Other Seminars

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Mon 1 Oct 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

Transcriptomics reveal the immune response in tuberculosis:Type I IFN response in tuberculosis: foe & occasionally friend

Prof Anne O'Garra

Tuberculosis remains a major cause of morbidity and mortality worldwide, but despite its clinical significance, there are still major gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection. Type I interferons (IFN) regulate a broad family... Read more

Tuberculosis remains a major cause of morbidity and mortality worldwide, but despite its clinical significance, there are still major gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection. Type I interferons (IFN) regulate a broad family of genes that either stimulate or inhibit immune function, having both host-protective and detrimental effects, and exhibit well-characterized antiviral activity. Using blood transcriptomic analyses, we revealed that the tuberculosis signature was dominated by an interferon (IFN)-inducible gene profile, consisting of both IFN- and Type I IFNαβ signaling, and suggested a hitherto under-appreciated role of Type I IFNαβ signalling in human tuberculosis pathogenesis. Since then, additional studies in human tuberculosis and experimental mouse models of M. tuberculosis infection support the concept that high levels of type I IFN promote both bacterial expansion and disease pathogenesis. More recently, however, in studies in a different setting we suggest a putative protective role for type I IFN. I will discuss the mechanistic and contextual factors that determine the detrimental versus beneficial outcomes of type I IFN induction during M. tuberculosis infection, from human disease to experimental mouse models of tuberculosis. ---- O’Garra pioneered studies demonstrating the role of cytokines in immune regulation. Her work has defined mechanisms whereby key cytokines are induced by microbial products acting on innate cells to direct the development of protective immune responses to pathogens, and the regulation of such responses to prevent host damage by pathways which can also contribute to chronic infection such as in tuberculosis. The development of an appropriate immune response to a specific pathogen is essential for its eradication. However, an uncontrolled immune response can result in collateral damage to the host. O’Garra pioneered studies revealing the role of cytokines in directing the immune response required to eradicate intracellular pathogens and identified key mechanisms whereby cytokines regulate this process. O’Garra first showed that the cytokine interleukin-10 (IL-10) inhibits macrophage and dendritic cell function, including the production of cytokines and their antigen presenting capacity which are critical for host protection and initiation of T cell responses. Following these landmark studies on IL-10, O’Garra went on to demonstrate that microbial products induce the production of the cytokines IL-12 and IL-18/IGIF by macrophages and dendritic cells which direct the development and maintenance of T helper 1 (Th1) responses critical for protection against intracellular pathogens. O’Garra’s findings that IL-10 inhibits IL-12 driven Th1 responses by direct action on macrophages and dendritic cells have stood the test of time, and underpin the mechanisms underlying many chronic infections. In keeping with this, in a landmark study published in 2010, O’Garra demonstrated a transcriptional signature of active tuberculosis dominated by type I interferon inducible genes, which she has shown contributes to chronic disease by induction of the suppressive cytokine IL-10 and inhibition of IL-12. O’Garra’s discoveries provide a unified framework explaining how cytokine responses determine the course of infection, with major implications for the development of new vaccines and strategies for intervention in infectious and inflammatory diseases.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Mon 1 Oct 2018 from 12:00 to 13:00

BDI seminars

Big Data Institute, Seminar Room 0, Old Road Campus OX3 7LF

Mon 1 Oct 2018 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Finally: empty class I molecules

Prof Sebastian Springer

Empty MHC class I molecules are known to exist, but they are difficult to investigate. I will explain what we have learnt – using a novel antibody micropatterning two-hybrid assay - about the ability of free heavy chains to form in cis clusters on the cell surface. In the second part, I will... Read more

Empty MHC class I molecules are known to exist, but they are difficult to investigate. I will explain what we have learnt – using a novel antibody micropatterning two-hybrid assay - about the ability of free heavy chains to form in cis clusters on the cell surface. In the second part, I will focus on our recent development of stable recombinant class I molecules . They can be used to make empty tetramers that load within seconds with any added peptide, with interesting applications in tumor epitope screening.

Audience: Members of the University only

Organisers: Anne Farmer

Mon 1 Oct 2018 from 14:00 to 15:00

BDI seminars

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

Phenome@BDI Seminar: Physical activity & time-series analysis

Dr Aiden Doherty, Matthew Willetts

Audience: Members of the University only

Organisers: Carol Mulligan-John

Tue 2 Oct 2018 from 09:00 to 17:00

OPDC Seminar Series (DPAG)

Medical Sciences Teaching Centre, off South Parks Road OX1 3PL

OPDC Parkinson's Research Day

Dr Natalie Connor-Robson, Dr Paul Dodson, Dr Jimena Monzon Sandoval, Dr Dayne Beccano-Kelly, Dr Brent Ryan, Dr Thomas Barber, Dr Christine Lo, Dr Ludovica Griffanti, Dr Teresa Delgado-Goni, Dr Paul Reading, Dr Thomas Gasser

The OPDC Research Day is a one-day event will include research talks by national and international keynote speakers and Oxford researchers on a range of Parkinson’s work including clinical studies, imaging, genetics, proteomics, neuronal cell culture and animal models. Poster Abstract Submission... Read more

The OPDC Research Day is a one-day event will include research talks by national and international keynote speakers and Oxford researchers on a range of Parkinson’s work including clinical studies, imaging, genetics, proteomics, neuronal cell culture and animal models. Poster Abstract Submission closes Friday September 14th 2018 If you have any further queries please contact opdc.administrator@dpag.ox.ac.uk.

Booking Required

Audience: Members of the University only

Organisers: Melanie Witt

Registration for the 2018 OPDC research day is free and includes refreshments, lunch and reception. Please complete the registration form below to join us at this exciting event. Registration closes on September 26th 2018

Wed 3 Oct 2018 from 11:00 to 12:30

Ethox Centre and Wellcome Centre for Ethics and Humanities

Big Data Institute, Seminar Room 1, Old Road Campus OX3 7LF

End of Life care in ICUs in Ain Shams University Hospitals, Cairo, Egypt

Sonya Azab

Audience: Members of the University only

Wed 3 Oct 2018 from 12:30 to 13:30

WHG Lunchtime Lab Talks

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

Davies and Gloyn Lunchtime Lab Talks

Dr Samy AlGhadban, Dr Phalguni Rath, Dr Nicole Krentz, Dr Jason Torres

Davies Group Speaker: Dr Samy AlGhadban Title: ‘Improved mouse mutagenesis by electroporation’ Speaker: Dr Phalguni Rath Title: ‘A platform for rapid modification of endogenous gene transcription by CRISPR/CAS9’ Gloyn Group Speaker: Dr Nicole Krentz Title: ‘Identifying mechanisms for T2D... Read more

Davies Group Speaker: Dr Samy AlGhadban Title: ‘Improved mouse mutagenesis by electroporation’ Speaker: Dr Phalguni Rath Title: ‘A platform for rapid modification of endogenous gene transcription by CRISPR/CAS9’ Gloyn Group Speaker: Dr Nicole Krentz Title: ‘Identifying mechanisms for T2D GWAS variants in hiPSCs’ Speaker: Dr Jason Torres Title: ‘Tissue-level classification of loci associated with type 2 diabetes’

Audience: Members of the University only

Organisers: Isabel Schmidt

Thu 4 Oct 2018 from 10:30 to 11:30

Nuffield Department of Primary Care Health Sciences - Department research seminars

St Luke's Chapel, Woodstock Road OX2 6GG

Open Access and Act on Acceptance

Juliet Ralph, Nia Roberts

Covering: - Why open access, why deposit? - Depositing author accepted manuscript within 3 months of date of acceptance - Open access payments, green route and were to seek advice on payments

Covering: - Why open access, why deposit? - Depositing author accepted manuscript within 3 months of date of acceptance - Open access payments, green route and were to seek advice on payments

Audience: Members of the University only

Organisers: Lucy Curtin

Thu 4 Oct 2018 from 13:00 to 14:00

Medical Grand Rounds

Cardiology / Neurology

Dr Sanjay Manohar, Dr Andrew Lucking

Cardiology: "The role of high sensitivity troponin assay in the assessment of acute cardiac-sounding chest pain", Dr Andrew Lucking -- Neurology: "Slow and unsteady" Dr Sanjay Manohar -- Chair: Prof Chris Conlon

Cardiology: "The role of high sensitivity troponin assay in the assessment of acute cardiac-sounding chest pain", Dr Andrew Lucking -- Neurology: "Slow and unsteady" Dr Sanjay Manohar -- Chair: Prof Chris Conlon

Audience: Members of the University and NHS clinical staff.

Thu 4 Oct 2018 from 16:30 to 18:30

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, George Pickering Education Centre Level 3 Academic Centre, Room 4A, Headington OX3 9DU

Defects in Cytokine Signalling as Cause for IBD and Immunodeficiences

Dr Dominik Aschenbrenner, Dr Hebe Chen

Audience: Members of the University only

Organisers: Professor Holm Uhlig

Fri 5 Oct 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

In depth analysis of poorly enhancing but potently neutralizing antibody against dengue virus

Wanwisa Dejnirattisai

Audience: Members of the University only

Organisers: Anne Farmer

Mon 8 Oct 2018 from 12:00 to 13:00

CNCB Seminar Series

Oxford Martin School, Lecture Theatre , 34 Broad Street OX1 3BD

Operating Principles of a Learning Network in Electric Fish

Larry Abbott

The electrosensory lobe (ELL) in mormyrid electric fish is a cerebellar-like structure (also mushroom-body like) that cancels the sensory effects of self-generated electric fields, allowing prey to be detected. Like the cerebellum, the ELL involves two stages of processing, analogous to the... Read more

The electrosensory lobe (ELL) in mormyrid electric fish is a cerebellar-like structure (also mushroom-body like) that cancels the sensory effects of self-generated electric fields, allowing prey to be detected. Like the cerebellum, the ELL involves two stages of processing, analogous to the Purkinje cells and output cells of the deep cerebellar nuclei. Through the work of Curtis Bell and others, a model was previously developed to describe the output stage of the ELL, but the role of the Purkinje-cell analogs, the medium ganglion (MG) cells, in the circuit had remained mysterious. I will present a complete circuit description of the ELL, developed in collaboration with Nate Sawtell and Salomon Muller, the reveals a novel role for the MG cells. The resulting model of ELL function relies on a principle of circuit organization based on the learning rather than the response properties of neurons that we have verified in the anatomy of the ELL.

Audience: Members of the University only

Organisers: Fiona Woods

Mon 8 Oct 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

On the origin of blood and lymphatic vessels

Dr Oliver Stone

The establishment of distinct cell fates is a prerequisite for the development of complex multicellular organisms. A striking paradigm for this diversification can be observed in the vascular endothelium, which differentiates to form arterial, venous, lymphatic and organ specific networks. Current... Read more

The establishment of distinct cell fates is a prerequisite for the development of complex multicellular organisms. A striking paradigm for this diversification can be observed in the vascular endothelium, which differentiates to form arterial, venous, lymphatic and organ specific networks. Current dogma suggests that following specification from mesoderm, environmental cues define the molecular and functional characteristics of endothelial cells in different vascular beds. I will present evidence to challenge this view, showing that lymphatic endothelial fate is imprinted as cells transition through a subset of mesoderm, a finding with broad implications for our understanding of cell lineage commitment. ---- I am currently a British Heart Foundation Transition Research Fellow in the Department of Physiology, Anatomy and Genetics at the University of Oxford. My research harnesses zebrafish and rodent models to understand the cellular and molecular mechanisms controlling cardiovascular development and disease. I obtained my PhD from the University of Bristol and then trained in the laboratory of Didier Stainier at the Universtiy of California, San Francisco and Max Planck Institute for Heart and Lung Research. My work has identified the earliest known transcriptional regulator of endothelial cell differentiation (Reischauer*, Stone* et al., Nature, 2016), established a link between metabolic dysfunction and innate immune signalling in endothelial cells (Stone et al., Nature Comms, In Press), and is currently focused on defining the cellular and molecular events that determine endothelial cell fate and heterogeneity.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Mon 8 Oct 2018 from 12:00 to 13:00

BDI seminars

Big Data Institute, Seminar Room 0 , Old Road Campus OX3 7LF

Mon 8 Oct 2018 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

RAS, from cancer to development (and back)

Prof Hélène Cavé

Audience: Members of the University only

Organisers: Liz Cloke

Mon 8 Oct 2018 from 17:00 to 18:00

Burdon Sanderson Cardiac Science Centre Lecture Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Inherited arrhythmias: from bench to bedside and back

Professor Silvia G. Priori

Dr Priori, is Professor of Cardiology in the Department of Molecular Medicine at the University of Pavia. She is a world leader in the field of inherited arrhythmias and cardiomyopathies. She combines clinical work with basic research and, among other important achievements, she discovered the... Read more

Dr Priori, is Professor of Cardiology in the Department of Molecular Medicine at the University of Pavia. She is a world leader in the field of inherited arrhythmias and cardiomyopathies. She combines clinical work with basic research and, among other important achievements, she discovered the gene that causes the autosomal dominant form of Catecholaminergic Polymorphic Ventricular Tachycardia and developed the first animal model that allowed the understanding of the mechanisms for arrhythmogenesis. Based on this discovery she demonstrated the antiarrhythmic activity of Inhibition of CAMKII that is now advancing toward the development of a drug for humans and she demonstrated in the mouse model of the disease the efficacy of an RNA interference strategy to correct the consequences of the molecular defect (gene therapy).

Audience: Members of the University only

Tue 9 Oct 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Richard Doll Seminar: Diet, nutrition, physical activity and cancer: the current state of the evidence (and how to use it)

Emeritus Professor Hilary J Powers

Julian Peto FMedSci read maths at Oxford (1964-67) followed by an MSc in statistics at Imperial College. He worked as a statistician at Edinburgh University, then in London at the Institute of Psychiatry and the MRC TB Unit. He returned to Oxford in 1974 to join the ICRF Cancer Epidemiology and... Read more

Julian Peto FMedSci read maths at Oxford (1964-67) followed by an MSc in statistics at Imperial College. He worked as a statistician at Edinburgh University, then in London at the Institute of Psychiatry and the MRC TB Unit. He returned to Oxford in 1974 to join the ICRF Cancer Epidemiology and Clinical Trials Unit, part of Richard Doll’s burgeoning empire. From 1983 to 2004 he was Cancer Research UK Professor of Epidemiology and head of the Section of Epidemiology at the Institute of Cancer Research where, together with Bruce Ponder and Mike Stratton, he initiated the work that led to the discovery of BRCA2. His work has included clinical trials on various cancers and more recently the VIDAL (Vitamin D and Longevity) trial, and many epidemiological studies. His main current interests are the natural history of human papillomavirus infection and cervical cancer, particularly in relation to screening, and the hazards of asbestos, which were underestimated when he began studying it in 1975 and are now exaggerated. His Chair was transferred to the London School of Hygiene and Tropical Medicine in 2004.

Audience: Members of the University only

Wed 10 Oct 2018 from 12:00 to 13:00

Peter Medawar Building Seminars

Medawar Building, Level 30 Seminar Room, off South Parks Road OX1 3SY

Sheep in Wolves' Clothing: Insect-specific viruses of mosquitoes exploited as novel platforms for diagnostics and vaccines

Prof Roy Hall

Over the last decade our group have discovered several insect-specific flaviviruses (ISFs) in mosquitoes from different regions of Australia. These viruses do not replicate in vertebrate cells but grow to high titre in mosquito cultures. Genome sequence analyses of these viruses reveal we have... Read more

Over the last decade our group have discovered several insect-specific flaviviruses (ISFs) in mosquitoes from different regions of Australia. These viruses do not replicate in vertebrate cells but grow to high titre in mosquito cultures. Genome sequence analyses of these viruses reveal we have discovered many new species of ISFs representing two distinct genetic lineages. Construction of infectious DNAs and chimeric viruses has allowed us to identify stages at pre- and post-cell entry where ISF infection and replication is blocked in vertebrate cells. We have also generated a series of chimeric viruses expressing the structural genes (prM-E) from pathogenic flaviviruses, including West Nile, Zika and dengue viruses, spliced into the genetic backbone of two different ISF species. These chimeras exhibit the insect-specific phenotype of their parental ISFs, growing efficiently in mosquito cells but not in vertebrate cultures but are structurally indistinguishable from virions of the pathogenic parental viruses. These chimeric viruses are proving to be excellent candidates for safe diagnostic antigens and vaccines for mosquito-borne flaviviral diseases.

Audience: Members of the scientific community

Organisers: Professor Sunetra Gupta

Please allow 5 minutes before the seminar to gain access to the building

Thu 11 Oct 2018 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

Coincidence detection tailors macrophage responses to inflammatory signals

Jelena Bezbradica Mirkovic

Audience: Members of the University only

Organisers: Christina Woodward

Thu 11 Oct 2018 from 12:00 to 13:30

Ethox Centre and Wellcome Centre for Ethics and Humanities

Richard Doll Building, Main Meeting Room, Old Road Campus OX3 7LF

Ethox and WEH Seminar - Authenticity and citizenship in people living with dementia in a care home

Julian Hughes

What is it to be "authentic" or true to yourself? What is it to be a "citizen"? Although these ideas are complicated, they are also straightforward aspects of our lives: we naturally try to be true to ourselves and we are naturally part of a community. But these things can also be difficult,... Read more

What is it to be "authentic" or true to yourself? What is it to be a "citizen"? Although these ideas are complicated, they are also straightforward aspects of our lives: we naturally try to be true to ourselves and we are naturally part of a community. But these things can also be difficult, especially when our very sense of self is under threat, which it can be for people living with dementia. If we find ourselves living in a care home, our authentic selves and our participation as citizens comes under even more threat. I shall talk about these issues and about a small study we have done looking at how an artist contributed to authenticity and citizenship in a care home in the North East of England.

Audience: Members of the University only

Thu 11 Oct 2018 from 13:00 to 14:00

Medical Grand Rounds

Haematology / Gastroenterology

Dr Jeremy Cobbold, Dr Omer Pervaiz

Haematology: "To DOac or to NOac? That is the Question", Dr Omer Pervaiz -- Gastroenterology: "NAFLD: Hiding in Plain Sight", Dr Jeremy Cobbold -- Chair: Prof Chris Conlon

Haematology: "To DOac or to NOac? That is the Question", Dr Omer Pervaiz -- Gastroenterology: "NAFLD: Hiding in Plain Sight", Dr Jeremy Cobbold -- Chair: Prof Chris Conlon

Audience: Members of the University and NHS clinical staff.

Thu 11 Oct 2018 from 14:00 to 15:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

UBVO Seminar: Chess, not chequers

Professor Harry Rutter

Audience: Members of the University only

Organisers: Graham Bagley

Fri 12 Oct 2018 from 08:00 to 09:00

Department of Oncology

Fri 12 Oct 2018 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Personalised External Aortic Root Support: the Oxford experience

Miss Renata Greco

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 12 Oct 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

“The weakness of the enemy makes our strength”: exploiting SAMHD1 mutations to kill cancer cells

Tamara Davenne

Audience: Members of the University only

Organisers: Anne Farmer

Fri 12 Oct 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Visual stimulus processing and spatial memory in the retrosplenial cortex

Professor Frank Sengpiel

The retrosplenial cortex (RSC) has been shown to be involved in a number of cognitive functions, in particular episodic memory and navigation, but relatively little is known about responses at the neuronal level. We have analysed activity in the RSC of awake mice to simple visual stimuli using... Read more

The retrosplenial cortex (RSC) has been shown to be involved in a number of cognitive functions, in particular episodic memory and navigation, but relatively little is known about responses at the neuronal level. We have analysed activity in the RSC of awake mice to simple visual stimuli using two-photon calcium imaging and found that single cells respond in a coarse spatially but not orientation selective manner. Interestingly, activity was strongly modulated by the animals’ locomotion, even in complete darkness. We further investigated the pattern of activity in RSC as mice were trained on a spatial memory task and found evidence for the formation of a memory engram. The stability of this engram was linked to the animals’ performance upon re-exposure to the task.

Audience: Members of the University only

Mon 15 Oct 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Theatre, Headington OX3 7LF

Impact of ageing on the resolution of inflammatory processes in humans

Prof Derek Gilroy

It’s accepted that the aging process alters the innate and adaptive immune system such that vaccine efficacy, for instance, become sub-optimal while wound repair processes are compromised. Moreover, fibroblasts acquire the Senescence-Associated Secretory Phenotype thereby becoming... Read more

It’s accepted that the aging process alters the innate and adaptive immune system such that vaccine efficacy, for instance, become sub-optimal while wound repair processes are compromised. Moreover, fibroblasts acquire the Senescence-Associated Secretory Phenotype thereby becoming hyper-inflammatory while pro-inflammatory cytokines are synthesised more readily and macrophage phagocytosis become impaired. While these disparate effects have been observed in rodents and garnered from various in vitro studies, we investigated the impact of ageing on the onset, progression and resolution of acute inflammation in aged versus young volunteers. Using cantharidin-induced skin blistering as a window into the immune system we found that some aspects of innate immunity weren’t as affected by aged as currently believed, while other phases of the inflammatory cascade, namely resolution, were defective leading to an accumulation of leukocyte debris. We identified the pathway that regulates this defect and found that it could be reversed pharmacologically in the elderly. ---- In 1997 Derek Gilroy obtained his PhD from the William Harvey Research Institute, University of London for investigations in the role of inducible cyclooxygenase in inflammation working with the late Professors Derek Willoughby and Sir John Vane. Thereafter, he left The William Harvey to receive postdoctoral training with Dr. Kenneth Wu, jointly at the University of Houston Texas and at Academia Sinica, Taipei, Tawian from 1998-2000. After which time, he returned to the William Harvey Research Institute for a further 4 years. In 2004, Derek was appointed as New Blood lecturer funded as a Wellcome Trust Career Development Fellow at the Division of Medicine, Rayne Building, University College London. In 2009 he became a Wellcome Trust Senior Research Fellow and in 2010 was promoted to Professor of Experimental Immunology. At University College he is now Head of the Centre for Clinical Pharmacology where he has pioneered research examining the molecular and biochemical pathways that regulates the resolution of acute immune reactions. Prof. Gilroy has won the Bayer International Young Investigator Award for aspirin Research, 2005 and the British Pharmacological Society, Norvartis Award, 2007.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Mon 15 Oct 2018 from 13:00 to 14:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

THIS SEMINAR HAS NOW BEEN CANCELLED - Mechanisms controlling homeostasis in mammalian epidermis

Professor Fiona Watt

Audience: Members of the University only

Organisers: Liz Rose

THIS SEMINAR HAS NOW BEEN CANCELLED 2018 Craig Jordan Lecture

Mon 15 Oct 2018 from 15:00 to 16:00

BDI seminars

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

Phenome@BDI Seminar: Dementia & app development

Dr Chris Hinds, Devesh Batra

Audience: Members of the University only

Organisers: Carol Mulligan-John

Mon 15 Oct 2018 from 19:00 to 20:30

Psychiatry Seminars

Sheldonian Theatre, Broad Street OX1 3AZ

Big Data: curse or cure?

Join Department of Psychiatry’s Prof Simon Lovestone, Nina Hallowell from Wellcome Centre for Ethics and Daniel Kaute from the NIHR Oxford Health Biomedical Research Centre Patients and Research Group for a discussion chaired by writer and broadcaster, Timandra Harkess. Big Data has the potential... Read more

Join Department of Psychiatry’s Prof Simon Lovestone, Nina Hallowell from Wellcome Centre for Ethics and Daniel Kaute from the NIHR Oxford Health Biomedical Research Centre Patients and Research Group for a discussion chaired by writer and broadcaster, Timandra Harkess. Big Data has the potential to save the world. Scientists use it to develop targeted treatments for devastating conditions. But can we trust that our precious information is being safeguarded? There could not be a more timely moment to discuss these issues. A question and answer session will follow the panel discussion. Part of IF Oxford Science and Ideas Festival.

Booking Required

Audience: Public

Tue 16 Oct 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Richard Doll Seminar: Cervical cancer, occult CIN3 and HPV screening

Professor Julian Peto

Audience: Members of the University only

Wed 17 Oct 2018 from 11:00 to 12:30

Ethox Centre and Wellcome Centre for Ethics and Humanities

Big Data Institute, Seminar Room 0, Old Road Campus OX3 7LF

Ethox and WEH Seminar - After the End of Disease: a Historical Perspective on Epidemic Narratives

Dora Vargha

In Rotary’s ad campaign a few years ago, people from Desmond Tutu to Jackie Chan were showing with their hands how close to the end of polio we are. There was even a Gangnam Style version of the ad. The message was that the end is in sight, we are very close and need just one last push to end the... Read more

In Rotary’s ad campaign a few years ago, people from Desmond Tutu to Jackie Chan were showing with their hands how close to the end of polio we are. There was even a Gangnam Style version of the ad. The message was that the end is in sight, we are very close and need just one last push to end the disease targeted by a global eradication program. The ad looks great. You stop and look, perhaps even open your purse to contribute to the cause. But at the same time it is also terribly disturbing: what are these people showing us? What is, exactly, the end of polio? And what comes after? Upon closer inspection, these images open broader questions of how we think about epidemics, disease and ‘solving’ a public health problem. The way we tend to think about diseases, especially in policy-making and in their representations, is within a narrative that comes from epidemics. We talk about an “epidemic” of obesity, of cancer, and further health concerns “plague” our society. Therefore, while various diseases bring up a wide range of different problems to consider, it is important to give epidemics and their narratives a closer look. Using the case of polio eradication in Hungary, I interrogate the ending of an epidemic and place the ‘after’ into the center of analysis. I argue that with this analytical shift, we can gain a more nuanced understanding of what epidemics are, the how we might study them and who and what gets left out of the master narrative of beginning, crisis and end. A focus on endings also highlights the narrative’s shortcomings and the stakes at hand, as epidemic narratives shape global and local health policies.

Audience: Members of the University only

Wed 17 Oct 2018 from 12:30 to 13:00

WHG Lunchtime Lab Talks

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

Jones Group Lunchtime Lab Talk

Dimple Karia, Yuguang Zhou

Jones Group Speaker: Dimple Karia Title: ‘Structural insights into PlexinD1-Semaphorin3E signalling’ Speaker: Yuguang Zhou Title: ‘Win(g)full lunch time (hungry, spicy and coffee)’

Jones Group Speaker: Dimple Karia Title: ‘Structural insights into PlexinD1-Semaphorin3E signalling’ Speaker: Yuguang Zhou Title: ‘Win(g)full lunch time (hungry, spicy and coffee)’

Audience: Members of the University only

Organisers: Isabel Schmidt

Wed 17 Oct 2018 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Unexpected roles of tissue-localized macrophages in the developing CNS

Dr Yosuke Mukoyama

Audience: Members of the University only

Organisers: Anne Farmer

Wed 17 Oct 2018 from 14:00 to 15:00

Development & Cell Biology Theme Guest Speakers (DPAG)

Sherrington Building, Sherrington Library, off Parks Road OX1 3PT

Transcriptional and epigenetic control of vascular homeostasis

Professor Anna M. Randi, MD PhD

Anna Randi is Professor of Cardiovascular Medicine at the National Heart and Lung Institute, Imperial College London. Her research interests are in vascular biology and haemostasis, and in the areas of overlap between these two fields. Major recent findings from the laboratory are the... Read more

Anna Randi is Professor of Cardiovascular Medicine at the National Heart and Lung Institute, Imperial College London. Her research interests are in vascular biology and haemostasis, and in the areas of overlap between these two fields. Major recent findings from the laboratory are the characterisation of endothelial transcriptional networks controlling vascular health, centred on the transcription factor ERG, and the identification of von Willebrand factor as a regulator of blood vessel formation. A major effort has been directed in using circulating endothelial progenitors from patients’ blood, to identify novel mechanisms of disease in patients with the genetic bleeding disorder von Willebrand disease and in patients with CV disease associated with the lung disorder COPD. Anna Randi is a clinically qualified haematologist, specialized in haemostasis and thrombosis. She obtained her medical degrees and PhD from the University of Milan (Italy). She trained at Washington University, St. Louis (USA), in J.E. Sadler’s laboratory where she was involved in the first characterization of mutations in the von Willebrand factor gene. From here she moved to the UK, and began her studies on endothelial biology and vascular diseases. She spent 7 years at GlaxoSmithKline, as group leader and then Head of Translational Medicine (Inflammation); during this time, Anna Randi also held an honorary contract with Imperial College London, where she eventually moved her lab in 2003. Anna Randi serves on BHF grant and fellowship committees, on Wellcome Trust and on international review panels. Between 2014 and 2017 she was on the Editorial Board of Blood. She has served as co-Chair of the Scientific Subcommittee on Vascular Biology of the International Society on Thrombosis and Haemostasis (ISTH). She is a member of numerous scientific organisations, a Fellow of the American Heart Association (FAHA) and member of the ATVB leadership committee. Anna Randi is committed to promoting the careers of young researchers; she believes in providing a supportive and stimulating training and working environment for all, with particular concerns on gender equality. London, May 2018

Audience: Members of the University only

Organisers: Katherine McNeil

Thu 18 Oct 2018 from 10:00 to 11:30

Nuffield Department of Primary Care Health Sciences - External Seminars

St Luke's Chapel, Woodstock Road OX2 6GG

Global health work in Africa

Professor Naomi (Dinky) Levitt

Naomi (Dinky) Levitt is Professor and Head of Diabetic Medicine and Endocrinology at the University of Cape Town and Director of the Chronic Disease Initiative for Africa (CDIA), a network that strives to connect a wide range of experts in NCD public health, clinical medicine, epidemiology,... Read more

Naomi (Dinky) Levitt is Professor and Head of Diabetic Medicine and Endocrinology at the University of Cape Town and Director of the Chronic Disease Initiative for Africa (CDIA), a network that strives to connect a wide range of experts in NCD public health, clinical medicine, epidemiology, lifestyle modification, health economics, health behaviour, implementation research and health service management. Prof Levitt has been integrally involved in the development of guidelines for people with diabetes nationally, regionally and internationally over the past decade. Her research interests are in understanding the burden of diabetes and related cardiovascular disease risk factors, the interaction between chronic infectious and non-infectious diseases and diabetes, and primary health care delivery for diabetes and hypertension. She has participated in numerous national, regional and international diabetes activities. She has led multiple epidemiological and health system studies, has published over 200 articles in peer-reviewed journals and written 12 book chapters.

Audience: Members of the University only

Thu 18 Oct 2018 from 13:00 to 14:00

Medical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Respiratory / Acute General Medicine Firm C

Dr Annabel Nickol, Dr Catherine Ashton, Prof Sarah Pendlebury

Respiratory: "NIV in COPD", Dr Annabel Nickol -- Acute General Medicine Firm C: "The foreign leg", Dr Catherine Ashton and Prof Sarah Pendlebury -- Chair: Prof Chris Conlon

Respiratory: "NIV in COPD", Dr Annabel Nickol -- Acute General Medicine Firm C: "The foreign leg", Dr Catherine Ashton and Prof Sarah Pendlebury -- Chair: Prof Chris Conlon

Audience: Members of the University and NHS clinical staff.

Thu 18 Oct 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

UBVO Seminar: Discussing weight management in primary care - insights from conversation analysis of the BWeL trial

Charlotte Albury

Audience: Members of the University only

Organisers: Graham Bagley

Thu 18 Oct 2018 from 14:00 to 15:30

Experimental Medicine TGU Seminars

Kennedy Institute of Rheumatology, Lecture Theatre, Headington OX3 7LF

Innate barrier function as a therapeutic target in IBD

Dr Zoe Christoforidou, Dr Sumeet Pandey

Audience: Members of the University only

Organisers: Dr Carolina Arancibia

Fri 19 Oct 2018 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Achieving the Holy-Grail: The Humanising Healthcare Methodology

Mr Hamish Dibley

This talk explores a new and refreshing approach to how we understand and improve healthcare systems. Hamish Dibley outlines his alternative approach to realising better healthcare services at less cost. It begins with looking at healthcare not from a conventional activity perspective, but from a... Read more

This talk explores a new and refreshing approach to how we understand and improve healthcare systems. Hamish Dibley outlines his alternative approach to realising better healthcare services at less cost. It begins with looking at healthcare not from a conventional activity perspective, but from a person-centred one. Abstract The NHS must change the way it operates to effectively meet future challenges. The starting point for improved services at less cost rests on more intelligent use of data to inform future performance improvement through system and service redesign. Hamish Dibley will talk about his work in applying genuine patient-centred principles to healthcare analysis and service design. This alternative approach – The Humanising Healthcare Methodology – to realising better healthcare services and less cost begins with looking at healthcare not from an activity perspective but from a person-centred one. Unlike existing practice, the work establishes time-series data to interpret the true nature of person demand for acute services, to better understand the root cause(s) of service challenges facing commissioners and providers alike. Understanding patient demand is the first step in arriving at intelligent system and service redesign solutions around patient cohorts. This informs a more integrated and preventive system that will successfully alter the nature and consumption curve for care and reduce costs across the system. This radical and elegant approach provides for innovative thinking as to how to propose future improvement schemes, not only to reduce patient demand but also to better respond to, and therefore manage, such demand. This latter aim requires proof of concepts to test new approaches and processes with a small cohort of patients. This work serves to inform and constructively challenge current cost and quality improvement programme plans, as well as provide the basis for healthcare integration. Moreover, this way of working provides a better approach to overcoming the principal performance challenges facing all healthcare economies - A&E breaches, delayed transfers of care, and waiting time lists for planned care.

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 19 Oct 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Fri 19 Oct 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Synaptic dynamics in mouse visual cortex following sensory deprivation

Dr Tara Keck

Homeostatic synaptic scaling is thought to occur cell-wide, but recent evidence suggests this form of stabilizing plasticity can be implemented more locally in reduced preparations. To investigate the spatial scales of plasticity in vivo, we used repeated two-photon imaging in mouse visual cortex... Read more

Homeostatic synaptic scaling is thought to occur cell-wide, but recent evidence suggests this form of stabilizing plasticity can be implemented more locally in reduced preparations. To investigate the spatial scales of plasticity in vivo, we used repeated two-photon imaging in mouse visual cortex after sensory deprivation to measure TNF-α dependent increases in spine size as a proxy for synaptic scaling in vivo in both excitatory and inhibitory neurons. We found that after sensory deprivation, increases in spine size are restricted to a subset of dendritic branches, which we confirmed using immunohistochemistry. We found that the dendritic branches that had individual spines that increased in size following deprivation, also underwent a decrease in spine density. Within a given dendritic branch, the degree of spine size increases is proportional to recent spine loss within that branch. Using computational simulations, we show that this compartmentalized form of synaptic scaling better retained the previously established input-output relationship in the cell, while restoring activity levels. We then investigated the relationship between new spines that form after this spine loss and strengthening and find that their spatial positioning facilitates strengthening of maintained synapses.

Audience: Members of the University only

Fri 19 Oct 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre , Old Road Campus OX3 7LF

Richard Doll Seminar: Cervical Screening in a post-HPV immunisation world

Dr Timothy Palmer

Tim trained in pathology at various hospitals around London, including the Royal Marsden Hospital. Appointed Consultant Pathologist at Guy's in 1989, he moved to Inverness in late 1990. His responsibilities there were for lab aspects of cervical screening and lab computerisation. He was involved... Read more

Tim trained in pathology at various hospitals around London, including the Royal Marsden Hospital. Appointed Consultant Pathologist at Guy's in 1989, he moved to Inverness in late 1990. His responsibilities there were for lab aspects of cervical screening and lab computerisation. He was involved in developing the Scottish Cervical Screening Programme, including the introduction of liquid based cytology, image assisted screening and a national screening computer system. Although retired from full time practice, he is Clinical Lead for Cervical Screening in Scotland. He was closely involved in the development of the business case for primary HPV screening in Scotland and is the Lead Clinician for HPV Primary Screening implementation. He was appointed Honorary Senior Lecturer at Edinburgh University in 2014 to allow continuation of his research interests. Outside pathology, he has diverse interests, including singing early music as a male alto, food and wine, ceramics, renovating an old house, and maintaining a classic sports car. He is currently involved in a research project at Raigmore involving the use of basket-making in rehabilitation from stroke and traumatic/toxic head injury.

Audience: Members of the University only

Mon 22 Oct 2018 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, Meeting Rooms 71a,b,c, Headington OX3 7DQ

Disassembly of replication machinery at termination of DNA replication forks

Dr Agnieszka Gambus

Audience: Members of the University only

Organisers: Amanda O'Neill

Mon 22 Oct 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

Dysregulation of cartilage and bone growth in osteoarthritis

Prof Max Loehning

The Pitzer Laboratory of Osteoarthritis Research investigates cellular and molecular mechanisms leading to the development of osteoarthritis. Our hypothesis is that environmental signals such as overloading, injury or inflammation trigger stress in chondrocytes. Under stress, they then produce... Read more

The Pitzer Laboratory of Osteoarthritis Research investigates cellular and molecular mechanisms leading to the development of osteoarthritis. Our hypothesis is that environmental signals such as overloading, injury or inflammation trigger stress in chondrocytes. Under stress, they then produce inferior cartilage, degrade articular cartilage or undergo apoptosis. In three-dimensional cell cultures of human chondrocytes under hypoxia, we show that stimulation of selected Toll-like receptors impairs cartilage matrix production and induces a catabolic, inflammatory state. Furthermore, we identified candidate genes that may control the growth of blood vessels and bone in the joint area. This finding could be therapeutically useful to limit cartilage ossification and the formation of osteophytes in osteoarthritis. ---- Prof. Dr. Max Löhning is head of the Pitzer Laboratory of Osteoarthritis Research at the German Rheumatism Research Center Berlin (DRFZ) and at the Charité – University Medicine Berlin. M.L. studied Biology at the University of Mainz and did his dissertation in immunology at the Institute of Genetics, University of Cologne (2000). He was a visiting researcher at William E. Paul (NIH, NIAID, Bethesda, MD), and at Kenneth M. Murphy (Washington University-School of Medicine, St. Louis, MO), USA, and then a postdoctoral fellow of Schering Foundation with Rolf M. Zinkernagel and Hans Hengartner at the Institute of Experimental Immunology, ETH and University Hospital Zurich, Switzerland (2003-2006). Then he was appointed Lichtenberg Professor of Experimental Immunology, supported by Volkswagen Foundation, at the Charité – University Medicine Berlin (2006-2015). In 2015, he was appointed University Professor of Osteoarthritis Research at the Charité and head of the Pitzer Laboratory of Osteoarthritis Research, funded by Willy Robert Pitzer Foundation, at the DRFZ Berlin. He was awarded several prizes: the Georges-Köhler-Prize (2010) and Otto-Westphal-Prize (2000) from the German Society for Immunology (DGfI), the Avrion-Mitchison-Prize for Rheumatology (2000) of the Ernst Schering Foundation, and the Robert Koch Foundation’s Postdoctoral Award (2004). He is member of the Berlin-Brandenburg Academy of Sciences and spokesperson of the class Biological Sciences and Medicine.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Mon 22 Oct 2018 from 16:00 to 17:30

Seminars in the History of Science, Medicine, and Technology

History Faculty - Lecture Room, https://www.admin.ox.ac.uk/access/dandt/humanities/oldboyshighschool/

Archival ethics from below: the case of an African Cancer Hospital

Dr Marissa Mika

At the Uganda Cancer Institute, lines often blur between past and present, sickness and health, life and death. Founded in 1967 as a small chemotherapy clinical trials facility in Kampala, today the Institute’s 60 beds serve a population catchment of over 40 million living in the Great Lakes... Read more

At the Uganda Cancer Institute, lines often blur between past and present, sickness and health, life and death. Founded in 1967 as a small chemotherapy clinical trials facility in Kampala, today the Institute’s 60 beds serve a population catchment of over 40 million living in the Great Lakes region of Africa. The Institute houses the only continuous collection of patient records documenting cancer treatment and care on the African continent. This talk considers the temporal, methodological, and ethical challenges of preserving patient records at the Uganda Cancer Institute.

Audience: Members of the University only

Organisers: Professor Rob Iliffe

Tue 23 Oct 2018 from 11:00 to 12:00

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

CANCELLED: Vector-mediated prophylaxis against airborne infectious viruses

Professor Maria Limberis

Audience: Members of the University only

Organisers: Anne Farmer

Tue 23 Oct 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Richard Doll Seminar: Livestock, Health, Environment & People

Professor Charles Godfray

Audience: Members of the University only

Tue 23 Oct 2018 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Discovery of cellular and molecular targets to extend hematopoietic healthspan

Dr Jennifer Trowbridge

Audience: Members of the University only

Organisers: Liz Rose

Wed 24 Oct 2018 from 11:00 to 12:30

Ethox Centre and Wellcome Centre for Ethics and Humanities

Big Data Institute, Seminar Room 0, Old Road Campus OX3 7LF

Ethox and WEH Seminar - The ethics and epistemology of nocebo effects in trials, and what to do about it

Dr Jeremy Howick

A recent systematic review found that almost half of participants who take placebos in clinical trials experience drug related adverse events (AEs), with 5% of participants dropping out due to ‘drug related’ intolerance. However the placebo per se cannot be the cause of these adverse events.... Read more

A recent systematic review found that almost half of participants who take placebos in clinical trials experience drug related adverse events (AEs), with 5% of participants dropping out due to ‘drug related’ intolerance. However the placebo per se cannot be the cause of these adverse events. Instead, there are two overlapping likely explanations: 1. Misattribution A patient may have an underlying condition whose natural history produces some event (such as a headache), then the patient misattributes the event to the placebo. 2.Nocebo effects Having been warned about side effects in the patient information sheets, the patient may expect an adverse event. This negative expectation could then produce the event. Nocebo effects may be caused—at least partly—by sharing information about AEs in the wrong way. This causes a tension between the ethical requirements of autonomy and non-maleficence. On the one hand, autonomy demands that patients be fully informed about treatment (adverse events). On the other hand, non-maleficence demands that patients be informed about AE’s in the right way. Ethical discussions of informed consent have focused almost exclusively on autonomy and may therefore been violating the requirement to do no harm. I will discuss ways in which autonomy and non-maleficence can be balanced in future clinical trials and ethical debates.

Audience: Members of the University only

Wed 24 Oct 2018 from 12:00 to 13:00

Peter Medawar Building Seminars

Medawar Building, Level 30 Seminar Room, off South Parks Road OX1 3SY

Environmental DNA for wildlife epidemiology and outbreak investigation

Dr Sebastien Calvignac

The wildlife component of the human/wildlife interfaces where zoonotic pathogens emerge is usually very poorly characterized. This is true both for the wildlife communities themselves and for their parasites. Ecological and veterinary investigations are absolutely required but the infrastructure... Read more

The wildlife component of the human/wildlife interfaces where zoonotic pathogens emerge is usually very poorly characterized. This is true both for the wildlife communities themselves and for their parasites. Ecological and veterinary investigations are absolutely required but the infrastructure and manpower needed prevent their broad deployment. Fecal sample analyses are now frequently used to magnify our ability to monitor wildlife and their pathogens. In this presentation, I will show how we can extend our toolkit by using other sources of environmental DNA, with a strong focus on invertebrate-derived DNA.

Audience: Members of the scientific community

Organisers: Professor Sunetra Gupta

please arrive five minutes before the seminar to allow entry to the building

Wed 24 Oct 2018 from 14:00 to 15:00

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Advanced single-molecule imaging of cellular proteins, from surface to nucleus

Dr Aleks Ponjavic

Audience: Members of the University only

Organisers: Anne Farmer

Thu 25 Oct 2018 from 13:00 to 14:00

Medical Grand Rounds

OCDEM / Rheumatology

Prof David Ray, Dr Hamish Reid, Dr Natasha Jones, Dr Ralph Smith, Dr Stefan Kluzek

OCDEM: "Glucocorticoid action, and inaction", Prof David Ray -- Rheumatology: "What can Moving Medicine do for you?", Dr Natasha Jones, Dr Hamish Reid, Dr Ralph Smith and Dr Stefan Kluzek -- Chair: Prof Chris O'Callaghan

OCDEM: "Glucocorticoid action, and inaction", Prof David Ray -- Rheumatology: "What can Moving Medicine do for you?", Dr Natasha Jones, Dr Hamish Reid, Dr Ralph Smith and Dr Stefan Kluzek -- Chair: Prof Chris O'Callaghan

Audience: Members of the University and NHS clinical staff.

Thu 25 Oct 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

* CANCELLED * UBVO Seminar: Function of fat. What are the determinants and does it matter?

Marijana Todorčević

Audience: Members of the University only

Organisers: Graham Bagley

Fri 26 Oct 2018 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Genes, Hands, Nerves, and Brains

Dominic Furniss, Dr Akira Wiberg

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 26 Oct 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Exploring the immunology in autoantibody mediated diseases of the central nervous system

Associate Professor Sarosh Irani

Audience: Members of the University only

Organisers: Anne Farmer

Fri 26 Oct 2018 from 10:30 to 12:00

WHG Seminars

Wellcome Trust Centre for Human Genetics, CCMP2 , Headington OX3 7BN

SINGLE CELL SEMINARS - WELLCOME CENTRE FOR HUMAN GENETICS

SINGLE CELL SEMINARS - WELLCOME CENTRE FOR HUMAN GENETICS Friday, October 26, 2018 CCMP2 10:30 - 1200 Adam Cribbs, title TBC for info, please email curion@well.ox.ac.uk

SINGLE CELL SEMINARS - WELLCOME CENTRE FOR HUMAN GENETICS Friday, October 26, 2018 CCMP2 10:30 - 1200 Adam Cribbs, title TBC for info, please email curion@well.ox.ac.uk

Audience: Members of the University only

Fri 26 Oct 2018 from 11:00 to 12:00

Strubi seminars

Determining the energy dependence of radiation damage in electron cryo-microscopy of biological specimens

Dr Christopher Russo

Radiation damage sets the ultimate limit to structure determination using any form of ionizing radia-tion with sufficient energy to resolve the positions of atoms in a molecule. Electrons, since they interact strongly with biological specimen, induce severe radiation damage, but also provide... Read more

Radiation damage sets the ultimate limit to structure determination using any form of ionizing radia-tion with sufficient energy to resolve the positions of atoms in a molecule. Electrons, since they interact strongly with biological specimen, induce severe radiation damage, but also provide maxi-mal contrast per unit damage event when compared to X-rays and neutrons [1]. While the amount of information per unit damage for electrons is thought to be approximately constant over the ener-gy range of 10 to 1000 keV, published measurements of radiation damage to biological specimen are not of sufficient accuracy to determine if there is an advantage, in terms of contrast per unit damage, to reducing or increasing the energy of the electron beam. Recently, our measurements of specimen charging [2-3] and the demonstration of a new method of Ewald sphere correction [4] indicate that neither of these present a barrier for reducing the energy of the electron beam from 300 keV, which is the current standard for most commercial high-resolution electron cryomicro-scopes. Some theoretical estimates indicate that the ratio of the inelastic to elastic scattering cross sections for carbon may drop by as much as 30% from 300 to 100 keV [5]. With this in mind, we wish to understand both theoretically and experimentally, if there is a potential advantage in terms of radiation damage, in changing the energy of the electron from the conventional 300 keV used for most cryoEM. Here we present our recent progress in measuring how the amount of structural information in electron cryomicrographs of biological specimen scales vs. damage when changing the energy of the incident electron beam. We measure the high energy elastic scattering cross sec-tions of carbon to high accuracy using pure carbon specimens. We compare these data to estab-lished theory of electron scattering as well as measurements of damage using the fading of diffrac-tion spots from 2D crystals of paraffin and bacteriorhodopsin (purple membrane). From these measurements, we find that there will likely be an optimum energy for imaging a biological speci-men of a given thickness with electrons, assuming that the various technical hurdles to producing efficient detectors at lower energies, can be overcome. References [1] Henderson, R QRB 1995. [2] Russo CJ & Henderson R, Ultramicroscopy 2018a. [3] Russo CJ & Henderson R, Ultramicroscopy 2018b. [4] Russo CJ & Henderson R, Ultramicroscopy 2018c. [5] Edgerton R. et al. Micron 2014.

Audience: Members of the University only

Organisers: Agata Krupa

Fri 26 Oct 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Library, off Parks Road OX1 3PT

Genetic regulators of cardiovascular development

Dr Kelly Smith

We are dependent on our cardiovascular system for life support. Defects in the formation of either the heart or vasculature can be fatal in utero, reflecting our dependency on this system from almost the earliest stages of life. The cardiovascular system is remarkably stereotypical in its... Read more

We are dependent on our cardiovascular system for life support. Defects in the formation of either the heart or vasculature can be fatal in utero, reflecting our dependency on this system from almost the earliest stages of life. The cardiovascular system is remarkably stereotypical in its structure, both between individuals and across species. This demonstrates that a strict genetic programme dictates this structure and that the programme is conserved. Focussing primarily on the early stages of heart development, we utilise the zebrafish model for its genetic tractability to identify regulators of cardiovascular development. Using forward genetics, we have discovered several novel regulators of cardiac and vascular development. One such regulator is a novel Hyaluronidase, named Cemip2 (formerly Tmem2), that is required for both cardiac development and angiogenesis. Early data suggests that the function of this protein is conserved in mammals. We have also identified a regulator of N-cadherin trafficking and show that it is required for cardiomyocyte cell adhesion. Whilst exciting for discovery’s sake, this fundamental knowledge is essential for understanding inherited cardiovascular diseases and in plying our knowledge to devise therapeutic strategies.

Audience: Members of the University only

Mon 29 Oct 2018 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, Meeting rooms 71a,b,c, Headington OX3 7DQ

The role of ATRX in repairing internal and telomeric DNA double-strand breaks

Professor Markus Löbrich

Audience: Members of the University only

Mon 29 Oct 2018 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

Inflammation and Microbiome in Cancer and Irritable Bowel Syndrome

Dr Ze'ev Ronai

Audience: Members of the University only

Organisers: Christina Woodward

Mon 29 Oct 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

Multimodal mass spectrometry imaging of tumours

Prof Josephine Bunch

Mass spectrometry (MS) is one of the most powerful techniques for chemical analysis and when combined with an imaging modality allows molecular chemistry to be visualised in 2D and 3D, from the nano- to the macroscale, in ambient conditions and in real‐time. There are numerous techniques each... Read more

Mass spectrometry (MS) is one of the most powerful techniques for chemical analysis and when combined with an imaging modality allows molecular chemistry to be visualised in 2D and 3D, from the nano- to the macroscale, in ambient conditions and in real‐time. There are numerous techniques each having different modes of operation including label‐free and labelled analyses. In 2017 the CRUK Grand Challenge programme was launched. By pursuing a multiscale (organ to organelle) and multi-omics approach with a range of mass spectrometry imaging (MSI) techniques (MALDI, DESI, SIMS and ICP MS), we aim to deepen our understanding of the interplay of genes, proteins, metabolites and the role of the immune system in cancer development and growth. This presentation will review early results and a discussion of the challenges associated with such a large, multi-technique, multi-site, mass spectrometry project. ---- Professor Josephine Bunch is a Principal Scientist and Co-Director of the National Centre of Excellence in Mass Spectrometry Imaging (NiCE-MSI) at NPL and Chair of Biomolecular Mass Spectrometry at Imperial College London. She is currently leading a Cancer Research UK Grand Challenge programme (2017-2022; £16 million). She has expertise in a range of mass spectrometry imaging techniques and her group at NPL comprises a multidisciplinary team of around 20 people. To support innovation and instrument development for MSI, Josephine leads a large programme of research and metrology in MALDI and ambient mass spectrometry imaging, funded by the National Measurement System. Within this project a new transmission mode, atmospheric MALDI ion source, with dual mode post-ionisation has been constructed. The group also hosts and co-supervises Ph.D. students from the University of Nottingham, the University of Birmingham, Imperial College London, Oxford University and the University of Surrey.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Mon 29 Oct 2018 from 12:00 to 13:00

BDI seminars

Big Data Institute, Seminar Room 0, Old Road Campus OX3 7LF

Infections@BDI Seminar

Simon Dellicour, Azim Ansari

Audience: Members of the University only

Organisers: Carol Mulligan-John

Mon 29 Oct 2018 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Salmonella persisters during infection

Dr Sophie Helaine

Audience: Members of the University only

Organisers: Liz Cloke

Mon 29 Oct 2018 from 15:00 to 16:00

BDI seminars

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

Phenome@BDI Seminar: Meta catalogue of OUH clinical databases

James Welch

Audience: Members of the University only

Organisers: Carol Mulligan-John

Mon 29 Oct 2018 from 16:00 to 17:30

Seminars in the History of Science, Medicine, and Technology

History Faculty - Lecture Room, https://www.admin.ox.ac.uk/access/dandt/humanities/oldboyshighschool/

Smallpox eradication in China and emerging narratives of global health, 1949-79

Dr Mary Brazelton

In the Cold War, East Asian nations became involved in a variety of transnational health initiatives. Although Taiwan, South Korea, and Japan all provided support to the World Health Organization and its American-oriented interventions and strategies, the non-aligned People’s Republic of China... Read more

In the Cold War, East Asian nations became involved in a variety of transnational health initiatives. Although Taiwan, South Korea, and Japan all provided support to the World Health Organization and its American-oriented interventions and strategies, the non-aligned People’s Republic of China followed a different path. The public success of mass immunization in China, as determined by the eradication of smallpox and the “control” of other infectious diseases like measles and cholera in the 1950s and 1960s, contributed crucial evidence for the success of Chinese public health more broadly. By the 1970s, immunization was comfortably entrenched in the rural health system that the People’s Republic of China promoted on a global scale via the export of medical materials, personnel, and funds. State agents also cultivated the goodwill of Western observers who traveled to China after 1971. These international activities contributed to the prominence of the PRC in discussions of global health policy, culminating in the World Health Organization’s Alma-Ata Declaration of 1978 and its major policy shift towards promoting primary health care: interventions meant to provide basic clinical services for many people, including those in rural areas. Although the PRC became famous for its “barefoot doctors” as the human faces of the rural health system it promoted, its eradication and control of infectious diseases—a consequence of mass immunization—provided key evidence that helped consolidate its position as a leading national model of public health.

Audience: Members of the University only

Organisers: Professor Rob Iliffe

Tue 30 Oct 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Richard Doll Seminar: The genetics of stroke

Professor Hugh Markus

Hugh Markus is Professor of Stroke Medicine and Honorary Consultant Neurologist in the Department of Clinical Neurosciences at the University of Cambridge. He was Professor of Neurology at St George’s, University of London, before moving to his current post in 2013. He spends approximately half... Read more

Hugh Markus is Professor of Stroke Medicine and Honorary Consultant Neurologist in the Department of Clinical Neurosciences at the University of Cambridge. He was Professor of Neurology at St George’s, University of London, before moving to his current post in 2013. He spends approximately half of his time in clinical care of stroke patients. This includes running a National CADASIL/stroke genetics clinic. His main areas of research interest are the genetics of stroke, where he applies genetic and imaging techniques to investigate the pathogenesis of stroke and develop new treatments, cerebral small vessel disease and clinical trials. He was disease lead for the Wellcome Trust Case Control Consortium 2 (WTCCC2) ischaemic stroke study and established the METASTROKE Genetics consortium. He has a particular interest in small vessel disease and vascular cognitive impairment and pursues genetic and MRI approaches to investigate disease mechanisms.

Audience: Members of the University only

Tue 30 Oct 2018 from 14:30 to 15:30

WHG Seminars

Wellcome Trust Centre for Human Genetics, Room A, Headington OX3 7BN

The gut-microbiota connection in type 1 diabetes

Dr Emma Hamilton-Williams

While disturbances in the gut microbiota have been associated with type 1 diabetes progression, the causes of this dysbiosis and the consequences to the host are largely unknown. Using a unique multi-omic approach, we explore the functional link between the gut, pancreas and microbiota in type 1... Read more

While disturbances in the gut microbiota have been associated with type 1 diabetes progression, the causes of this dysbiosis and the consequences to the host are largely unknown. Using a unique multi-omic approach, we explore the functional link between the gut, pancreas and microbiota in type 1 diabetes. In complementary genetic studies, we show that immune loci linked to type 1 diabetes susceptibility contribute to shaping the gut microbiota.

Audience: Members of the University only

Organisers: Isabel Schmidt

Wed 31 Oct 2018 from 11:00 to 12:30

Ethox Centre and Wellcome Centre for Ethics and Humanities

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

Ethox and WEH Seminar: Current controversies in public patient involvement in research and service delivery

Lucy Frith

It is only recently that PPI has been seen as a key part of healthcare practice and some form of PPI has been almost universally adopted throughout the NHS in England. However, although it is widely recognised that PPI is important by a wide range of different groups, from activists and patient... Read more

It is only recently that PPI has been seen as a key part of healthcare practice and some form of PPI has been almost universally adopted throughout the NHS in England. However, although it is widely recognised that PPI is important by a wide range of different groups, from activists and patient groups, professional organisations to government bodies, within this broad endorsement there are a host of unresolved issues: what is the overriding justification and value base of PPI? There is also uncertainty over what the role of the PPI contributor is or should be and what such roles contribute to decision-making? This paper will consider these issues and how these, possibly, competing rationales for PPI affect the assessment PPI activities.

Audience: Members of the University only

Organisers: Christa Henrichs