Other Seminars

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Fri 4 Oct 2019 from 16:00 to 17:00

Development & Cell Biology Theme Guest Speakers (DPAG)

Sherrington Library, off Parks Road OX1 3PT

The dynamics of cell identity: explorations in mammalian embryos

Anna-Katerina Hadjantonakis

Developmental and stem cell biologist Anna-Katerina (Kat) Hadjantonakis is a Member of the Developmental Biology Program at the Sloan Kettering Institute and a Professor at Cornell University in New York, USA. Her lab seeks to understand how cells regulate their identity, and how they coordinately... Read more

Developmental and stem cell biologist Anna-Katerina (Kat) Hadjantonakis is a Member of the Developmental Biology Program at the Sloan Kettering Institute and a Professor at Cornell University in New York, USA. Her lab seeks to understand how cells regulate their identity, and how they coordinately and reproducibly build complex organs in mammalian embryos, and in in vitro stem cell and organoid models. She received a BSc in Biochemistry in 1990, and PhD in Molecular Genetics in 1995, from Imperial College London, UK. She then undertook postdoctoral training, first with Drs. Andras Nagy at the Lunenfeld-Tanenbaum Research Institute, Toronto, Canada, and thereafter with Dr. Virginia Pappaioannou at Columbia University, New York, USA. She established her independent research group at Sloan Kettering in 2004. She currently serves on the editorial boards of journals including Developmental Cell, Development and Developmental Biology. She is a standing member of grant review panels and advisory committees for the NIH, the NSF, the UK’s Wellcome Trust, and the European Research Council.

Audience: Members of the University only

Organisers: Katherine McNeil

Tue 8 Oct 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Title TBC

Dr Mads Gyrd-Hansen

Audience: Members of the University only

Organisers: Liz Rose

Wed 9 Oct 2019 from 09:30 to 10:30

Tropical Medicine Seminars

NDM Building, Basement seminar room, Headington OX3 7FZ

TropMed webinar: Mapping and Tracking Malaria

Prof Arjen Dondorp, Dr Susan Rumisha

Audience: Members of the University only

Organisers: Claire-Lise Kessler

The seminar will be shared via Zoom. Contact Claire-Lise Kessler if you want to join

Mon 14 Oct 2019 from 16:00 to 17:00

Burdon Sanderson Cardiac Science Centre Lecture Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Cardiovascular diseases and drugs: hiPSC models moving forward

Christine Mummery

Cardiovascular cells derived from hPSC are of growing interest for drug discovery and toxicity. Our lab has been investigating microphysiological solutions using multicellular cardiac microtissues to quantify the outcomes of drug and disease mutation responses in situ. Isogenic pairs of hiPSC have... Read more

Cardiovascular cells derived from hPSC are of growing interest for drug discovery and toxicity. Our lab has been investigating microphysiological solutions using multicellular cardiac microtissues to quantify the outcomes of drug and disease mutation responses in situ. Isogenic pairs of hiPSC have proven essential to compensate interline variability. We have shown that iPSC derived cardiomyocytes with mutations in ion channel genes can accurately predict changes in cardiac electrical properties and reveal drug sensitivities also observed in patients. Biography: Christine Mummery studied physics at the University of Nottingham, UK and has a PhD in Biophysics from the University of London. After positions as postdoc and tenured group leader at the Hubrecht Institute, she became professor at the University Medical Centre Utrecht in 2002. After a sabbatical at the Harvard Stem Cell Institute in 2007, she introduced human iPS cells to the Netherlands. In 2008, she became Professor of Developmental Biology at Leiden University Medical Centre in the Netherlands and head of the Department of Anatomy and Embryology. Her research concerns heart development and the differentiation of pluripotent human stem cells into the cardiac and vascular lineages and using these cells as disease models, for safety pharmacology and drug discovery. Immediate interests are on developing biophysical techniques for characterization and functional analysis of cardiovascular cells from hPSC. In 2015 she became guest professor at the Technical University of Twente to develop organ-on-chip models. She was recently awarded a multimillion grant for this purpose and is awardee of a prestigious European Research Council Advanced Grant. She is a member of the Royal Netherlands Academy of Science (KNAW), and board member and incoming president of the International Society of Stem Cell research (ISSCR); she is also former board of the KNAW and the Netherlands Medical Research Council (ZonMW). She was awarded the Hugo van de Poelgeest Prize for Animal Alternatives in research, has co-authored a popular book on stem cells “Stem Cells: scientific facts and Fiction” (2nd edition 2014) and is editor in chief of the ISSCR journal Stem Cell Reports. She is also on the editorial boards of Cell Stem Cell, Cardiovascular Research and Stem Cells.

Audience: Members of the University only

Tue 15 Oct 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Floor meeting - 2 groups will give an update on the research work in their laboratory

Audience: Members of the University only

Organisers: Liz Rose

Tue 15 Oct 2019 from 16:00 to 17:00

OPDC Seminar Series (DPAG)

Sherrington Library, off Parks Road OX1 3PT

Title TBC

Professor Paolo Calabresi

In the last two decades, Prof. Calabresi’s research has investigated the synaptic communication between the cerebral cortex and the basal ganglia, focussing on corticostriatal synapses and their activity-dependent plasticity. In particular, Prof. Calabresi’s group has extensively investigated... Read more

In the last two decades, Prof. Calabresi’s research has investigated the synaptic communication between the cerebral cortex and the basal ganglia, focussing on corticostriatal synapses and their activity-dependent plasticity. In particular, Prof. Calabresi’s group has extensively investigated how corticostriatal communication depends on the activation of dopamine receptors and how it is affected by pathological conditions such as Parkinson’s disease. The research group coordinated by Prof. Calabresi has been the first, in 1992, to describe a novel form of striatal synaptic plasticity, named long-term-depression (LTD). This vital feature of corticostriatal synapses has then be synaptic plasticity, named long-term-depression (LTD). This vital feature of corticostriatal synapses has then been fully characterised by Prof Calabresi’s group from a pharmacological and electrophysiological point of view.

Audience: Members of the University only

Organisers: Professor Richard Wade-Martins

Thu 17 Oct 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, NDMRB (TDI) seminar room, Headington OX3 7FZ

“A multifaceted interplay between metabolism and epigenetics determines how CAFs remodel the tumour stroma”

Professor Sara Zanivan

Audience: Members of the University only

Organisers: Alexandra Ward

Tue 22 Oct 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Title TBC

Dr Jan Korbel

Audience: Members of the University only

Organisers: Liz Rose

Thu 24 Oct 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, TDI seminar room, lower ground floor, Headington OX3 7FZ

Rho GTPase signalling in cancer migration and invasion

Professor Anne Ridley

Audience: Members of the University only

Organisers: Alexandra Ward

Mon 28 Oct 2019 from 16:00 to 17:00

OPDC Seminar Series (DPAG)

Sherrington Building, Small Lecture Theatre (2nd Floor), off Parks Road OX1 3PT

Title TBC

Dr Ellen Sidransky

Dr. Sidransky, chief of the Molecular Neurogenetics Section, is a pediatrician and clinical geneticist in the Medical Genetics Branch of the National Human Genome Research Institute at the National Institutes of Health in Bethesda, Maryland. Dr. Sidransky has been a tenured investigator at NIH and... Read more

Dr. Sidransky, chief of the Molecular Neurogenetics Section, is a pediatrician and clinical geneticist in the Medical Genetics Branch of the National Human Genome Research Institute at the National Institutes of Health in Bethesda, Maryland. Dr. Sidransky has been a tenured investigator at NIH and a section chief since 2000. Her research includes both clinical and basic research aspects of Gaucher disease and Parkinson's disease, and her group first identified glucocerebrosidase as a risk factor for parkinsonism. She has spearheaded two large international collaborative studies regarding the genetics of Parkinson's disease and dementia with Lewy bodies. Her current work also focuses on understanding the complexity encountered in "simple" Mendelian disorders, the association between Gaucher disease and parkinsonism and the development of small molecule chaperones as therapy for Gaucher disease and potentially parkinsonism. Dr. Sidransky directs two NIH clinical protocols, one evaluating patients with lysososmal storage disorders and the second prospectively studying patients and relatives with parkinsonism who carry mutations in GBA.

Audience: Members of the University only

Organisers: Melanie Witt