Other Seminars

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Mon 2 Dec 2019 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

The “dark side” of the genome: how histone H3K9 methylation stabilizes repeats

Prof Susan Gasser

Audience: Members of the University only

Organisers: Liz Cloke

Tue 3 Dec 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Dissecting erythropoiesis in Diamond-Blackfan anaemia at single-cell resolution

Dr Deena Iskander

Audience: Members of the University only

Organisers: Liz Rose

Tue 3 Dec 2019 from 13:00 to 14:00

Population Health Seminars

Big Data Institute, Seminar rooms, Old Road Campus OX3 7LF

Richard Doll Seminar - Clinical trials: now and in the future

Professor Isla MacKenzie

Audience: Members of the University only

Organisers: Graham Bagley

Thu 5 Dec 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, NDMRB (TDI) seminar room, Headington OX3 7FZ

Dual Pathogen and Cancer Detection Using Cell-free DNA in Body Fluids

Dr Wei Gu

Wei Gu, MD, PhD, is a board-certified pathologist at UCSF. His research focuses on minimally invasive diagnostics using cell-free DNA/RNA with an emphasis on infectious disease, oncology, and prenatal diagnostics. He received his Bioengineering MD/PhD from Stanford University working with... Read more

Wei Gu, MD, PhD, is a board-certified pathologist at UCSF. His research focuses on minimally invasive diagnostics using cell-free DNA/RNA with an emphasis on infectious disease, oncology, and prenatal diagnostics. He received his Bioengineering MD/PhD from Stanford University working with Dr. Stephen Quake on cell-free prenatal (NIPT) and cancer diagnostics. Dr. Gu completed his Clinical Pathology residency and Molecular Genetic Pathology fellowship at UCSF.

Audience: Members of the University only

Organisers: Alexandra Ward

Thu 5 Dec 2019 from 13:00 to 14:00

Medical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Jenner Institute / Silver Star

Prof Adrian Hill

Jenner Institute: "Malaria Vaccines – quite a challenge", Prof Adrian Hill -- Silver Star: Chair: Prof Richard Cornall

Jenner Institute: "Malaria Vaccines – quite a challenge", Prof Adrian Hill -- Silver Star: Chair: Prof Richard Cornall

Audience: Members of the University and NHS clinical staff.

Fri 6 Dec 2019 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Surgical Grand Rounds - Perioperative medicine

Dr Shvaita Ralhan

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 6 Dec 2019 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Irani Group

Audience: Members of the University only

Organisers: Anne Farmer

Fri 6 Dec 2019 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Clonal lineage determines the direct conversion of thalamic astrocytes into subtype-specific thalamocortical neurons

Professor Guillermina López-Bendito

Forced expression of defined transcription factors leads to the direct conversion of various cell types into induced neurons (iNs). Specifically, successful reprogramming of resident brain astrocytes in vitro as well as in vivo represents a great advantage for the generation of neurons and derived... Read more

Forced expression of defined transcription factors leads to the direct conversion of various cell types into induced neurons (iNs). Specifically, successful reprogramming of resident brain astrocytes in vitro as well as in vivo represents a great advantage for the generation of neurons and derived circuits. However, whether astrocytes from distinct brain regions might show a reprogramming specificity towards a unique iN type remains largely unknown. Here, we use direct reprogramming of thalamic astrocytes by Neurog2 to generate specific excitatory sensory-modality thalamocortical neurons. Moreover, we show that the origin, but not the environment of the astrocytes determines the fate of the iNs after direct reprogramming. Indeed, clonal analysis in the thalamus shows that astrocytes from the distinct thalamic nuclei are clonally related determining the specificity of the iNs generated from those astrocytes. We also found that the potential of the same transcription factor to reprogram nuclei-specific thalamic astrocytes into precise subsets of thalamocortical neurons depends on particular epigenetic modifications. In sum, our study provides novel insights into the mechanisms that control the specification of thalamic neurons and importantly those that are required for direct programming of sensory neurons. Generation of specific sensory brain circuits might be an approach for future rehabilitation strategies.

Audience: Members of the University only

Organisers: Professor Zoltan Molnar

Mon 9 Dec 2019 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7FY

T cell immunity begins with TCR allosteric activation

Professor Oreste Acuto

T cell-dependent immunity commences with T-cell antigen receptor (TCR-CD3) signalling. TCR-CD3 features unique ligand recognition, signalling modalities and convoluted quaternary structure, diverging considerably from “classic”, evolutionary ancient membrane receptors of simpler molecular... Read more

T cell-dependent immunity commences with T-cell antigen receptor (TCR-CD3) signalling. TCR-CD3 features unique ligand recognition, signalling modalities and convoluted quaternary structure, diverging considerably from “classic”, evolutionary ancient membrane receptors of simpler molecular design and univocal relationship to ligands. TCR-CD3 recognises with exceptional sensorial and discriminatory ability antigens of varying structure, quantity and detection context. Given such a complexity, it is perhaps unsurprising that controversy exists on how TCR-CD3 works. I will report new data suggesting an allosteric mechanism by which TCR-CD3 transmits signals across the plasma membrane that should improve our understanding of how T cell activation begins.

Audience: Public

Organisers: Jennifer Pope

Tue 10 Dec 2019 from 14:00 to 15:00

Population Health Seminars

Big Data Institute, Seminar rooms, Old Road Campus OX3 7LF

Richard Doll Seminar - Global diabetes epidemiology: past, present and future

Professor Sarah Wild

Audience: Members of the University only

Organisers: Graham Bagley

Tue 10 Dec 2019 from 15:00 to 16:00

WHG Seminars

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

From multi-omic discoveries to clinical insights

Dr Claudia Langenberg

Recent technological advances now enable in-depth assessment of blood based 'omic' markers at scale and can provide important insights into the aetiology of metabolic and other diseases. Existing studies are limited by their design, size, analytical strategy and single disease focus. We combine... Read more

Recent technological advances now enable in-depth assessment of blood based 'omic' markers at scale and can provide important insights into the aetiology of metabolic and other diseases. Existing studies are limited by their design, size, analytical strategy and single disease focus. We combine large-scale genomic with metabolomic and proteomic data to define the genetic architecture of thousands of ‘omic’ traits. We integrate data from different platforms and studies to maximise power for the identification of genetic variants associated with life-long differences in metabolite and protein levels and enable investigation of their relevance for disease aetiology and prediction, with a specific focus on type 2 diabetes and related traits.

Audience: Members of the University only

Organisers: Isabel Schmidt

Thu 12 Dec 2019 from 13:00 to 14:00

Medical Grand Rounds

Combined Medical-Surgical Grand Round

Combined Medical-Surgical Grand Round: Chair: TBA

Combined Medical-Surgical Grand Round: Chair: TBA

Audience: Members of the University and NHS clinical staff.

Mon 16 Dec 2019 from 11:00 to 12:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Mon 16 Dec 2019 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Precision and Plasticity in Animal Transcription

Assoc Prof Angela DePace

Audience: Members of the University only

Organisers: Liz Cloke

Tue 17 Dec 2019 from 10:30 to 11:30

Population Health Seminars

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

NPEU Seminar - The genetics of reproductive behaviour

Prof. Melinda Mills

Audience: Members of the University only

Organisers: Graham Bagley

Tue 17 Dec 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Re-configuration of chromatin structure during the mitosis-G1 phase transition

Dr Gerd Blobel

Audience: Members of the University only

Organisers: Liz Rose