Other Seminars

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Mon 16 Dec 2019 from 11:00 to 12:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Investigating the mechanisms and elements responsible for regulatory domain formation during gene regulation

Caroline Harrold

Audience: Members of the University only

Organisers: Liz Rose

VIVA SEMINAR

Mon 16 Dec 2019 from 12:00 to 13:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Precision and Plasticity in Animal Transcription

Assoc Prof Angela DePace

Audience: Members of the University only

Organisers: Liz Cloke

Mon 16 Dec 2019 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7FY

‘Novel facets of the stromal immune cell interactions conferring immune protection in the serous cavities.’ 

Dr Cecile Benezech

Fat-associated lymphoid clusters (FALCs) are small immune structures found in certain visceral adipose tissues such as the omentum and the pericardium, which provide an important first layer of defence during infection. Our recent work show that the function of FALCs is underlaid by specialised... Read more

Fat-associated lymphoid clusters (FALCs) are small immune structures found in certain visceral adipose tissues such as the omentum and the pericardium, which provide an important first layer of defence during infection. Our recent work show that the function of FALCs is underlaid by specialised mesothelial stromal cells which cover the surface of FALCs. During peritonitis, they drive the recruitment and formation of neutrophil aggregates which mediate the capture of peritoneal contaminants and limit systemic propagation. In addition, I will discuss recent data investigating the role of Tim4+ adipose tissue macrophages in the control of lipid metabolism. Biography Cécile Bénézech did her PhD in Nantes (France) investigating the anti-tumour activity of human  T cells. She then moved to Birmingham (UK) in the laboratory of Jorge Caamano to study the role of TNF receptors in the development of lymphoid tissue. During her time in the lab, she discovered that lymph nodes and adipose tissue are developmentally related and that during embryonic development, adipocyte precursor cells give rise to the stroma of the lymph nodes. This led her to investigate other lymphoid structures characteristics of certain fat depots and to demonstrate the importance of Fat-associated lymphoid clusters in immunity. In 2013, she was awarded a Chancellor’s Fellowship to set up her own lab in the Centre for Cardiovascular Sciences in Edinburgh. Her lab is investigating the role of visceral fat depot in the protection of serous cavities and how adipose tissue immune cells help maintain metabolic health.

Audience: Members of the University only

Organisers: Jo Silva

Mon 16 Dec 2019 from 13:30 to 14:15

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Human fetal B-lymphopoiesis and acute lymphoblastic leukaemia: the impact of trisomy 21

Ms Sorcha O'Byrne

Audience: Members of the University only

Organisers: Fiona Lambert

VIVA SEMINAR

Tue 17 Dec 2019 from 10:30 to 11:30

Population Health Seminars

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

NPEU Seminar - The genetics of reproductive behaviour

Prof. Melinda Mills

Audience: Members of the University only

Organisers: Graham Bagley

Tue 17 Dec 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Re-configuration of chromatin structure during the mitosis-G1 phase transition

Dr Gerd Blobel

Audience: Members of the University only

Organisers: Liz Rose