Other Seminars

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Fri 1 Mar 2019 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Global Surgical Care—Here we are, but where are we going?

Dr Walter Johnson

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 1 Mar 2019 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

Title TBC

Ho Group

Audience: Members of the University only

Organisers: Anne Farmer

Fri 1 Mar 2019 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Attention: Hippocampal long-term potentiation (LTP) might be important after all!

Professor David Bannerman

Marianne Fillenz Annual Lecture 2019 Several lines of evidence, including recent GWAS, have suggested that schizophrenia may be a disorder of impaired synaptic plasticity, particularly in the hippocampus. Traditionally, hippocampal synaptic plasticity (e.g. long-term potentiation) has been thought... Read more

Marianne Fillenz Annual Lecture 2019 Several lines of evidence, including recent GWAS, have suggested that schizophrenia may be a disorder of impaired synaptic plasticity, particularly in the hippocampus. Traditionally, hippocampal synaptic plasticity (e.g. long-term potentiation) has been thought to subserve the formation of associative memories. Yet schizophrenic subjects are often considered to be more, rather than less, likely to form associations, which is thought to underlie the generation of their false beliefs and delusions. I will present data showing that ablating key glutamate receptor subunits involved in hippocampal synaptic plasticity (and implicated in schizophrenia) leads to deficits in a form of non-associative short-term memory that underlies the habituation of attention. This generates aberrant salience, hyperdopaminergic responses and increased theta coherence, and an increased (rather than decreased) propensity to form associations, reminiscent of what is seen in schizophrenic patients. The implications of these results for understanding synaptic homeostasis during sleep will also be discussed.

Audience: Members of the University only

Mon 4 Mar 2019 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, Meeting Rooms 71a,b,c, Headington OX3 7DQ

The FANC (Fanconi anemia) pathway: far beyond the protection of DNA replication

Filippo Rosselli

Audience: Members of the University only

Organisers: Amanda O'Neill

Mon 4 Mar 2019 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, MRC WIMM Seminar Room, Headington OX3 9DS

Cellular plasticity, cellular heterogeneity and single cell sequencing

Prof Xin Lu

Audience: Members of the University only

Organisers: Liz Cloke

Tue 5 Mar 2019 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Richard Doll Seminar: Life course economic evaluation of early years' policy and its impacts on health inequality

Professor Richard Cookson

Audience: Members of the University only

Organisers: Graham Bagley

Thu 7 Mar 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

Autophagy and metabolism in cell death and cancer’

Professor Kevin Ryan

Audience: Members of the University only

Organisers: Christina Woodward

Thu 7 Mar 2019 from 13:00 to 14:00

Medical Grand Rounds

Emergency Medicine / Clinical Biochemistry

Emergency Medicine: -- Clinical Biochemistry: -- Chair: Prof Hugh Watkins

Emergency Medicine: -- Clinical Biochemistry: -- Chair: Prof Hugh Watkins

Audience: Members of the University and NHS clinical staff.

Fri 8 Mar 2019 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Surgical Grand Rounds - Radiology

Dr Raman Uberoi

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 8 Mar 2019 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Drakesmith Group

Audience: Members of the University only

Organisers: Anne Farmer

Fri 8 Mar 2019 from 12:00 to 13:00

Health Economics Seminars

Title TBC

Dr Benjamin Craig, Associate Professor

Audience: Members of the University only

Organisers: HERC

Fri 8 Mar 2019 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Sympathetic Neuroimmunity for Obesity

Dr Ana Domingos

The brain controls adiposity via central and peripheral neural circuits. We used molecular genetic tools such as optogenetics to probe the connection between peripheral sympathetic neurons and adipocytes. Further, we found this neuro-adipose junction to drive lipolysis via norepinephrine (NE)... Read more

The brain controls adiposity via central and peripheral neural circuits. We used molecular genetic tools such as optogenetics to probe the connection between peripheral sympathetic neurons and adipocytes. Further, we found this neuro-adipose junction to drive lipolysis via norepinephrine (NE) signaling (1) and that the SNS is necessary and sufficient for fat mass reduction (1,2). As obesity is a chronic inflammatory state, we set to define neuroimmune mechanisms that link inflammation to SNS neurons (3). We report the discovery of Sympathetic neuron-Associated Macrophages (SAMs) that directly regulate the extracellular availability of norepinephrine (NE). We identified the molecular mechanism by which SAMs import and metabolize norepinephrine (NE). Abrogation of the mechanism for the uptake of NE by SAMs increases NE availability, which in turn promotes thermogenesis and browning, and long-term amelioration of obesity independently of food intake (3). These results suggested that blockade of NE uptake outside the brain is sufficient to promote weight loss role thus we chemically modified an amphetamine, which targets the NE transporter, such that it does not cross the BBB. The anti-obesity effect of this novel drug will be discussed.

Audience: Members of the University only

Fri 8 Mar 2019 from 13:00 to 14:00

NDM Seminar Series

Henry Wellcome Building of Cellular and Molecular Physiology, Seminar Rooms A & B, Roosevelt Drive OX3 7BN

Title TBC

Prof Jane McKeating, Dr Gail Carson

Audience: Members of the University only

Organisers: Kathryn Smith

Mon 11 Mar 2019 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, Meeting Rooms 71a,b,c, Headington OX3 7DQ

Blocking DNA replication before it starts: insights on CDC7 kinase inhibition by chemical genetics and genome editing approaches

Prof Corrado Santocanale

Audience: Members of the University only

Organisers: Amanda O'Neill

Tue 12 Mar 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Regulation of dormant hematopoietic stem cells

Dr Nina Cabezas-Wallscheid

Audience: Members of the University only

Organisers: Liz Rose

Wed 13 Mar 2019 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Dr Anna Pasetto

Audience: Members of the University only

Organisers: Anne Farmer

Thu 14 Mar 2019 from 13:00 to 14:00

Medical Grand Rounds

Combined Medical-Surgical Grand Round

Combined Medical-Surgical Grand Round Chair: Prof Chris Conlon

Combined Medical-Surgical Grand Round Chair: Prof Chris Conlon

Audience: Members of the University and NHS clinical staff.

Thu 14 Mar 2019 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Richard Doll Seminar: Examining public health workers' perceptions toward response expectations in disasters

Associate Professor Daniel Barnett

Audience: Members of the University only

Organisers: Graham Bagley

Fri 15 Mar 2019 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Cerundolo Group

Audience: Members of the University only

Organisers: Anne Farmer

Tue 19 Mar 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Exploring the role of RNA modifications in myeloid leukaemogenesis

Dr Konstantinos Tzelepis

Audience: Members of the University only

Organisers: Liz Rose

Wed 20 Mar 2019 from 13:30 to 14:30

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

“How to Write a Histone Code”

Professor David Shechter

Audience: Members of the University only

Thu 21 Mar 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

From Cancer Systems Biology to Precision medicine

Dr Marie-Laure Yaspo

Audience: Members of the University only

Organisers: Christina Woodward

Thu 21 Mar 2019 from 14:00 to 15:00

Experimental Medicine TGU Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, MRC Weatherall Institute of Molecular Medicine,Headington OX3 9DS, Headington OX3 9DS

'Unconventional' T Cells in the Skin

Dr Graham Ogg

Audience: Members of the University only

Organisers: Dr Carolina Arancibia

Tue 26 Mar 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

MHU Student Presentations

Audience: Members of the University only

Organisers: Liz Rose

Wed 27 Mar 2019 from 16:00 to 17:00

OPDC Seminar Series (DPAG)

Sherrington Library, off Parks Road OX1 3PT

LRRK2 Mediated Cellular Function from Vesicular Trafficking to Gene Expression

Professor Kirsten Harvey

My research has focused on two main aspects of neurobiology, the pathogenesis of Parkinson’s and trapping and accumulation of inhibitory receptors at synapses. In my laboratory, we employ cell biological, biochemistry and proteomic techniques in an effort to: i) discover how pathogenic mutations... Read more

My research has focused on two main aspects of neurobiology, the pathogenesis of Parkinson’s and trapping and accumulation of inhibitory receptors at synapses. In my laboratory, we employ cell biological, biochemistry and proteomic techniques in an effort to: i) discover how pathogenic mutations in PARK genes lead to neuronal death, ii) uncover new leads for genetic analysis, and iii) identify new therapeutic targets for disease modifying treatment. My current research focus is on the physiological and pathological role of the Parkinson’s protein LRRK2 in Wnt signalling and cytoskeletal function. In addition, I continue to research the role of proteins important for receptor clustering such as gephyrin and collybistin in inhibitory receptor clustering and intellectual disability.

Audience: Members of the University only

Organisers: Melanie Witt