Other Seminars

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Tue 2 Apr 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Repression of gene expression by Groucho/TLE family proteins during development and disease

Dr Barbara Jennings

Audience: Members of the University only

Organisers: Liz Rose

Wed 3 Apr 2019 from 11:00 to 12:30

Ethox Centre and Wellcome Centre for Ethics and Humanities

Big Data Institute, Seminar Room 0, Old Road Campus OX3 7LF

Ethox and WEH Seminar: Bringing Bioethics into Play: Digital Games as an Empirical Tool to Investigate Moral Choices

Gabriela Pavarini

Digital games are already part of everyday life for about 2 billion people worldwide, and their popularity has been increasing steadily in recent years. Games are emotionally engaging, interactive, and allow for a myriad of scenarios and ramifications. Despite these advantages, bioethics has yet to... Read more

Digital games are already part of everyday life for about 2 billion people worldwide, and their popularity has been increasing steadily in recent years. Games are emotionally engaging, interactive, and allow for a myriad of scenarios and ramifications. Despite these advantages, bioethics has yet to embrace this exceptional resource. This talk presents a theoretical rationale to motivate empirical bioethicists to use games as an empirical tool. I will discuss how games fit into the current methodological landscape in the field, and what advantages they offer in comparison to traditional methods, including their potential for high scalability and greater emotional and contextual grounding. I will close with an example of a digital role-playing scenario, developed in collaboration with the Neuroscience, Ethics and Society Young People’s Advisory Group, to investigate young people’s values and preferences in relation to predictive testing in mental health.

Audience: Members of the University only

Organisers: Christa Henrichs

Thu 4 Apr 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

* CANCELLED * RNA editors and DNA mutators: diverse biological roles for a tight-knit family of enzymes

Dr Nina Papavassiliou

Audience: Members of the University only

Organisers: Christina Woodward

Thu 4 Apr 2019 from 13:00 to 14:00

Population Health Seminars

NDM Building, Seminar Room, Headington OX3 7FZ

Thu 4 Apr 2019 from 16:30 to 18:30

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, John Radcliffe Main Building, George Pickering Education Centre Level 3 Academic Centre, Room 2B, Headington OX3 9DU

Lymphocyte activation gene (LAG)-3 is associated with mucosal inflammation and disease activity in ulcerative colitis

Dr Stephanie Slevin

Audience: Members of the University only

Organisers: Professor Holm Uhlig

Fri 5 Apr 2019 from 09:15 to 10:15

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

* CANCELLED * Regulation of endogenous retroviruses

Prof Akiko Iwasaki

Audience: Members of the University only

Organisers: Liz Cloke

Fri 5 Apr 2019 from 10:30 to 11:30

Single Cell Seminars at WHG

Dissecting and directing cerebellar ontogenesis – towards an organoid model for understanding disease of the cerebellum

Samuel Nayler

#10X #NeuronalDevelopment #Cell-hashing

#10X #NeuronalDevelopment #Cell-hashing

Audience: Members of the University only

Fri 5 Apr 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, NDMRB TDi seminar room, Headington OX3 7FZ

“NOD-like receptors: From pathogen recognition to surveillance of cellular homeostasis perturbation”

Dr. Gang Pei

Audience: Members of the University only

Organisers: Alexandra Ward

Fri 5 Apr 2019 from 13:00 to 14:00

NDM Seminar Series

Henry Wellcome Building of Cellular and Molecular Physiology, Seminar Rooms A & B, Roosevelt Drive OX3 7BN

Selective Targeting of Transcriptional Scaffolding & Investigating Shared Immunopathology of immune-mediated diseases

Dr. Panagis Filippakopoulos, Dr Calliope A Dendrou

Audience: Members of the University only

Organisers: Kathryn Smith

Mon 8 Apr 2019 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Theatre, Headington OX3 7LF

Innate Immune Control Of Thymus Regeneration

Prof Graham Anderson

Steady-state production of naïve T-cells depends upon T-cell development in the thymus. Multiple scenarios can influence thymus function, including ‘natural’ (pregnancy, ageing) and ‘pathological’ processes (infection, stress, -irradiation). While the thymus is very sensitive to... Read more

Steady-state production of naïve T-cells depends upon T-cell development in the thymus. Multiple scenarios can influence thymus function, including ‘natural’ (pregnancy, ageing) and ‘pathological’ processes (infection, stress, -irradiation). While the thymus is very sensitive to these stimuli, it possesses effective endogenous regenerative properties that restore T-cell production. In the absence of such recovery, T-cell development and the incorporation of new naïve T-cells into the peripheral pool is slow. Thus, thymus regeneration represents an important process in restoring homeostasis in the immune system. Here, we identify eosinophils as new regulators of thymus regeneration, and present data on the cellular and molecular mechanisms by which they influence thymus function. ---- Graham gained a BSc in Anatomical Studies from the University of Birmingham in 1990. He studied for a PhD in Immunology as a Wellcome Prize PhD student, supervised by Eric Jenkinson and John Owen. His PhD studies developed the reaggregate thymus organ culture system. Since then he has continued his career in Birmingham, firstly as a Wellcome Prize Fellow until 1994, and since then as member of academic staff. He was appointed to a Chair in T-Lymphocyte Biology in 1995, and then Professor of Experimental Immunology in 2016. Throughout his career he has been been interested in how thymic stromal cells guide the development and selection of self-tolerant T-cells in the thymus. Graham is currently a member of the Wellcome Trust Expert Review Group ‘Immune System In Health and Disease’, and a Scientific Advisory Board member for activities in The Universities of Glasgow and Oxford, and the KG Jebsen Centre for Autoimmune Disorders, in Norway.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Wed 10 Apr 2019 from 11:30 to 12:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar room, Headington OX3 9DS

Democratising Live-Cell Compatible High-Speed Super-Resolution Microscopy

Professor Ricardo Henriques

Audience: Members of the University only

Organisers: Anne Farmer

Thu 11 Apr 2019 from 13:30 to 14:30

ARUK Oxford Drug Discovery Institute Seminar Series

NDM Building, Seminar room, Headington OX3 7FZ

Discovery and characterisation of new lipid mediators of innate immunity generated by circulating blood cells

Professor Valerie O'Donnell

Audience: Members of the University only

Organisers: Kate Humphrey

Fri 12 Apr 2019 from 10:30 to 11:30

Single Cell Seminars at WHG

Wellcome Trust Centre for Human Genetics, Room K, Headington OX3 7BN

Title TBC

#SingleCellChemicalDemultiplexing

#SingleCellChemicalDemultiplexing

Audience: Members of the University only

Organisers: Fabiola Curion

Tue 16 Apr 2019 from 12:00 to 13:00

Department of Oncology

Old Road Campus Research Building, Meeting Rooms 71a,b,c on the ground floor, Headington OX3 7DQ

The Triple Win: how the UK can achieve personalised medicine, a growing life science sector, and an affordable NHS

Lord James O'Shaughnessy

Audience: Members of the University only

Organisers: Jade Schneiders

Tue 16 Apr 2019 from 16:00 to 17:00

OPDC Seminar Series (DPAG)

Sherrington Library, off Parks Road OX1 3PT

Pathway to Parkinson’s Disease: A Tale of Two Genes

Darren Moore

The Moore Laboratory investigates the molecular pathophysiology of Parkinson’s. The majority of Parkinson’s cases occur in a sporadic manner although 5 to 10 percent of cases are inherited, with causative mutations identified in at least eight genes. The Moore Laboratory studies the normal... Read more

The Moore Laboratory investigates the molecular pathophysiology of Parkinson’s. The majority of Parkinson’s cases occur in a sporadic manner although 5 to 10 percent of cases are inherited, with causative mutations identified in at least eight genes. The Moore Laboratory studies the normal biology and pathobiology of gene products that cause inherited Parkinson’s, including the common leucine-rich repeat kinase 2 (LRRK2, PARK8), the retromer component VPS35 (PARK17), the E3 ubiquitin ligase parkin (PARK2), and the lysosomal P5-type ATPase ATP13A2 (PARK9).

Audience: Members of the University only

Organisers: Melanie Witt

Wed 17 Apr 2019 from 16:00 to 17:00

CNCB Seminar Series

Oxford Martin School, Oxford Martin School, 34 Broad Street, 34 Broad Street OX1 3BD

Nearly Isotropic 3D-Imaging of Mouse Brains, Fly Brains and Human Tumors with Light Sheets Beyond the Diffraction Light - Please note new date and time.

Hans-Ulrich Dodt

Optics involving extremely long, thin sheets of light and a vastly increased Rayleigh range (achieved by breaking the diffraction limit of light sheets of low numerical aperture) allow an elegant application of ultramicroscopy to large samples, such as whole mouse brains or Drosophila. Due to the... Read more

Optics involving extremely long, thin sheets of light and a vastly increased Rayleigh range (achieved by breaking the diffraction limit of light sheets of low numerical aperture) allow an elegant application of ultramicroscopy to large samples, such as whole mouse brains or Drosophila. Due to the extremely low divergence of the light sheets, brains can be reconstructed from a single stack of optical sections with nearly isotropic resolution that reaches the single-spine level at higher magnification. Ultramicroscopy can be applied to samples of ever-increasing size. Large pieces of human tumors that have been cleared and stained by a new superfast clearing procedure can be imaged intraoperatively in three dimensions. Optically identified malignancies were subsequently confirmed by standard histological sectioning. We predict that ultramicroscopy of cleared tumors will play an increasingly important role in pathological diagnostics.

Audience: Members of the University only

Organisers: Fiona Woods

Thu 18 Apr 2019 from 14:30 to 15:30

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, John Radcliffe Main Building, Lecture Theatre 1, Academic Centre, level 3, Headington OX3 9DU

Current Clinical Trials in IBD

Professor Simon Travis

Audience: Members of the University only

Organisers: Dr Carolina Arancibia

Thu 18 Apr 2019 from 15:30 to 16:30

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, John Radcliffe Main Building, Lecture Theatre 1, Academic Centre, level 3, Headington OX3 9DU

A 21st century toolkit for clinical pharmacology: Plans for the Centre for Clinical Therapeutics

Professor Duncan Richards

Audience: Members of the University only

Organisers: Dr Carolina Arancibia

Tue 23 Apr 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, seminar room, Headington OX3 9DS

Functional dissection of the 3D genome

Elzo de Wit

Audience: Members of the University only

Organisers: Liz Rose

Thu 25 Apr 2019 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

Title TBC

Dr Christian Frezza

Audience: Members of the University only

Organisers: Christina Woodward

Thu 25 Apr 2019 from 13:00 to 14:00

Medical Grand Rounds

Infection/Microbiology / Acute General Medicine Firm D

Infection/Microbiology: -- Acute General Medicine Firm D: -- Chair: TBA

Infection/Microbiology: -- Acute General Medicine Firm D: -- Chair: TBA

Audience: Members of the University and NHS clinical staff.

Mon 29 Apr 2019 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Neurodegeneration: mechanism to medicines

Prof Giovanna Mallucci

Audience: Members of the University only

Organisers: Liz Cloke

Tue 30 Apr 2019 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

MHU Student Presentations

Audience: Members of the University only

Organisers: Liz Rose