Other Seminars

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Fri 1 Feb 2019 from 17:00 to 19:00

AfOx insaka - a gathering for sharing ideas and knowledge about Africa-focused research

St Cross College, Lecture Theatre, West Wing, St Giles OX1 3LZ

Mon 4 Feb 2019 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, Meeting Rooms 71a,b,c, Headington OX3 7DQ

Title TBC

Violeta Serra

Audience: Members of the University only

Organisers: Amanda O'Neill

Mon 4 Feb 2019 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, MRC WIMM Seminar Room, Headington OX3 9DS

Chromosome Replication: From Mechanism to Misregulation in Cancer

Prof John Diffley

Audience: Members of the University only

Organisers: Liz Cloke

Tue 5 Feb 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

Redox differences between the Heart and Tumour could provide a Selective Therapeutic Approach for Chemotherapy-Induced Cardiotoxicity

Dr Gopinath Sutendra

Audience: Members of the University only

Organisers: Christina Woodward

Wed 6 Feb 2019 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Cellular mechanics of B cell responses

Dr Pavel Tolar

Audience: Members of the University only

Organisers: Anne Farmer

Thu 7 Feb 2019 from 13:00 to 14:00

Medical Grand Rounds

Geratology / GU Medicine

Dr Emily Lord, Dr Huda Fadzillah

Geratology: -- GU Medicine: Dr Emily Lord and Dr Huda Fadzillah -- Chair: TBA

Geratology: -- GU Medicine: Dr Emily Lord and Dr Huda Fadzillah -- Chair: TBA

Audience: Members of the University and NHS clinical staff.

Thu 7 Feb 2019 from 16:30 to 18:30

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, John Radcliffe Main Building, George Pickering Education Centre Level 3 Academic Centre, Room 2B, Headington OX3 9DU

The Genetics of IBD-An update

Dr Carl Anderson

Audience: Members of the University only

Organisers: Professor Holm Uhlig

Mon 11 Feb 2019 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, MRC WIMM Seminar Room, Headington OX3 9DS

Sex chromosome functions in development and disease

Audience: Members of the University only

Organisers: Liz Cloke

Wed 13 Feb 2019 from 16:00 to 17:00

OPDC Seminar Series (DPAG)

Sherrington Library, off Parks Road OX1 3PT

Title TBC

Dr. Elisa Greggio

Dr. Elisa Greggio is a molecular physiologist in the Department of Biology at the University of Padova, Italy. RESEARCH INTERESTS: Genetic forms of dominant Parkinson's. Mitochondrial function, axonal transport and cellular pathways in Parkinson's. Biochemical properties of Leucine-rich repeat kinase 2 (LRRK2). Oxidative stress in Parkinson's.

Dr. Elisa Greggio is a molecular physiologist in the Department of Biology at the University of Padova, Italy. RESEARCH INTERESTS: Genetic forms of dominant Parkinson's. Mitochondrial function, axonal transport and cellular pathways in Parkinson's. Biochemical properties of Leucine-rich repeat kinase 2 (LRRK2). Oxidative stress in Parkinson's.

Audience: Members of the University only

Organisers: Melanie Witt

Thu 14 Feb 2019 from 13:00 to 14:00

Medical Grand Rounds

Infection/Microbiology / Renal

Infection/Microbiology: -- Renal: -- Chair: TBA

Infection/Microbiology: -- Renal: -- Chair: TBA

Audience: Members of the University and NHS clinical staff.

Fri 15 Feb 2019 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Surgical Grand Rounds - Upper GI

Mr Nick Maynard

Audience: Members of the University only

Organisers: Tarryn Ching

Mon 18 Feb 2019 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, Meeting Rooms 71a,b,c, Headington OX3 7DQ

Mechanisms linking DNA replication to cell fate determination under normal and stressful conditions

Dr Vincenzo Costanzo

Audience: Members of the University only

Organisers: Amanda O'Neill

Tue 19 Feb 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Stem cells and differentiation in myelodysplastic syndromes

Professor Eva Hellstrom Lindberg

Audience: Members of the University only

Organisers: Liz Rose

Thu 21 Feb 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

Engineering the cellular microenvironment with functional and living materials

Professor Manuel Salmeron-Sanchez

Audience: Members of the University only

Organisers: Christina Woodward

Thu 21 Feb 2019 from 13:00 to 14:00

Medical Grand Rounds

Respiratory / Gastroenterology

Dr Anthony Croft, Dr Satish Keshav

Respiratory: -- Gastroenterology: Dr Anthony Croft and Dr Satish Keshav -- Chair: TBA

Respiratory: -- Gastroenterology: Dr Anthony Croft and Dr Satish Keshav -- Chair: TBA

Audience: Members of the University and NHS clinical staff.

Mon 25 Feb 2019 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Utilising the totality of mutagenesis for clinical purposes

Dr Serena Nik-Zainal

A cancer genome carries the historic mutagenic activity that has occurred throughout the development of a tumour1. While driver mutations were the main focus of cancer research for a long time, passenger mutational signatures - the imprints of DNA damage and DNA repair processes that have been... Read more

A cancer genome carries the historic mutagenic activity that has occurred throughout the development of a tumour1. While driver mutations were the main focus of cancer research for a long time, passenger mutational signatures - the imprints of DNA damage and DNA repair processes that have been operative during tumorigenesis - are also biologically informative1,2. In this lecture, I provide a synopsis of this concept, describe the insights that we have gained through combinations of computational analysis3,4 and experiments in cell-based systems5, and showcase how we have developed the concept into applications that we hope to translate into clinical utility in the near future3,4. I describe our efforts in a population-derived cohort as well as in individual patients, emphasizing the need for us to be more precise in analyses and interpretation in human cancer genomics. References: 1. Helleday T, Eshtad S, Nik-Zainal S. Mechanisms underlying mutational signatures in human cancers.Nat Rev Genet. 2014 Sep;15(9):585-98. doi: 10.1038/nrg3729. Epub 2014 Jul 1. Review. PubMed PMID: 24981601; PubMed Central PMCID: PMC6044419. 2. Alexandrov LB, Nik-Zainal S, et al. Signatures of mutational processes in human cancer. Nature. 2013 Aug 22;500(7463):415-21. doi: 10.1038/nature12477. Epub 2013 Aug 14. Erratum in: Nature. 2013 Oct 10;502(7470):258. Imielinsk, Marcin [corrected to Imielinski, Marcin]. PubMed PMID: 23945592; PubMed Central PMCID: PMC3776390. 3. Nik-Zainal S, Davies H, et al. Landscape of somatic mutations in 560 breast cancer whole-genome sequences. Nature. 2016 Jun 2;534(7605):47-54. doi: 10.1038/nature17676. Epub 2016 May 2. PubMed PMID: 27135926; PubMed Central PMCID: PMC4910866. 4. Davies H, Glodzik D, et al. and Nik-Zainal S. HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. Nat Med. 2017 Apr;23(4):517-525. doi: 10.1038/nm.4292. Epub 2017 Mar 13. PubMed PMID: 28288110; PubMed Central PMCID: PMC5833945. 5. Zou X, Owusu M, Harris R, Jackson SP, Loizou JI, Nik-Zainal S. Validating the concept of mutational signatures with isogenic cell models. Nat Commun. 2018 May 1;9(1):1744. doi: 10.1038/s41467-018-04052-8. PubMed PMID: 29717121; PubMed Central PMCID: PMC5931590.

Audience: Members of the University only

Organisers: Liz Cloke

Tue 26 Feb 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Title TBC

Dr Antti Lignell

Audience: Members of the University only

Organisers: Liz Rose

Tue 26 Feb 2019 from 14:30 to 15:30

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

NPEU Seminar: Using qualitative research to shape, inform, and implement global guidelines in maternity care.

Prof. Soo Downe OBE

Audience: Members of the University only

Organisers: Graham Bagley

Wed 27 Feb 2019 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Dr Mikhail Shugay

Audience: Members of the University only

Organisers: Anne Farmer

Thu 28 Feb 2019 from 13:00 to 14:00

Medical Grand Rounds

Palliative Care / Neurology

Dr Michele Hu

Palliative Care: -- Neurology: Dr Michele Hu -- Chair: TBA

Palliative Care: -- Neurology: Dr Michele Hu -- Chair: TBA

Audience: Members of the University and NHS clinical staff.