Neurodegeneration and Aging

Professor David Brown

Audience: Members of the University only

Organisers: Kate Humphrey

Thu 10 Oct 2019 from 14:15 to 15:15

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

MRC: priorities and funding opportunities

Dr Martin Broadstock

Audience: Members of the University only

Organisers: Anne Farmer

Fri 11 Oct 2019 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Colonic CD8+ remodelling in IBD

Dr Daniele Corridoni

Audience: Members of the University only

Organisers: Anne Farmer

Fri 11 Oct 2019 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley LEcture Theatre, Headington OX3 7FY

Altered Lymphatic Transport in Chronic Inflammatory Disease

Professor Gwendalyn Randolph

Audience: Members of the University only

Organisers: Jennifer Pope

Mon 14 Oct 2019 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7FY

In search of the macrophage niche

Professor Martin Guilliams

Most tissue-resident macrophages are derived from embryonic precursors but, under certain circumstances, circulating monocytes can differentiate into self-maintaining tissue-resident macrophages that closely resemble their embryonic counterparts. We propose that distinct macrophage precursors have... Read more

Most tissue-resident macrophages are derived from embryonic precursors but, under certain circumstances, circulating monocytes can differentiate into self-maintaining tissue-resident macrophages that closely resemble their embryonic counterparts. We propose that distinct macrophage precursors have a comparable potential to develop into resident macrophages but that they compete for a restricted number of niches. Imprinting by the niche would be the dominant factor conferring macrophage identity and self-maintenance capacity. We have recently shown that circulating monocytes can efficiently differentiate into Kupffer cells (KCs), the liver-resident macrophages. Using knock-in mice that allow specific KC depletion, we found that monocytes colonize the KC niche in a single wave upon KC depletion and rapidly differentiate into self-maintaining KCs that are transcriptionally and functionally identical to embryonic KCs. This implies that: (i) access to the KC niche is tightly regulated ensuring that monocytes do not differentiate into KCs when the KC niche is full but differentiate very efficiently into KCs upon temporary niche availability, (ii) imprinting by the KC niche is the dominant factor conferring KC identity. But which cells represent this enigmatic niche? Which cells recruit the monocytes? Why is this phenomenon so transient? How is this triggered and terminated? And which signals produced by the macrophage niche imprint the tissue-specific macrophage gene expression profile and through which transcription factors is this mediated? We utilize a research strategy that combines in silico bio-informatics approaches and unique in vivo transgenic mouse models to tackle this challenge specifically for KCs, the most abundant macrophage in the body and one of the oldest immune cells known to man.

Audience: Public

Organisers: Jennifer Pope

Mon 14 Oct 2019 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Human immune systems are shaped by environmental exposures early in Life

Assoc Prof Petter Brodin

Audience: Members of the University only

Organisers: Liz Cloke

Mon 14 Oct 2019 from 15:00 to 16:00

BDI seminars

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

Phenome@BDI Seminar - Brain imaging in the UK Biobank: Discovery science to hypothesis-driven research

Professor Karla Miller

The UK Biobank is currently conducting the most ambitious imaging study ever undertaken, scanning 100,000 subjects, with brain imaging as a key component. In this talk, I'll overview the Biobank neuroimaging resource, which includes six separate imaging modalities. I'll then present several studies... Read more

The UK Biobank is currently conducting the most ambitious imaging study ever undertaken, scanning 100,000 subjects, with brain imaging as a key component. In this talk, I'll overview the Biobank neuroimaging resource, which includes six separate imaging modalities. I'll then present several studies that highlight how this resource is already revolutionising the neuroimaging field by enabling both discovery science and hypothesis-driven research that previously would not have been possible.

Audience: Members of the University only

Mon 14 Oct 2019 from 16:00 to 17:00

Burdon Sanderson Cardiac Science Centre Lecture Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Cardiovascular diseases and drugs: hiPSC models moving forward

Christine Mummery

Cardiovascular cells derived from hPSC are of growing interest for drug discovery and toxicity. Our lab has been investigating microphysiological solutions using multicellular cardiac microtissues to quantify the outcomes of drug and disease mutation responses in situ. Isogenic pairs of hiPSC have... Read more

Cardiovascular cells derived from hPSC are of growing interest for drug discovery and toxicity. Our lab has been investigating microphysiological solutions using multicellular cardiac microtissues to quantify the outcomes of drug and disease mutation responses in situ. Isogenic pairs of hiPSC have proven essential to compensate interline variability. We have shown that iPSC derived cardiomyocytes with mutations in ion channel genes can accurately predict changes in cardiac electrical properties and reveal drug sensitivities also observed in patients. Biography: Christine Mummery studied physics at the University of Nottingham, UK and has a PhD in Biophysics from the University of London. After positions as postdoc and tenured group leader at the Hubrecht Institute, she became professor at the University Medical Centre Utrecht in 2002. After a sabbatical at the Harvard Stem Cell Institute in 2007, she introduced human iPS cells to the Netherlands. In 2008, she became Professor of Developmental Biology at Leiden University Medical Centre in the Netherlands and head of the Department of Anatomy and Embryology. Her research concerns heart development and the differentiation of pluripotent human stem cells into the cardiac and vascular lineages and using these cells as disease models, for safety pharmacology and drug discovery. Immediate interests are on developing biophysical techniques for characterization and functional analysis of cardiovascular cells from hPSC. In 2015 she became guest professor at the Technical University of Twente to develop organ-on-chip models. She was recently awarded a multimillion grant for this purpose and is awardee of a prestigious European Research Council Advanced Grant. She is a member of the Royal Netherlands Academy of Science (KNAW), and board member and incoming president of the International Society of Stem Cell research (ISSCR); she is also former board of the KNAW and the Netherlands Medical Research Council (ZonMW). She was awarded the Hugo van de Poelgeest Prize for Animal Alternatives in research, has co-authored a popular book on stem cells “Stem Cells: scientific facts and Fiction” (2nd edition 2014) and is editor in chief of the ISSCR journal Stem Cell Reports. She is also on the editorial boards of Cell Stem Cell, Cardiovascular Research and Stem Cells.

Audience: Members of the University only

Mon 14 Oct 2019 from 17:00 to 18:00

Oxford Martin School Public Lectures

Oxford Martin School, Corner of Catte and Holywell Streets, 34 Broad Street OX1 3BD

The technology trap - capital, labour and power in the age of automation

Dr Carl Benedikt Frey

In this book talk the Author, Carl Benedikt Frey, will discuss how the Industrial Revolution was a defining moment in history, but how few grasped its enormous consequences at the time. Now that we are in the midst of another technological revolution how can the lessons of the past can help us to... Read more

In this book talk the Author, Carl Benedikt Frey, will discuss how the Industrial Revolution was a defining moment in history, but how few grasped its enormous consequences at the time. Now that we are in the midst of another technological revolution how can the lessons of the past can help us to more effectively face the present? This talk will be followed by a book sale, signing and drinks reception. All welcome.

Booking Required

Audience: Public

Organisers: Oxford Martin School

Tue 15 Oct 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Does nuclear size matter? Abnormal megakaryocyte polyploidization and maturation in myelofibrosis

Rong Li

Audience: Members of the University only

Organisers: Liz Rose

Tue 15 Oct 2019 from 13:00 to 14:00

Population Health Seminars

Big Data Institute, Seminar rooms, Old Road Campus OX3 7LF

Richard Doll Seminar - A longitudinal view of diabetes and its complications

Professor Daniel Witte

Audience: Members of the University only

Organisers: Graham Bagley

Tue 15 Oct 2019 from 16:00 to 17:00

OPDC Seminar Series (DPAG)

Sherrington Library, off Parks Road OX1 3PT

Striatal synaptic dysfunction in Parkinson's disease

Professor Paolo Calabresi

In the last two decades, Prof. Calabresi’s research has investigated the synaptic communication between the cerebral cortex and the basal ganglia, focussing on corticostriatal synapses and their activity-dependent plasticity. In particular, Prof. Calabresi’s group has extensively investigated... Read more

In the last two decades, Prof. Calabresi’s research has investigated the synaptic communication between the cerebral cortex and the basal ganglia, focussing on corticostriatal synapses and their activity-dependent plasticity. In particular, Prof. Calabresi’s group has extensively investigated how corticostriatal communication depends on the activation of dopamine receptors and how it is affected by pathological conditions such as Parkinson’s disease. The research group coordinated by Prof. Calabresi has been the first, in 1992, to describe a novel form of striatal synaptic plasticity, named long-term-depression (LTD). This vital feature of corticostriatal synapses has then be synaptic plasticity, named long-term-depression (LTD). This vital feature of corticostriatal synapses has then been fully characterised by Prof Calabresi’s group from a pharmacological and electrophysiological point of view.

Audience: Members of the University only

Organisers: Professor Richard Wade-Martins

Wed 16 Oct 2019 from 12:00 to 13:00

Peter Medawar Building Seminars

Zoology Research and Administration Centre, Seminar room

Moving forward with spatial disease models: Movement ecology improves predictions for disease spread

David Daversa

Global change is altering patterns of wildlife movement, and in turn, how they spread parasites over the landscape. Infectious disease outbreaks from parasite spread threaten public health and biodiversity. Yet, there remains much uncertainty over the extent to which wildlife movements contribute... Read more

Global change is altering patterns of wildlife movement, and in turn, how they spread parasites over the landscape. Infectious disease outbreaks from parasite spread threaten public health and biodiversity. Yet, there remains much uncertainty over the extent to which wildlife movements contribute to parasite spread that hinders disease control efforts. For this talk, I will present a new model for predicting the impact of host migrations, dispersal and other movements on the spatial spread of parasites, and use the model to explain the factors that determine whether wildlife movements facilitate or inhibit parasite spread. I will also present my field and experimental studies of amphibians that quantified the effect of their movements on the dynamics of the fungal parasite, Batrachochytrium dendrobatidis.

Audience: Members of the University only

Organisers: Suki Kenth

Wed 16 Oct 2019 from 12:30 to 13:30

WHG Lunchtime Lab Talks

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

Bhattacharya & Church Lunchtime Lab Talks

Christopher Lynch, Yannick Comoglio, Lingyun Xiong

Bhattacharya Group Speaker: Christopher Lynch Title: ‘Targeting the chemokine network in myocarditis using ligand traps derived from tick saliva’ Church Group Speaker 1: Yannick Comoglio Title: ‘VEGFC is an unexpected negative regulator of pediatric medulloblastoma... Read more

Bhattacharya Group Speaker: Christopher Lynch Title: ‘Targeting the chemokine network in myocarditis using ligand traps derived from tick saliva’ Church Group Speaker 1: Yannick Comoglio Title: ‘VEGFC is an unexpected negative regulator of pediatric medulloblastoma aggressiveness’ Speaker 2: Lingyun Xiong Title: ‘Inherited and somatic genetic variants in the p53 pathway interact to affect cancer risk and progression’

Audience: Members of the University only

Organisers: Isabel Schmidt

Thu 17 Oct 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, NDMRB (TDI) seminar room, Headington OX3 7FZ

“A multifaceted interplay between metabolism and epigenetics determines how CAFs remodel the tumour stroma”

Professor Sara Zanivan

Audience: Members of the University only

Organisers: Alexandra Ward

Thu 17 Oct 2019 from 11:00 to 12:00

Strubi seminars

Wellcome Trust Centre for Human Genetics, Meeting room A , Headington OX3 7BN

Dr Ilaria Ferlenghi "An Integrated structural and digital approach for vaccine identification and pathogenesis insight"

The selection in silico of vaccine candidates by Reverse Vaccinology can be challenged by: sequence variability of the pathogens, the immune evasion strategies adopted by the pathogens, the low abundance of surface antigens and eventually their low stability once expressed as recombinant antigens.... Read more

The selection in silico of vaccine candidates by Reverse Vaccinology can be challenged by: sequence variability of the pathogens, the immune evasion strategies adopted by the pathogens, the low abundance of surface antigens and eventually their low stability once expressed as recombinant antigens. These challenges can be faced with a deep knowledge of the three-dimensional structure of the candidates. The advances in cryo-EM together with well-set X-ray crystallography and HDx-MS allowed recently the structural characterization of a huge amount of new proteins. The use of 3D protein structures similarity is a key tool in the highly specific antigen identification. We generate and compare 3D protein structure by the Structure Similarity Algorithm GEMINI running in a dedicated freely available GSK repository that contains internally generated structures as well as publicly available structure related databases and literature data.

Audience: Members of the University only

Organisers: Agata Krupa

Thu 17 Oct 2019 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, 1st Floor meeting room, Old Road Campus OX3 7LF

Thu 17 Oct 2019 from 13:00 to 14:00

Medical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Neurology / Psychological Medicine

Prof Peter Rothwell, Prof Michael Sharpe

Neurology: "Wolfson Centre for Prevention of Stroke and Dementia: Is prevention really possible?", Prof Peter Rothwell -- Psychological Medicine: "The myth(s) of mental illness", Prof Michael Sharpe -- Chair: Prof Chris O'Callaghan

Neurology: "Wolfson Centre for Prevention of Stroke and Dementia: Is prevention really possible?", Prof Peter Rothwell -- Psychological Medicine: "The myth(s) of mental illness", Prof Michael Sharpe -- Chair: Prof Chris O'Callaghan

Audience: Members of the University and NHS clinical staff.

Fri 18 Oct 2019 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Talking to cancer patients - do not promise what you cannot deliver

Professor Michael Griffin OBE

Professor Michael Griffin OBE became President of the Royal College of Surgeons of Edinburgh in 2018, when he was a Consultant Oesophagogastric surgeon at the Royal Victoria Infirmary. He developed the Northern Oesophagogastric Cancer Unit which is now the largest in Europe and North America. A... Read more

Professor Michael Griffin OBE became President of the Royal College of Surgeons of Edinburgh in 2018, when he was a Consultant Oesophagogastric surgeon at the Royal Victoria Infirmary. He developed the Northern Oesophagogastric Cancer Unit which is now the largest in Europe and North America. A Council member since 2009, he is Chair of the Joint Committee for Intercollegiate Examinations (JCIE) and Professor of Gastrointestinal Surgery at the University of Newcastle upon Tyne. His clinical and research interests have been focused on early diagnosis and radical treatment of oesophagogastric cancers. He was awarded an OBE for services to cancer health care in 2013.

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 18 Oct 2019 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Malaria Vaccines – Every Antibody Counts!

Prof Simon Draper, Dr David Pulido-Gomez

Audience: Members of the University only

Organisers: Anne Farmer

Fri 18 Oct 2019 from 11:00 to 12:00

Strubi seminars

Wellcome Trust Centre for Human Genetics, Meeting rooms A & B, Headington OX3 7BN

"Erythrocyte membrane remodelling and destruction by malaria parasites"

Helen Saibil

In the clinical phase of malaria infection, the parasite cells (merozoites) invade their host erythrocytes and create an intracellular vacuole, inside which they replicate. In addition, they modify the erythrocyte membrane to create sites of adhesion to endothelia, the cause of severe clinical... Read more

In the clinical phase of malaria infection, the parasite cells (merozoites) invade their host erythrocytes and create an intracellular vacuole, inside which they replicate. In addition, they modify the erythrocyte membrane to create sites of adhesion to endothelia, the cause of severe clinical disease in P. falciparum cases. When the daughter parasites are mature, after about 48 h, they need to break through both vacuole and erythrocyte membranes in order to invade new erythrocytes. The process by which they escape (“egress”) is a highly ordered sequence of secretion, activation and proteolytic events, culminating in explosive release of the new parasites for the next round of infection. We have used video microscopy, electron and X-ray tomography along with mutants and pharmacological blockers of different steps in egress, to study membrane disruption and breakage during the process of egress. This work has revealed new steps in egress and an unexpected role for the major merozoite surface complex MSP1.

Audience: Members of the University only

Organisers: Agata Krupa

Fri 18 Oct 2019 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Neurovascular interactions during CNS development

Professor Amparo Acker-Palmer

The development of the nervous and the vascular systems exhibit extensive similarities, both on the anatomical and the molecular level. Blood vessels and nerves are structurally similar and often aligned, following parallel routes. The brain is the most vascularized tissue in our body. In the past,... Read more

The development of the nervous and the vascular systems exhibit extensive similarities, both on the anatomical and the molecular level. Blood vessels and nerves are structurally similar and often aligned, following parallel routes. The brain is the most vascularized tissue in our body. In the past, we have discovered that the same molecular mechanisms are used to orchestrate the development of the nervous and the vascular system. It is now believed that blood vessels in the brain exert instructive functions that go beyond supplying nutrients and oxygen, for example supplying ligands that directly influence neuronal behavior by activating corresponding receptors and signaling pathways in neuronal cells. We are interested in elucidating the molecular pathways involved in the crosstalk between vessels and nerves and how this crosstalk signaling is integrated among the different cellular players (neurons, endothelial cells, astrocytes) at the neurovascular interface during CNS development and during adult functions such as blood brain barrier maintenance and synaptic plasticity. References: 1. Segarra et al. (2018) Endothelial Dab1 signaling orchestrates neuro-glia-vessel communication in the central nervous system. Science 361:6404 2. Pfennig et la., (2017) GRIP1 Binds to ApoER2 and EphrinB2 to Induce Activity-Dependent AMPA Receptor Insertion at the Synapse. Cell Reports 21:84-96 3. Geiger et al., (2014) The GRIP1/14-3-3 pathway coordinates cargo trafficking and dendrite development. Dev Cell 28: 381-393. 4. Senturk et al (2011) EphrinBs are essential components of the Reelin pathway to regulate neuronal migration. Nature, 472:356-60; 478:274 5. Sawamiphak et al., (2010) EphrinB2 regulates VEGFR2 function in developmental and tumour angiogenesis Nature 465:487–491 6. Essmann et al., (2008) Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors. Nature Neuroscience 11:1035 – 1043 7. Segura et al (2007) Grb4 and GIT1 transduce ephrinB reverse signals modulating spine morphogenesis and synapse formation. Nature Neuroscience 10: 301-310.

Audience: Members of the University only

Organisers: Professor Maike Glitsch

Fri 18 Oct 2019 from 13:30 to 14:30

Jenner Seminars

NDM Building, Seminar Room, Lower Ground Floor, Headington OX3 7FZ

* CANCELLED * SEMINAR POSTPONED - New date will be circulated shortly

Dr Mark Feinberg

Audience: Public

Organisers: Lisbeth Soederberg

Fri 18 Oct 2019 from 17:00 to 18:00

Oxford Martin School Public Lectures

Oxford Martin School, Corner of Catte and Holywell Streets, 34 Broad Street OX1 3BD

Psychologically informed micro-targeted political campaigns: the use and abuse of data

Dr Jens Koed Madsen

Data-driven micro-targeted campaigns have become a main stable of political strategy. As personal and societal data becomes more accessible, we need to understand how it can be used and mis-used in political campaigns and whether it is relevant to regulate political candidates’ access to data. This book talk will be followed by a drinks reception and book sale, all welcome.

Data-driven micro-targeted campaigns have become a main stable of political strategy. As personal and societal data becomes more accessible, we need to understand how it can be used and mis-used in political campaigns and whether it is relevant to regulate political candidates’ access to data. This book talk will be followed by a drinks reception and book sale, all welcome.

Booking Required

Audience: Public

Organisers: Oxford Martin School

Mon 21 Oct 2019 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7FY

Environment control of T cell function

Professor Doreen Cantrell

The T lymphocyte response to pathogens is shaped by the T cell microenvironment and key environmental signals are provided by amino acids, glucose and oxygen. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and... Read more

The T lymphocyte response to pathogens is shaped by the T cell microenvironment and key environmental signals are provided by amino acids, glucose and oxygen. Environmental sensors in T cells include the nutrient-sensing serine/threonine kinases, adenosine monophosphate-activated protein kinase and mammalian target of rapamycin complex 1 and signaling pathways regulated by intracellular protein O-GlcNAcylation. Other environmental sensors are transcription factors such as c-myc and hypoxia-inducible factor-1 alpha.The present talk will explore the molecular basis for the impact of environmental signals on the differentiation of conventional T cell receptor αβ T cells and how the T cell response to immune stimuli can coordinate the T cell response to environmental cues.

Audience: Public

Organisers: Jennifer Pope

Mon 21 Oct 2019 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

C1q in health and disease – roles outside the complement system

Prof Marina Botto

Audience: Members of the University only

Organisers: Liz Cloke

Mon 21 Oct 2019 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, CEU Meeting Room, Old Road Campus OX3 7LF

NDPH Special Seminar - Could cigarette smoking really protect against a few types of cancer?

Dr John A. Baron

Audience: Members of the University only

Organisers: Graham Bagley

Tue 22 Oct 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Single-cell analysis of structural variations and complex rearrangements with tri-channel-processing

Dr Jan Korbel

Audience: Members of the University only

Organisers: Liz Rose

Tue 22 Oct 2019 from 13:00 to 14:00

Population Health Seminars

Big Data Institute, Seminar rooms, Old Road Campus OX3 7LF

Richard Doll Seminar - Chronic kidney disease of unknown cause: the epidemic you’ve never heard of

Professor Neil Pearce

Audience: Members of the University only

Organisers: Graham Bagley

Wed 23 Oct 2019 from 10:00 to 11:40

Old Road Campus Research Building, Seminar Room 71a, Headington OX3 7DQ

The Conversation - training sessions for researchers

Editor of The Conversation

Have you thought about writing for The Conversation (https://theconversation.com/uk) but aren't sure how it works? If the answer is YES, register for this training session with an Editor from The Conversation to find out more. The session will include an 'Introduction to The Conversation', followed... Read more

Have you thought about writing for The Conversation (https://theconversation.com/uk) but aren't sure how it works? If the answer is YES, register for this training session with an Editor from The Conversation to find out more. The session will include an 'Introduction to The Conversation', followed by an interactive workshop on 'Writing for a Public Audience', with opportunity for questions. There are also a small number of 20 minute one-to-one sessions with the editor available.This may be useful if you have an idea for a story but would like to some advice on how best to pitch it. The editor can give you a steer and encouragement on the best angles for turning your research and expertise into articles. Please register your interest on the link below and we will be in contact with you. These are available on a strict first come, first served basis. To find out more about The Conversation, please visit www.ox.ac.uk/research/support-researchers/using-research-engage/conversation.

Booking Required

Audience: Members of the University only

Organisers: Janice Young

Wed 23 Oct 2019 from 12:00 to 13:00

Peter Medawar Building Seminars

Zoology Research and Administration Centre, Seminar room

Ebola virus: Vaccines, survivors and molecular epidemiology

Miles Carroll

The 2013-2016 West African Ebola virus outbreak had devastating effects on the local region. However, the large number of Ebola virus disease cases has allowed researchers to assess; the efficacy of novel vaccines, characteristics of naturally acquired immunity and the existence of sub-symptomatic... Read more

The 2013-2016 West African Ebola virus outbreak had devastating effects on the local region. However, the large number of Ebola virus disease cases has allowed researchers to assess; the efficacy of novel vaccines, characteristics of naturally acquired immunity and the existence of sub-symptomatic infections. Additionally, as it was the most extensively sequenced outbreak in history it has provided opportunities to assess virus mutation patterns and develop tools to support molecular epidemiology. The seminar will include an overview of a unique longitudinal analysis of two cohorts of survivors in Guinea and compare naturally acquired and vaccine induced immunity. Aspects of the utility of real-time field sequencing of EBOV in an outbreak setting will also be described.

Audience: Members of the University only

Organisers: Suki Kenth

Please arrive 5 minutes before the start of the seminar to gain entrance

Wed 23 Oct 2019 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Metabolic control of Natural Killer Cell anti-tumour responses

Professor David Finlay

Audience: Members of the University only

Organisers: Anne Farmer

Wed 23 Oct 2019 from 14:00 to 15:40

Sir William Dunn School of Pathology, EPA Seminar Room, South Parks Road OX1 3RE

The Conversation - training sessions for researchers

Editor of The Conversation

Have you thought about writing for The Conversation (https://theconversation.com/uk) but aren't sure how it works? If the answer is YES, register for this training session with an editor from the The Conversation to find out more. The session will include an 'Introduction to The Conversation',... Read more

Have you thought about writing for The Conversation (https://theconversation.com/uk) but aren't sure how it works? If the answer is YES, register for this training session with an editor from the The Conversation to find out more. The session will include an 'Introduction to The Conversation', followed by an interactive workshop on 'Writing for a Public Audience', with opportunity for questions. There are also a small number of 20 minute one-to-one sessions with the editor available.This may be useful if you have an idea for a story but would like to some advice on how best to pitch it. The editor can give you a steer and encouragement on the best angles for turning your research and expertise into articles. Please register your interest on the link below and we will be in contact with you. These are available on a strict first come, first served basis. To find out more about The Conversation, please visit www.ox.ac.uk/research/support-researchers/using-research-engage/conversation.

Booking Required

Audience: Members of the University only

Organisers: Janice Young

Wed 23 Oct 2019 from 14:00 to 17:00

DPAG Guest Speakers

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Fourth Annual Oxosome Meeting

Dr Stefan Balint, Dr Sascha Raschke, Dr Shih-Jung Fan, Dr Naveed Akbar, Dr Cheng Jiang, Lizzie Dellar, Dr Dimitri Aubert, Scott Bonner

Chairs: Dr Cláudia Mendes (Wilson and Goberdhan Labs) and Aashika Sekar (Wilson Lab) 2.05pm - Opening comments 2.15pm - Dr Stefan Balint (Dustin Lab, The Kennedy Institute of Rheumatology, University of Oxford) - Supramolecular attack particles- a non-vesicular ~100 nm particle mediating T cell... Read more

Chairs: Dr Cláudia Mendes (Wilson and Goberdhan Labs) and Aashika Sekar (Wilson Lab) 2.05pm - Opening comments 2.15pm - Dr Stefan Balint (Dustin Lab, The Kennedy Institute of Rheumatology, University of Oxford) - Supramolecular attack particles- a non-vesicular ~100 nm particle mediating T cell killing 2.30pm - Lizzie Dellar (Carter Lab, Dept. of Biological and Medical Sciences, Oxford Brookes University/ Baena Lopez lab, Sir Dunn School of Pathology, University of Oxford) - Unpacking the molecular principles facilitating RNA-loading in extracellular vesicles 2.45pm - Technical talk by Dr Sascha Raschke (Particle Metrix) - Phenotyping Extracellular Vesicles using Tetraspanins and fluorescence-NTA 3pm - Dr Shih-Jung Fan (Goberdhan Lab, Dept. of Physiology, Anatomy and Genetics, University of Oxford) - Glutamine Deprivation Regulates the Origin and Functions of Cancer Cell Exosomes 3.15pm - Refreshments Break in the Sherrington Foyer Chairs: Dr Genevive Melling (Carter Lab) and Dr Yvonne Couch (Buchan Lab) 4pm - Dr Naveed Akbar (Choudhury Lab, Radcliffe Dept. of Medicine, University of Oxford) - Extracellular Vesicles Mediate Immune Cell Mobilisation and Transcriptional Activation Following Acute Myocardial Infarction 4.15pm - Dr Cheng Jiang (Tofaris Lab, Nuffield Dept. of Clinical Neurosciences, University of Oxford) - Differential egress of α-synuclein and clusterin in serum neuronal exosomes precedes and predicts Parkinson’s disease 4.30pm - Technical Talk by Dr Dimitri Aubert (NanoFCM) - Nano-Flow Cytometry: A Platform for Comprehensive EV Analysis 4.45pm - Scott Bonner (Wood Lab, Dept. of Paediatrics, University of Oxford) - Characterisation of tumour-derived extracellular vesicle subpopulations and their role in cancer development 5pm - Closing comments Talk Summaries Supramolecular attack particles- a non-vesicular ~100 nm particle mediating T cell killing Dr Stefan Balint (Dustin Lab, The Kennedy Institute of Rheumatology, University of Oxford) T cells respond to cancer-associated antigens by releasing extracellular particles that combine determinants of antigen specificity and effector function. Extracellular vesicles produced by helper T cells bud directly from the centre of the immunological synapse upon engagement of the T cell receptor. We refer to these as synaptic ectosomes and have recently shown that they contain tetraspanins as well as CD40 ligand, a protein that is involved in B-T cell communication. In contrast, detailed examination of the released particles by cytotoxic T cells identified a new type of particles that we refer to as Supra-Molecular Attack Particles (SMAPs). SMAPs are non-membranous particles formed by a glycoprotein shell and contain a core of cytotoxic proteins, chemokines and cytokines. Thus, different subsets of T cells release distinct particles which could be a powerful tool for cancer immunotherapies. Unpacking the molecular principles facilitating RNA-loading in extracellular vesicles Lizzie Dellar (Carter Lab, Dept. of Biological and Medical Sciences, Oxford Brookes University/ Baena Lopez lab, Sir Dunn School of Pathology, University of Oxford) Our work makes use of Drosophila as a model system to understand the basic biological properties that facilitate the packing of RNA cargo into EVs. We have first characterised the RNA content of Drosophila S2R+-cell-derived EVs from both control and oxidative stress conditions. We then developed a bioinformatic pipeline for identification of sequence motifs and secondary structures that are enriched in EV-loaded RNAs. Using this approach, our analysis has identified several emerging properties of EV-loaded and cell-retained RNAs, findings which previous literature indicate may be evolutionary conserved. Our comparative analysis has also uncovered a subset of genes that are enriched in EVs under oxidative stress. Currently, we are validating our findings using an in vivo Cre-LoxP-based reporter system in Drosophila. Phenotyping Extracellular Vesicles using Tetraspanins and fluorescence-NTA Dr Sascha Raschke (Particle Metrix) In addition to determining the size and concentration of extracellular vesicles (EVs), phenotyping of these particles is another important factor in EV research. With our ZetaView® QUATT, we demonstrate a 4-laser NTA instrument that uses fluorescence- (f) NTA to quantitate EVs and determine ratios in a sample of different EVs by using different surface markers. For example, CD9-, CD81- and CD63-positive EVs can be distinguished by using fluorescence-labelled antibodies in 3 of the 4 fluorescence channels. The fourth fluorescence channel was used for the membrane dye CMDR to verify the presence of membranous particles. With the ZetaView® QUATT, it is possible for the first time to quantify from a sample of diverse extracellular vesicles those EVs by surface markers that are of particular interest. Glutamine Deprivation Regulates the Origin and Functions of Cancer Cell Exosomes Dr Shih-Jung Fan (Goberdhan Lab, Dept. of Physiology, Anatomy and Genetics, University of Oxford) Exosomes are generally thought to be made in late endosomal multivesicular bodies. We show that exosomes carrying unique cargos including Rab11a, are also made in recycling endosomes. Depletion of glutamine, a key metabolic nutrient, or suppression of nutrient-regulated mTORC1 signalling in cancer cells increases secretion of Rab11a-exosomes and other extracellular vesicle subtypes. These vesicles promote tumour cell turnover and blood vessel growth in xenograft mouse models. Antibodies against Amphiregulin (EGFR ligand) compromise their growth-promoting activity. We hypothesise that release of these stress-induced vesicles changes growth factor signalling in different regions of the tumour and thereby promotes tumour adaptation. Extracellular Vesicles Mediate Immune Cell Mobilisation and Transcriptional Activation Following Acute Myocardial Infarction Dr Naveed Akbar (Choudhury Lab, Radcliffe Dept. of Medicine, University of Oxford) Neutrophils and monocytes are rapidly mobilised from reserve such as the spleen to peripheral blood following acute myocardial infarction. Mobilised cells undergo transcriptional activation en route to the injured myocardium and mediate further injury. We have shown that endothelial cell derived extracellular vesicles mobilise neutrophils and monocytes from the spleen and induce their transcriptional programming. Targeting neutrophil and monocyte transcriptomes in AMI with bioengineered EVs may salvage the myocardium in the immediate hours after injury. Nano-Flow Cytometry: A Platform for Comprehensive EV Analysis Dr Dimitri Aubert (NanoFCM) Though of great importance, sizing, counting and molecular profiling of individual extracellular vesicles (EVs) are technically challenging due to their nanoscale particle size, minute quantity of analytes, and overall heterogeneity. NanoFCM has developed Nano-Flow Cytometry (nFCM), a technology that allows light scattering and fluorescence detection of single EVs down to 40 nm. nFCM-based approach for quantitative multiparameter analysis of EVs, which is highly desirable to decipher their biological functions and promote the development of EV-based liquid biopsy and therapeutics. Differential egress of α-synuclein and clusterin in serum neuronal exosomes precedes and predicts Parkinson’s disease Dr Cheng Jiang (Tofaris group, Nuffield Department of Clinical Neurosciences, University of Oxford) Among 638 individuals tested cross-sectionally, neuron-derived exosomal α-synuclein was elevated by 2-fold in prodromal and clinical Parkinson’s disease but not in unrelated neurodegenerative diseases. In longitudinal serum samples, exosomal α-synuclein was stably increased with PD progression and consistent when tested across cohorts. Mean exosomal clusterin was increased in other proteinopathies but not α-synucleinopathies. Combined exosomal α-synuclein and clusterin measurement improved the predictive value of a primary α-synucleinopathy versus an alternative proteinopathy (AUC =0.98). Characterisation of tumour-derived extracellular vesicle subpopulations and their role in cancer development Scott Bonner (Wood Lab, Department of Pediatrics, University of Oxford) Extracellular vesicles (EVs) represent a heterogeneous population of membrane enclosed vesicles that function as mediators of intercellular communication. In the context of tumour-derived EVs as mediators of cancer development and progression, this heterogeneity could cause certain EV subpopulations to have unique roles in the intricate biological processes underlying cancer biology. For example, we have observed that only a certain subpopulation of EVs supports ovarian cancer cell adhesion to matrixes in a CD29-dependent manner, suggesting involvement of this subpopulation in tumour metastasis. Following up on these observations, in this study we further characterised EV subpopulations from ovarian cancer cells both on a single vesicle and proteomics level. We analysed biomarker colocalization using the Nanoview ExoView R100, peptide mass fingerprints via MALDI-TOF mass spectrometry and assessed integrin beta 1 (CD29) expression on EVs using super-resolution microscopy techniques. The data gained highlights the relevance of EV heterogeneity, with particular regard to the role of EVs in the progression and development of cancer.

Audience: Members of the University only

Organisers: Dave Carter

Followed by a wine reception in the Sherrington Foyer

Thu 24 Oct 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, TDI seminar room, lower ground floor, Headington OX3 7FZ

Rho GTPase signalling in cancer migration and invasion

Professor Anne Ridley

Audience: Members of the University only

Organisers: Alexandra Ward

Thu 24 Oct 2019 from 13:00 to 14:00

Population Health Seminars

61 Banbury Road, School of Anthropology, 61 Banbury Road OX2 6PF

Unit for Biocultural Variation and Obesity (UVBO) Seminar - Nutrient timing and human health

James Betts

Audience: Members of the University only

Organisers: Graham Bagley

Thu 24 Oct 2019 from 13:00 to 14:00

Medical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Respiratory / Acute General Medicine Firm C

Prof Ian Pavord, Dr Simon Couillard De L'Espinay, Dr Praveen Weeratunga, Dr Giles Bond-Smith, Dr Judy Martin

Respiratory: "Aspirin-induced asthma: mechanisms and treatment options", Prof Ian Pavord and Dr Simon Couillard De L'Espinay -- Acute General Medicine Firm C: "A common surgical problem on the medical take", Dr Praveen Weeratunga, Dr Giles Bond-Smith and Dr Judy Martin -- Chair: Prof Hugh Watkins

Respiratory: "Aspirin-induced asthma: mechanisms and treatment options", Prof Ian Pavord and Dr Simon Couillard De L'Espinay -- Acute General Medicine Firm C: "A common surgical problem on the medical take", Dr Praveen Weeratunga, Dr Giles Bond-Smith and Dr Judy Martin -- Chair: Prof Hugh Watkins

Audience: Members of the University and NHS clinical staff.

Thu 24 Oct 2019 from 13:30 to 14:30

Metabolism & Endocrinology Theme Guest Speakers (DPAG)

Sherrington Building, Sherrington Room (2nd Floor), off Parks Road OX1 3PT

From breastfeeding to independent feeding: the origins of homeostatic sensing

Marcelo de Oliveira Dietrich, M.D., Ph.D.

All mammals transition from breastfeeding to independent feeding during the lactation period. In humans and other mammals, this critical transition is important for later in life metabolic control and, consequently, for the development of obesity and diabetes. Here, Dr. Dietrich will discuss the... Read more

All mammals transition from breastfeeding to independent feeding during the lactation period. In humans and other mammals, this critical transition is important for later in life metabolic control and, consequently, for the development of obesity and diabetes. Here, Dr. Dietrich will discuss the work of his lab studying the function of hypothalamic neurons involved in homeostatic control during the transition from breastfeeding to independent feeding. His work illuminates novel properties of hypothalamic neurons in early life, suggesting mechanisms by which early life events shape homeostatic regulation throughout the individual’s lifespan.

Audience: Members of the University only

Organisers: Professor David Paterson

Fri 25 Oct 2019 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Organ preservation research in Oxford – an update

Mr Simon Knight, Mr James Hunter

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 25 Oct 2019 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Interactions between hypoxia and immunity – a chance discovery leading to opportunities for collaboration’

Professor Chris Pugh

Audience: Members of the University only

Organisers: Anne Farmer

Fri 25 Oct 2019 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

GL Brown Prize Lecture: Tackling the pathophysiology of motor neuron disease (MND): a translational neuroscience approach

Professor Dame Pamela Shaw

Motor neuron disease (MND) is one of the 3 commonest adult onset neurodegenerative disorders with a prevalence of approximately 6-8/100,000. The clinical features are caused by injury and cell death usually of both upper motor neurons in the brain and lower motor neuron groups in the brainstem and... Read more

Motor neuron disease (MND) is one of the 3 commonest adult onset neurodegenerative disorders with a prevalence of approximately 6-8/100,000. The clinical features are caused by injury and cell death usually of both upper motor neurons in the brain and lower motor neuron groups in the brainstem and spinal cord. Death in most patients results from neuromuscular respiratory failure. The rapidity of disease progression in many cases causes MND to be regarded as one of the most feared diseases in medicine. The heterogeneity and complexity of MND has poses a challenge for neuroprotective therapy development. This lecture will cover 5 areas of topical interest in relation to this neurodegenerative condition. 1. An introduction to the intricate and fascinating properties of the human motor system and what goes wrong to cause the clinical and pathological features of MND. 2. A discussion on current thinking in relation to disease pathogenesis ie why motor neurons die. New generation genetic sequencing techologies have enable rapid progress in unravelling genetic causes of motor neuron degeneration. Insights into disease pathophysiology arising from study of experimental models of MND will be discussed, including our ability now to reprogamme skin cells do create a human model of MND in the laboratory. Pathophysiological changes at cellular and in vivo in rodent models and human patients will be highlighted. 3. New scientific approaches that can be applied to the problem of MND will be considered. These include laser capture microdissection to isolate motor neurons and study their properties in great detail. In addition, the repertoire of cellular gene and protein expression of motor neurons in health and disease states, can be studied using transcriptomic and proteomic approaches respectively. The other new approach is to investigate the contribution of the “neighbourhood” cells in the nervous system eg astrocytes in the initiation and/or propagation of motor neuron injury. 4. The next section of this presentation will consider whether we are winning in terms of the translation of recent scientific research into benefits for patients who develop MND. Progress in neuroprotective therapy development, including gene therapy approaches and in improving life expectancy and quality of life by advances in symptom management will be considered. 5. The final section will consider how the relationships between scientific researchers and patients, the public and society are changing and the positive value emerging from this two-way relationship. Two illustrative examples include the creation of SITraN and the development of a new, recently marketed device for neuromuscular disorders.

Audience: Members of the University only

Organisers: Professor David Paterson

Mon 28 Oct 2019 from 12:00 to 13:00

OPDC Seminar Series (DPAG)

Sherrington Library, off Parks Road OX1 3PT

The magic in the web of it: How a rare disorder is helping to untangle the mysteries of Parkinson’s disease

Dr Ellen Sidransky

Dr. Sidransky, chief of the Molecular Neurogenetics Section, is a pediatrician and clinical geneticist in the Medical Genetics Branch of the National Human Genome Research Institute at the National Institutes of Health in Bethesda, Maryland. Dr. Sidransky has been a tenured investigator at NIH and... Read more

Dr. Sidransky, chief of the Molecular Neurogenetics Section, is a pediatrician and clinical geneticist in the Medical Genetics Branch of the National Human Genome Research Institute at the National Institutes of Health in Bethesda, Maryland. Dr. Sidransky has been a tenured investigator at NIH and a section chief since 2000. Her research includes both clinical and basic research aspects of Gaucher disease and Parkinson's disease, and her group first identified glucocerebrosidase as a risk factor for parkinsonism. She has spearheaded two large international collaborative studies regarding the genetics of Parkinson's disease and dementia with Lewy bodies. Her current work also focuses on understanding the complexity encountered in "simple" Mendelian disorders, the association between Gaucher disease and parkinsonism and the development of small molecule chaperones as therapy for Gaucher disease and potentially parkinsonism. Dr. Sidransky directs two NIH clinical protocols, one evaluating patients with lysososmal storage disorders and the second prospectively studying patients and relatives with parkinsonism who carry mutations in GBA.

Audience: Members of the University only

Organisers: Melanie Witt

Mon 28 Oct 2019 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7FY

Lymphoid stromal cells are essential components of macrophage niches

Dr Marc Bajénoff

Although the myeloid community recently made tremendous progress in understanding the origin and roles of tissue-resident Mϕ, a comprehensive understanding of the mechanisms supporting their homeostasis is lacking. . The concept of the Mϕ niche postulates that Mϕ homeostasis is locally... Read more

Although the myeloid community recently made tremendous progress in understanding the origin and roles of tissue-resident Mϕ, a comprehensive understanding of the mechanisms supporting their homeostasis is lacking. . The concept of the Mϕ niche postulates that Mϕ homeostasis is locally regulated by “niches” that provide both an anchoring and nurturing scaffold to Mϕ. Here, I will present recent data suggesting that lymphoid stromal cells represent essential components of the Mϕ niche in lymphoid organs.

Audience: Public

Organisers: Jennifer Pope

Mon 28 Oct 2019 from 14:00 to 15:00

Population Health Seminars

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

NPEU Seminar - Understanding Challenges in Newborn Care to Improve Patient Outcomes

Associate Professor Charle Roehr

Audience: Members of the University only

Organisers: Graham Bagley

Mon 28 Oct 2019 from 15:00 to 16:00

BDI seminars

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

Phenome@BDI Seminar - Additional dimensions in mass spectrometry: velocity-map imaging

Professor Claire Vallance

molecular fragments. In biological applications, mass spectrometry is used to characterise a wide variety of biomolecules, including sugars, proteins, and oligonucleotides; for example, sequencing of proteins and peptides and identification of post-translational modifications. While methods such... Read more

molecular fragments. In biological applications, mass spectrometry is used to characterise a wide variety of biomolecules, including sugars, proteins, and oligonucleotides; for example, sequencing of proteins and peptides and identification of post-translational modifications. While methods such as ion mobility spectrometry and H/D exchange techniques have been implemented in order to obtain additional structural information from mass spectra, none yield direct information on atomic connectivity within the structure. We have recently developed a new technique known as Coulomb-explosion covariance-map imaging, a variation on the velocity-map imaging method employed widely within the field of chemical reaction dynamics. While so far only applied to small molecules, our new approach provides direct structural information, and even promises the ability to follow structural change on the femtosecond timescale over which chemical change occurs.

Audience: Members of the University only

Tue 29 Oct 2019 from 13:00 to 14:00

Population Health Seminars

Big Data Institute, Seminar rooms, Old Road Campus OX3 7LF

Richard Doll Seminar - Prostate cancer screening and treatment: what is the trial evidence and linked epidemiology

Professor Athene Lane

Audience: Members of the University only

Organisers: Graham Bagley

Tue 29 Oct 2019 from 14:00 to 15:00

Strubi seminars

Wellcome Trust Centre for Human Genetics, Meeting rooms A & B, Headington OX3 7BN

"Cryo-EM structure of a poly(A) RNP bound to the Pan2-Pan3 deadenylase"

Dr Ingmar B Schäfer

The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail. This poly(A) RNP protects mRNAs from premature degradation but also stimulates the Pan2-Pan3 deadenylase complex to catalyze the first step of... Read more

The stability of eukaryotic mRNAs is dependent on a ribonucleoprotein (RNP) complex of poly(A)-binding proteins (PABPC1/Pab1) organized on the poly(A) tail. This poly(A) RNP protects mRNAs from premature degradation but also stimulates the Pan2-Pan3 deadenylase complex to catalyze the first step of poly(A) tail shortening. We reconstituted this process in vitro using recombinant proteins and show that Pan2-Pan3 associates with and degrades poly(A) RNPs containing two or more Pab1 molecules. The cryo-EM structure of Pan2-Pan3 in complex with a poly(A) RNP composed of 90 adenosines and three Pab1 protomers shows how the oligomerization interfaces of Pab1 are recognized by conserved features of the deadenylase and thread the poly(A) RNA substrate into the nuclease active site. The structure reveals the basis for the periodic repeating architecture at the 3' end of cytoplasmic mRNAs. This illustrates mechanistically how RNA-bound Pab1 oligomers act as rulers for poly(A) tail length over the mRNAs’ lifetime.

Audience: Members of the University only

Organisers: Agata Krupa

Wed 30 Oct 2019 from 12:00 to 13:00

Peter Medawar Building Seminars

Zoology Research and Administration Centre, Seminar room

Understanding rotavirus dynamics in response to vaccination

Virgina Pitzer

The recent introduction of rotavirus vaccines into the national immunization schedules of the United States and other countries has led to substantial reductions in the incidence of severe diarrhea in children. However, there is concern over whether indirect protection evident in high-income... Read more

The recent introduction of rotavirus vaccines into the national immunization schedules of the United States and other countries has led to substantial reductions in the incidence of severe diarrhea in children. However, there is concern over whether indirect protection evident in high-income countries in the short term will extend to low-income countries and to the long term, and whether the selective pressures imposed by vaccines will lead to the emergence of non-vaccine-type strains. Using data-driven models for the transmission dynamics of rotavirus, we generate predictions about rotavirus dynamics in response to vaccination by relating individual-level protection offered by vaccines to population-level effects. I will discuss how models were able to predict the post-vaccination emergence of a biennial pattern of epidemics in the US, why rotavirus genotypes tend to cycle, and possible explanations for the lower vaccine effectiveness observed in countries such as Malawi.

Audience: Members of the University only

Organisers: Suki Kenth

Wed 30 Oct 2019 from 12:30 to 13:30

WHG Lunchtime Lab Talks

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

Bashford-Rogers & Todd Lunchtime Lab Talks

Ricardo Ferreira, Bo Sun

Bashford-Rogers Group Speaker: Bo Sun Title: ‘Dissecting pathogenic antibody responses in autoimmune encephalitis’ Todd Group Speaker: Ricardo Ferreira Title: ‘Dissecting pathogenic antibody responses in autoimmune encephalitis Simultaneous mRNA and protein quantification at the single-cell level delineates trajectories of CD4+ T-cell differentiation’

Bashford-Rogers Group Speaker: Bo Sun Title: ‘Dissecting pathogenic antibody responses in autoimmune encephalitis’ Todd Group Speaker: Ricardo Ferreira Title: ‘Dissecting pathogenic antibody responses in autoimmune encephalitis Simultaneous mRNA and protein quantification at the single-cell level delineates trajectories of CD4+ T-cell differentiation’

Audience: Members of the University only

Organisers: Isabel Schmidt

Thu 31 Oct 2019 from 11:30 to 12:30

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

VIVA - How do Gata1 and cohesin gene mutations contribute to the development of myeloid leukaemia?

Catherine Garnett

Audience: Members of the University only

Organisers: Emma Butterfield

Thu 31 Oct 2019 from 12:00 to 13:00

WHG Seminars

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

Whole-genome sequencing of rare disease patients in a national healthcare system

Ernest Turro

In my talk, I will describe three recently completed research projects I have led or co-led. Firstly, I will describe a genetic association method for rare Mendelian diseases called BeviMed. Secondly, I will present the results of the analyses of whole-genome sequencing (WGS) data for 13,037... Read more

In my talk, I will describe three recently completed research projects I have led or co-led. Firstly, I will describe a genetic association method for rare Mendelian diseases called BeviMed. Secondly, I will present the results of the analyses of whole-genome sequencing (WGS) data for 13,037 participants in an NIHR-funded study, of whom 9,802 had a rare disease. Briefly, we provided a genetic diagnosis to 1,138 patients, we identified 99 BeviMed associations between genes and rare diseases, we showed that rare alleles can explain the presence of some UK Biobank participants in the tails of a quantitative red blood cell trait, and we reported 4 novel non-coding variants which cause disease through the disruption of transcription. Finally, I will describe our analysis of mitochondrial DNA sequences, generated as a by-product of WGS, suggesting that mitochondrial DNA is under selective forces exerted by the nuclear genome.

Audience: Members of the University only

Organisers: Isabel Schmidt

Thu 31 Oct 2019 from 13:00 to 14:00

Medical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Renal / Gastroenterology

Dr Timothy Ambrose, Dr Isabella Bertoni, Prof Ian Roberts

Renal: "An yttriumsting case", Dr Isabella Bertoni and Prof Ian Roberts -- Gastroenterology: "Intestinal Transplantation – Quality and Quantity?", Dr Timothy Ambrose. Chair: Prof Richard Cornall

Renal: "An yttriumsting case", Dr Isabella Bertoni and Prof Ian Roberts -- Gastroenterology: "Intestinal Transplantation – Quality and Quantity?", Dr Timothy Ambrose. Chair: Prof Richard Cornall

Audience: Members of the University and NHS clinical staff.