Other Seminars

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Tue 7 Aug 2018 from 13:00 to 14:00

Jenner Seminars

Old Road Campus Research Building, Seminar Room, Lower Ground Floor, Headington OX3 7DQ

Rapid Response Pipeline for Stabilized Subunit Vaccines

Dr Keith Chappell

Audience: Member of the University of Oxford and The Pirbright Institute

Organisers: Lisbeth Soederberg

Thu 16 Aug 2018 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

The role of Keratins in modulating carcinogenesis via communication with cells of the immune system

Ines Sequeira

The inability to resolve chronic inflammation is considered one of the initial triggers of carcinogenesis. Until recently, keratins were mainly regarded as cytoskeletal scaffolds; however, there is an emerging role for keratins in the regulation of epidermal immunity. Keratin 76 (Krt76) is... Read more

The inability to resolve chronic inflammation is considered one of the initial triggers of carcinogenesis. Until recently, keratins were mainly regarded as cytoskeletal scaffolds; however, there is an emerging role for keratins in the regulation of epidermal immunity. Keratin 76 (Krt76) is expressed in the differentiated epithelial layers of skin, oral cavity and squamous stomach. Krt76 downregulation in human oral squamous cell carcinomas correlates with poor prognosis. We show that genetic ablation of Krt76 in mice leads to spleen and lymph node enlargement, an increase in regulatory T cells (Tregs) and high levels of pro-inflammatory cytokines. Krt76-/- Tregs have increased suppressive ability correlated with increased CD39 and CD73 expression. The Krt76-/- mouse serves as a model to explore the link between chronic inflammation and cancer, providing an opportunity to examine the impact of aberrant epithelial differentiation and consequent chronic inflammation on tumorigenesis. We observed that loss of Krt76 increases carcinogen-induced tumours in tongue and squamous stomach. The carcinogenesis response includes upregulation of pro-inflammatory cytokines and enhanced accumulation of Tregs in the tumour microenvironment. This study highlights the importance of keratins as immunomodulators and demonstrates their importance in tumour progression.

Audience: Members of the University only

Organisers: Christina Woodward

Tue 28 Aug 2018 from 10:30 to 11:30

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

NPEU Seminar: TBC (Maternal and Newborn health in the community – Uganda/UK collaboration)

Dr Christine Nalwadda Kayemba

Audience: Members of the University only

Organisers: Graham Bagley

Thu 30 Aug 2018 from 16:30 to 18:30

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, George Pickering Education Centre, Department of Medical Education, Level 3, Room 2B, Headington OX3 9DU

Gastrointestinal stem cells as targets, sensors and effectors of bacterial infections

Dr. Michael Sigal

Audience: Members of the University only

Organisers: Dr Holm Uhlig