Other Seminars

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Thu 1 Nov 2018 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

The role of post-transcriptional regulation in neural stem cells and synaptic plasticity

Professor Ilan Davis

During learning, repetitive neuronal activity, or lack of it, causes strengthening or weakening, respectively, of specific synaptic connections between axons and dendrites. This process of remodelling synapses is known as synaptic plasticity and forms the cellular and molecular basis of memory and... Read more

During learning, repetitive neuronal activity, or lack of it, causes strengthening or weakening, respectively, of specific synaptic connections between axons and dendrites. This process of remodelling synapses is known as synaptic plasticity and forms the cellular and molecular basis of memory and learning. It has been known for over 50 years that long-term plasticity requires new protein synthesis immediately after the learning stimulus. Clearly, a rapid local translational response must depend upon the availability of specific RNAs at the synapse. However, how most mRNAs are directed to the synapse is poorly understood, as is the mechanism by which synaptic RNA abundance is regulated. We have been systematically characterising the distributions of several hundred randomly chosen mRNAs as well as their rates of synthesis and decay near synapses using the powerful Drosophila neuromuscular model junction (NMJ) system. We find that approximately 10% of individual types of RNA present in neurones are located at the tips of synapses and in some cases we have shown that they encode proteins required for synaptic plasticity. Our genome wide analysis of RNA stability has identified a wide variation in cytoplasmic stability and in some cases we show that regulating stability determines the distribution of RNA across different cell types in the nervous system.

Audience: Members of the University only

Organisers: Christina Woodward

Thu 1 Nov 2018 from 13:00 to 14:00

Medical Grand Rounds

Dermatology / Medical Director's Office

Dermatology: -- Medical Director's Office: -- Chair: TBA

Dermatology: -- Medical Director's Office: -- Chair: TBA

Audience: Members of the University and NHS clinical staff.

Thu 1 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

UBVO Seminar: Revealing later life vulnerabilities through the study of food practices

Wendy Wills

Audience: Members of the University only

Organisers: Graham Bagley

Thu 1 Nov 2018 from 13:30 to 14:30

MRC HIU Wednesday Seminar Series

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Epithelial damage and tissue gd T cells promote a unique tumour-protective IgE response

Dr Greg H Crawford

Audience: Members of the University only

Organisers: Anne Farmer

Thu 1 Nov 2018 from 16:30 to 18:30

Experimental Medicine TGU Seminars

John Radcliffe Hospital - Main Building, John Radcliffe Main Building, George Pickering Education Centre Level 3 Academic Centre, Room 2B, Headington OX3 9DU

Metabolomics for IBD - are the answers in the blood?

Dr Alissa Walsh, Fay Probert

Audience: Members of the University only

Organisers: Professor Holm Uhlig

Fri 2 Nov 2018 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Surgical Grand Rounds - Breast surgery

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 2 Nov 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

MAITs at work: tales from down under

Prof. Paul Klenerman, Dr Timothy Hinks, Dr Sarah Sasson

Audience: Members of the University only

Organisers: Anne Farmer

Fri 2 Nov 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Library, off Parks Road OX1 3PT

Acylcarnitines - From Metabolism to Heart Function: A Focus on Their Role in Human Heart Failure

Dr Christine Des Rosier

There has been a resurgence of interest for the field of cardiac metabolism catalysed by the increased need for new therapeutic targets for patients with heart failure. Traditionally, the focus of research in this area has been on the impact of substrate selection – carbohydrates vs. fatty acids... Read more

There has been a resurgence of interest for the field of cardiac metabolism catalysed by the increased need for new therapeutic targets for patients with heart failure. Traditionally, the focus of research in this area has been on the impact of substrate selection – carbohydrates vs. fatty acids - for mitochondrial oxidative energy metabolism. The use of recently emerging metabolomic technologies - which aim at systematically measure all low-molecular weight compounds within a biological system - has provided some novel insight into the global metabolic perturbations prevailing in several cardiovascular diseases. Acylcarnitines (ACs) are among metabolites that have been the focus of many recent metabolomics-based studies, particularly in human heart failure. Profiling of circulating ACs has commonly been used for diagnosis of inborn errors of metabolism, particularly mitochondrial fatty acid oxidation (FA) defects. Beyond being proxies of fatty acid metabolic dysregulation, ACs - primarily long-chain ACs (LCACs) – are, however, increasingly being recognized as “actors”, modulating cell functions, as well as being linked to adverse cardiac events such as arrhythmias. This presentation aims to provide an overview of metabolic pathways generating ACs and of studies reporting elevated circulating levels of ACs, particularly LCACs, in human heart failure. It will also discuss proposed molecular mechanisms for the potential adverse effects of LCACs on cardiac function.

Audience: Members of the University only

Fri 2 Nov 2018 from 13:00 to 14:00

WHG Seminars

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

DNA repair mechanisms required for meiotic progression involving SWS1-SWSAP1 and BRCA2

Dr Carla Abreu

Abstract: During meiotic recombination, homology search and DNA-strand invasion ensure faithful homolog pairing and segregation, to avoid the formation of aneuploidy gametes. These central meiotic steps are catalyzed by two highly conserved recombinases, RAD51 and DMC1, which are assisted by... Read more

Abstract: During meiotic recombination, homology search and DNA-strand invasion ensure faithful homolog pairing and segregation, to avoid the formation of aneuploidy gametes. These central meiotic steps are catalyzed by two highly conserved recombinases, RAD51 and DMC1, which are assisted by mediator proteins such as BRCA2. RAD51 paralogs are another class of mediator proteins that have been implicated in homologous recombination, but their role in meiosis is poorly understood. I will present our novel findings uncovering a critical role for the recently identified RAD51 paralog complex, SWS1-SWSAP1, in the early steps of mouse meiotic recombination. In addition, I will show data supporting that this complex has overlapping functions with BRCA2, regulating meiotic RAD51/DMC1 recombination intermediates. Finally, I will present evidence of a switch to a mitotic-like recombination pathway at late meiotic stages that ensures the timely repair of double-stranded breaks before homologs segregate. Bio: Carla did her PhD work in Prof. Noel Lowndes lab at the National University of Ireland Galway. Her dissertation focused on the interplay between cell cycle regulation by the cyclin-dependent kinases and the activation of the DNA damage signaling pathway. Carla then joined the lab of Professor Maria Jasin at the Memorial Sloan Kettering Cancer Center in USA. As a postdoctoral fellow, she investigated the homologous recombination proteins that regulate the activity of the repair recombinases RAD51 and DMC1, focusing on the functions of BRCA2, RAD51 paralogs and RAD54. Carla is now transitioning to the IBMC/i3S in Portugal where she will start her own line of research.

Audience: Members of the University only

Organisers: Isabel Schmidt

Mon 5 Nov 2018 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, Meeting Rooms 71a,b,c, Headington OX3 7DQ

FAN1: a Fanconi anaemia (FA) protein but not a FA gene

Professor Josef Jiricny

Audience: Members of the University only

Mon 5 Nov 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Theatre, Headington OX3 7LF

Target identification for host directed therapy in leishmaniasis

Prof Paul Kaye

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Mon 5 Nov 2018 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

The Genomic Epidemiology of Emerging Viruses: Disease X, Yellow Fever, and Zika

Prof Oliver Pybus

Audience: Members of the University only

Organisers: Liz Cloke

Tue 6 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Wed 7 Nov 2018 from 10:30 to 11:30

Nuffield Department of Primary Care Health Sciences - Department research seminars

St Luke's Chapel, Woodstock Road OX2 6GG

Using the UK Biobank Study for biomedical research

Dr Carmen Piernas

The UK Biobank study has recruited 500,000 volunteers from all around the UK aged 40-69 at enrolment. This age group is being studied because it involves people at risk over the next few decades of developing a wide range of important diseases (including cancer, heart disease, stroke, diabetes,... Read more

The UK Biobank study has recruited 500,000 volunteers from all around the UK aged 40-69 at enrolment. This age group is being studied because it involves people at risk over the next few decades of developing a wide range of important diseases (including cancer, heart disease, stroke, diabetes, dementia). The purpose of this talk is to provide an introduction to this resource for health research and guidance on how to access and handle this data. I will also show preliminary results from current studies we are doing within the Health Behaviours team in the Nuffield Department of Primary Care Health Sciences.

Audience: Members of the University only

Organisers: Dr Jenny Hirst

Wed 7 Nov 2018 from 11:00 to 12:30

Ethox Centre and Wellcome Centre for Ethics and Humanities

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

Ethox and WEH Seminar: The Embassy of Good Science: A European Initiative to strengthen research integrity and research ethics

Dr Natalie Evans

Audience: Members of the University only

Organisers: Christa Henrichs

Thu 8 Nov 2018 from 13:00 to 14:00

Strubi seminars

Wellcome Trust Centre for Human Genetics, Meeting room A , Headington OX3 7BN

Bioinformatics and CryoEM

Dr Jon Agirre

Abstract The introduction of intuitive graphical software has enabled structural biologists who are not experts in crystallography to build complete protein or nucleic acid models rapidly. In contrast, carbohydrates are in a completely different situation: scant automation exists, and users... Read more

Abstract The introduction of intuitive graphical software has enabled structural biologists who are not experts in crystallography to build complete protein or nucleic acid models rapidly. In contrast, carbohydrates are in a completely different situation: scant automation exists, and users building models manually frequently trip over legacy issues such as incorrect dictionaries or non-standard atom naming, which evidence a historical lack of methodological support for carbohydrates. Sugars are stereochemically complex and, as pyranose rings, have clear conformational preferences. And despite this, all refinement programs may produce high-energy conformations at medium to low resolution, without any support from the electron density; this problem renders the affected structures unusable in glyco-chemical terms. Bringing structural glycobiology up to ‘protein standards’ is thus requiring a total methodological overhaul. Time is of the essence, as the community is steadily increasing the production rate of glycoproteins, and electron cryo- microscopy has just started to image them in precisely that resolution range where crystallographic methods falter most. In this talk, I will introduce our latest methodological developments, designed to streamline and automate hitherto error-prone processes, effectively aiding crystallographers and electron microscopists alike in producing correct atomic models with confidence. Some references in chronological order - Agirre, J., Davies, G., Wilson, K., & Cowtan, K. (2015). Carbohydrate anomalies in the PDB. Nature chemical biology, 11(5), 303. - Agirre, J., Iglesias-Fernández, J., Rovira, C., Davies, G. J., Wilson, K. S., & Cowtan, K. D. (2015). Privateer: software for the conformational validation of carbohydrate structures. Nature Structural and Molecular Biology, 22(11), 833. - Hudson, K. L., Bartlett, G. J., Diehl, R. C., Agirre, J., Gallagher, T., Kiessling, L. L., & Woolfson, D. N. (2015). Carbohydrate–aromatic interactions in proteins. Journal of the American Chemical Society, 137(48), 15152-15160. - Agirre, J., Davies, G. J., Wilson, K. S., & Cowtan, K. D. (2017). Carbohydrate structure: the rocky road to automation. Current opinion in structural biology, 44, 39-47. - McNicholas, S., & Agirre, J. (2017). Glycoblocks: a schematic three-dimensional representation for glycans and their interactions. Acta Crystallographica Section D: Structural Biology, 73(2), 187-194. - Agirre, J. (2017). Strategies for carbohydrate model building, refinement and validation. Acta Crystallographica Section D, 73(2), 171-186. Biography Jon Agirre did a degree in Computer Engineering (San Sebastian, Spain) and received a PhD in Biochemistry (Bilbao, Spain) from the University of the Basque Country in 2009, and after short stages in the Institut de Biologie Structurale Jean-Pierre Ebel in Grenoble and Institut Pasteur in Paris (2011), went on to postdoctoral research in the Department of Chemistry of the University of York, where he continued the longtime tradition of crystallographic method development at York Structural Biology Laboratory (YSBL). In 2017 he received a Royal Society University Research Fellowship to work on new methodologies for carbohydrate structure modelling, refinement, validation and representation. He is the lead author of the Privateer, Sails and Glycoblocks software, and a major contributor to CCP4i2, the new graphical user interface for the CCP4 suite of programs.

Audience: Members of the University only

Organisers: Agata Krupa

Thu 8 Nov 2018 from 13:00 to 14:00

Medical Grand Rounds

Acute General Medicine Firm A / WIMM

Acute General Medicine Firm A: -- WIMM: -- Chair: Prof Chris Conlon

Acute General Medicine Firm A: -- WIMM: -- Chair: Prof Chris Conlon

Audience: Members of the University and NHS clinical staff.

Fri 9 Nov 2018 from 08:00 to 09:00

Surgical Grand Rounds

Cricket to clinic via the lab

Professor Giles Toogood

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 9 Nov 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

When hitting one affects many - The expanding spectrum of GP130-associated Mendelian diseases

Dr Hebe Chen

Audience: Members of the University only

Organisers: Anne Farmer

Fri 9 Nov 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Stronger together: understanding pancreatic beta-cell connectivity in health and disease

Professor Guy Rutter

Persistently elevated levels of glucose and fatty acids are known to contribute to failed insulin secretion during the development of Type 2 diabetes. We have shown that glucolipotoxic conditions impair cell-cell communication (“connectivity”) to impair insulin secretion (Hodson et al, 2013).... Read more

Persistently elevated levels of glucose and fatty acids are known to contribute to failed insulin secretion during the development of Type 2 diabetes. We have shown that glucolipotoxic conditions impair cell-cell communication (“connectivity”) to impair insulin secretion (Hodson et al, 2013). Recently (Johnston et al, 2016) we have combined optogenetics and rapid Ca2+ imaging across the islet syncytium to demonstrate that a subset (~5%) of beta cells (“hubs”) coordinate the activity of “follower” cells. Photo-painting using a light sensitive-RFP revealed that hub cells are enriched for glucokinase, but show low levels of Nkx6.1 and insulin gene expression. These cells also display enhanced mitochondrial membrane potential in response to high glucose. Interrogation of single β cell RNASeq data (Xin et al PNAS, 2016) confirms the existence of a subset of cells with a similar transcriptomic configuration. Hub cells are unusually susceptible to metabolic stresses including high fatty acid/glucose levels, and cytotoxic cytokines, suggesting that they may be targeted in diabetes. Since deletion of GWAS genes for diabetes including ADCY5 and TCF7L2 affect cell-cell communication, future work will explore the possibility that genes at other loci, including STARD10 (Carrat et al, 2017) also act in part by altering hub cell-led β cell connectivity. Recent findings exploring the existence of β cell sub-populations in islets in the living animal, including zebra fish and after engraftment into the anterior chamber of the mouse eye, will also be discussed.

Audience: Members of the University only

Mon 12 Nov 2018 from 11:00 to 12:00

Department of Oncology

Old Road Campus Research Building, Meeting Rooms 71a,b,c, Headington OX3 7DQ

Title TBC

Dr Fena Ochs

Audience: Members of the University only

Organisers: Amanda O'Neill

Mon 12 Nov 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Lecture Theatre, Headington OX3 7LF

Perivascular Macrophages in Health and Disease: Their Emerging Roles in Cancer

Professor Claire Lewis

Evidence has emerged recently for a specialised subset of macrophages, those lying on the abluminal surface of blood vessels, performing an array of essential functions in steady state tissues. These include the phagocytosis of pathogens, tight control of both vascular permeability and tissue... Read more

Evidence has emerged recently for a specialised subset of macrophages, those lying on the abluminal surface of blood vessels, performing an array of essential functions in steady state tissues. These include the phagocytosis of pathogens, tight control of both vascular permeability and tissue integrity, and dampening on inappropriate inflammation. Alternatively, the aberrant activity of these perivascular sentinels contributes to the onset and/or progression of various diseases including cancer, Alzheimer’s disease, multiple sclerosis and type I diabetes. In my talk, I will outline their multifunctional role in cancer, especially their promotion of tumour repair after various forms of anti-cancer treatment (Hughes et al. 2015. Cancer Res. 75: 3479-91. Lewis et al. 2016. Cancer Cell 30:18-25). ---- After completing her DPhil in the Department of Physiology, Anatomy and Genetics in Oxford in 1986, Claire held two postdoctoral positions and a Research Lectureship in the Medical School in Oxford before moving to the Medical School in Sheffield in 1996. She currently holds a Personal Chair in Molecular & Cellular Pathology and heads a research team focussed mainly on the role of macrophage subsets in tumour responses to various anti-cancer treatments. They have also developed ways of using macrophages to target therapeutic genes and viruses to tumours (as reported by the BBC: http://www.bbc.co.uk/news/health-20795977). Her work is currently funded by grants from Cancer Research UK, Prostate Cancer UK, Breast Cancer Now, and the EU, and she sits on the editorial boards of Cancer Research, Blood, Oncoimmunology and J. Clin Invest Insight. She is a new member of the MRC’s Molecular & Cellular Medicines Board and was awarded a DSc by Oxford University in 2006 for her contribution to the field of tumour inflammation.

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Mon 12 Nov 2018 from 13:00 to 14:00

WIMM MONDAY SEMINARS

Molecular mechanisms to cope with endoplasmic reticulum stress

Prof David Ron

Audience: Members of the University only

Organisers: Liz Cloke

Mon 12 Nov 2018 from 15:00 to 16:00

BDI seminars

Big Data Institute, Old Road Campus OX3 7LF

Phenome@BDI Seminar: Parental genotypes influencing the environment

Professor Augustine Kong, Alex Young

Audience: Members of the University only

Organisers: Carol Mulligan-John

Wed 14 Nov 2018 from 12:00 to 13:00

Peter Medawar Building Seminars

Medawar Building, Level 30 Seminar Room, off South Parks Road OX1 3SY

Parallel Evolution and the Emergence of Highly Pathogenic Avian Influenza A Viruses

Dr Marina Escalera Zamudio

Surveillance of avian influenza is crucial for early detection of outbreaks in bird populations. Although virulent phenotypes are complex traits, several molecular determinants of virulence have been well characterised, such as a polybasic proteolytic cleavage site within the Hemagglutinin (HA)... Read more

Surveillance of avian influenza is crucial for early detection of outbreaks in bird populations. Although virulent phenotypes are complex traits, several molecular determinants of virulence have been well characterised, such as a polybasic proteolytic cleavage site within the Hemagglutinin (HA) protein that allows a systemic spread of the infection. We hypothesise that the parallel evolution of highly pathogenic viral lineages from low-pathogenic ancestors may have been facilitated by permissive or compensatory secondary mutations occurring anywhere in the viral genome. We developed a computational method to detect mutations associated to an evolving trait within a given phylogeny (in this case, virulence) and applied it to a phylogenetically informed sample dataset of H7NX viruses (n>300). A panel of over 30 sites strongly associated with the HP phenotype were detected. This panel may function as an early detection system for transitions between LP to HP avian viruses.

Audience: Members of the scientific community

Organisers: Professor Sunetra Gupta

please arrive 5 minutes early to gain access to the building

Thu 15 Nov 2018 from 11:00 to 12:00

Ludwig Institute Seminar Series

NDM Building, Basement seminar room, TDI, Headington OX3 7FZ

Sympathetic Neuroimmunity in obesity

Dr Ana Domingos

Audience: Members of the University only

Organisers: Christina Woodward

Thu 15 Nov 2018 from 13:00 to 14:00

Medical Grand Rounds

Radiology / Psychological Medicine

Dr Luke Solomons, Dr Ursula Schulz, Prof Fergus Gleeson

Radiology: Prof Fergus Gleeson -- Psychological Medicine: "STROKE (I63.3) OR NOT (F44.4)? What is WDZZ22", Dr Luke Solomons and Dr Ursula Schulz -- Chair: Prof Hugh Watkins

Radiology: Prof Fergus Gleeson -- Psychological Medicine: "STROKE (I63.3) OR NOT (F44.4)? What is WDZZ22", Dr Luke Solomons and Dr Ursula Schulz -- Chair: Prof Hugh Watkins

Audience: Members of the University and NHS clinical staff.

Thu 15 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

UBVO Seminar: Psychosocial inequality, insecurity and overweight/obesity in a Danish youth cohort

Per Høgh Poulsen

Audience: Members of the University only

Organisers: Graham Bagley

Thu 15 Nov 2018 from 14:00 to 15:00

Experimental Medicine TGU Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Microbial-host interactions involved in obesity and the response to bariatric surgery

Dr Carolina Arancibia, Dr Alessandra Geremia, Valentina Greto

Obesity has reached alarming levels in the UK. According to a government report, one in four adults are obese in the UK. Medical and dietary interventions are often ineffective at inducing weight loss and the best outcomes are obtained after weight loss surgery (also known as bariatric surgery).... Read more

Obesity has reached alarming levels in the UK. According to a government report, one in four adults are obese in the UK. Medical and dietary interventions are often ineffective at inducing weight loss and the best outcomes are obtained after weight loss surgery (also known as bariatric surgery). These surgical procedures were initially thought to work mechanistically through stomach restriction and lower calorie absorption through the shortened intestine. However, recent evidence has challenged this concept and it has been suggested that changes in the gut microbial flora could affect metabolism contributing to weight loss and increased insulin response. Gut flora is beneficial to the host in many ways, contributing to for example, nutrient absorption and a healthy immune system. Abnormalities in the composition of the gut microbes are thought to contribute to the pathology of certain diseases, including obesity and diabetes. The aim of this project is to find out how altered host and microbial functions affect weight loss and metabolism after bariatric surgery. Understanding more about the microbial flora and how this impacts patient’s health will hopefully make way for new approaches in the treatment of obesity and diabetes.

Audience: Members of the University only

Organisers: Dr Carolina Arancibia

Thu 15 Nov 2018 from 15:00 to 16:00

Experimental Medicine TGU Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Evaluation of the stromal compartment activation in therapy-refractory inflammatory bowel disease patients that require surgical intervention

Matthias Friedrich

Inflammatory bowel disease (IBD), in its manifestations Crohn’s disease and ulcerative colitis, is a chronic inflammatory disease that can affect all parts of the digestive tract. Environmental factors, genetic predisposition and an abnormal function of the immune system are thought to cause... Read more

Inflammatory bowel disease (IBD), in its manifestations Crohn’s disease and ulcerative colitis, is a chronic inflammatory disease that can affect all parts of the digestive tract. Environmental factors, genetic predisposition and an abnormal function of the immune system are thought to cause IBD.
Standard therapies aim at controlling intestinal inflammation and prolonging the time between disease flare-ups. Although significant progress has been made over the last decades, a high proportion of patients still do not respond to these anti- inflammatory therapies, or become resistant during the course of treatment. Failure to therapeutically control chronic inflammation can lead to severe complications in IBD patients, such as fibrosis, which requires surgical intervention. Fibrotic changes in the intestine are driven by an activation of a particular cell type, the fibroblast. The aim of this project is to find out whether IBD patients that go on to require surgery display an activation of fibroblasts, and which changes in the tissue are associated with this activation. For this, differences in the way the surgically removed fibrotic tissue is programmed will be compared to the programming of non-inflamed ‘normal’ tissue. We believe that certain alterations in this programming, which is controlled by a network of signals, can lead to changes that are specifically associated with inflammation and the requirement for surgery. Differences in the networks of signals which make up this program of inflamed and non-inflamed tissue will help us identify novel, fibroblast-targeting, therapies which will disrupt the inflammation program and hopefully reduce the requirement for surgery.

Audience: Members of the University only

Organisers: Dr Carolina Arancibia

Fri 16 Nov 2018 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Surgical Grand Rounds - ENT

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 16 Nov 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

McMichael Group

Audience: Members of the University only

Organisers: Anne Farmer

Fri 16 Nov 2018 from 10:30 to 12:00

WHG Seminars

Wellcome Trust Centre for Human Genetics, CCMP2, Headington OX3 7BN

SINGLE CELL SEMINARS - WELLCOME CENTRE FOR HUMAN GENETICS

Hannah Chen

SINGLE CELL SEMINARS - WELLCOME CENTRE FOR HUMAN GENETICS Friday, November 16, 2018 CCMP2 10:30 -12:00 Hannah Chen for info, please email curion@well.ox.ac.uk

SINGLE CELL SEMINARS - WELLCOME CENTRE FOR HUMAN GENETICS Friday, November 16, 2018 CCMP2 10:30 -12:00 Hannah Chen for info, please email curion@well.ox.ac.uk

Audience: Members of the University only

Fri 16 Nov 2018 from 12:00 to 13:00

WHG Seminars

Wellcome Trust Centre for Human Genetics, Rooms A&B, Headington OX3 7BN

An immunogenetics approach to studying immune-cell involvement in ankylosing spondylitis

Aimee Hanson

Audience: Members of the University only

Organisers: Isabel Schmidt

Fri 16 Nov 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Macrophage contribution to Insulin Resistance independently of Inflammation

Dr Myriam Aouadi

Since the discovery of macrophages in adipose tissue, many laboratories have focused their effort on understanding the contribution of these immune cells to metabolic diseases. Despite great progress in characterizing obesity as a state of low-grade inflammation, very little is known about the... Read more

Since the discovery of macrophages in adipose tissue, many laboratories have focused their effort on understanding the contribution of these immune cells to metabolic diseases. Despite great progress in characterizing obesity as a state of low-grade inflammation, very little is known about the multiple phenotypes and functions of macrophages in metabolic tissues. The lack of methods to carefully investigate cell-to-cell variability in macrophage phenotype and to manipulate gene expression in a cell-specific manner has delayed answering these crucial questions. Our lab takes advantage of sophisticated methods, such as next generation sequencing, CytOF and gene silencing in a cell specific manner, to investigate macrophage subpopulations and their function in obesity-associated metabolic complications.

Audience: Members of the University only

Mon 19 Nov 2018 from 12:00 to 13:00

OPDC Seminar Series (DPAG)

Sherrington Library, Sherrington Library, 2nd floor, off Parks Road OX1 3PT

Using transcriptomics to understand neurodegenerative disorders

Dr Mina Ryten

As an MBPhD graduate (Cambridge University & University College London) and Academic Clinical Fellow in Neurology (London Deanery), I have been lucky enough to receive training in basic research as well as clinical medicine. I have thoroughly enjoyed both and am committed to pursuing a joint... Read more

As an MBPhD graduate (Cambridge University & University College London) and Academic Clinical Fellow in Neurology (London Deanery), I have been lucky enough to receive training in basic research as well as clinical medicine. I have thoroughly enjoyed both and am committed to pursuing a joint clinical and research career in neuroscience. However, I am fully aware that the gap between clinical realities and basic research can be hard to bridge. During my PhD I investigated the role of a specific signalling system, purinergic signalling, in skeletal muscle development and regeneration under the supervision of Professor Geoffrey Burnstock (University College London). Using techniques such as cell culture, RT-PCR and immunohistochemistry, I was able to dissect out the role of an individual signalling pathway. I demonstrated that activation of the P2X5 receptor for ATP potentiated muscle stem cell differentiation and that this process was dependent on activation of the p38 MAP kinase pathway. Since my PhD the advent of high through-put microarray and sequencing-based technologies have made it possible to take a systems approach and so have the potential to provide exciting insights into complex neurological diseases. With this is in mind I have sought to develop new skills in biomedical informatics and currently hold an MRC Post-doctoral Training Fellowship in Biomedical Informatics. This fellowship has given me the opportunity to pursue my interest in the pathophysiological basis of risk genetic loci for neurodegenerative diseases and that is the focus of my current research.

Audience: Members of the University only

Organisers: Melanie Witt

PLEASE NOTE NEW TIME!

Mon 19 Nov 2018 from 12:00 to 13:00

Kennedy Institute Seminars

Kennedy Institute of Rheumatology, Bernard Sunley Theatre, Headington OX3 7LF

Title TBC

Dr Francesca Barone

Audience: Members of the University only

Organisers: Laura Sánchez Lazo

Mon 19 Nov 2018 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

Molecular determinants of dominant-negative mutations in protein complexes

Dr Joe Marsh

Audience: Members of the University only

Organisers: Liz Cloke

Tue 20 Nov 2018 from 13:00 to 14:00

Molecular Haematology Unit, WIMM

MRC Weatherall Institute of Molecular Medicine, Seminar room, Headington OX3 9DS

Title TBC

Dr Veronique Azuara

Audience: Members of the University only

Organisers: Liz Rose

Tue 20 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Wed 21 Nov 2018 from 09:15 to 10:00

WIMM Occasional Seminars

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

“How does leukemia disrupt hematopoiesis?” Viva Seminar

Audience: Members of the University only

Organisers: Sarah Butler

Viva Seminar

Wed 21 Nov 2018 from 11:00 to 12:00

Jenner Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Neo-antigen based cancer vaccines

Prof Alfredo Nicosia

Audience: Members of the University of Oxford and The Pirbright Institute

Organisers: Lisbeth Soederberg

Wed 21 Nov 2018 from 12:00 to 13:00

Peter Medawar Building Seminars

Medawar Building, Level 30 Seminar Room, off South Parks Road OX1 3SY

Adapting protein quality control for intervention in immunity and neurodegenerative diseases

Heidi Olzscha

Protein folding is tightly regulated by molecular chaperones and other protein quality control mechanisms such as the ubiquitin proteasome system and autophagy to ensure the integrity of the proteome. However, these systems can fail to prevent protein misfolding, leading to protein aggregation and... Read more

Protein folding is tightly regulated by molecular chaperones and other protein quality control mechanisms such as the ubiquitin proteasome system and autophagy to ensure the integrity of the proteome. However, these systems can fail to prevent protein misfolding, leading to protein aggregation and amyloidosis. They are underlying reasons for many neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease or Huntington’s disease. Interfering with protein quality control systems and modulating posttranslational modifications of proteins can reduce aggregation, ameliorate amyloidosis and can have profound effects on the immune system.

Audience: Members of the scientific community

Organisers: Professor Sunetra Gupta

please arrive 5 minutes before the seminar to gain entry to the building

Wed 21 Nov 2018 from 13:00 to 14:00

John Radcliffe Hospital, Lecture Theatre 2, Academic Centre

Litchfield Lecture 2018: Basic to Clinical: A translational journey in parasitology and beyond

Professor Mike Ferguson

Audience: All Academic, clinical and support staff, all Graduate and Medical students

Organisers: Kathryn Smith

Thu 22 Nov 2018 from 13:00 to 14:00

Medical Grand Rounds

Tropical Medicine Day

Tropical Medicine: -- Tropical Medicine: -- Chair: TBA

Tropical Medicine: -- Tropical Medicine: -- Chair: TBA

Audience: Members of the University and NHS clinical staff.

Thu 22 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

UBVO Seminar: Assessing the reformulation efforts of soft drinks companies in the UK

Lauren Bandy

Audience: Members of the University only

Organisers: Graham Bagley

Fri 23 Nov 2018 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Surgical Grand Rounds - Urology

Professor Declan Murphy

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 23 Nov 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Spontaneous and targeted disruption of thymus development and function: Lessons learnt

Wei Wu, Ioanna Rota, Prof Georg Holländer, Stanley Cheuk

Audience: Members of the University only

Organisers: Anne Farmer

Fri 23 Nov 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

GL Brown Lecture (PhySoc) - Seeing depth with two eyes: the binocular physiology of 3D space

Progessor Andrew Parker

Neurons that are specifically tuned to binocular depth were discovered in seminal work published 50 years ago by Horace Barlow, Colin Blakemore and Jack Pettigrew in the Journal of Physiology. Their study in the primary visual cortex opened up the era of understanding the physiology of 3-D... Read more

Neurons that are specifically tuned to binocular depth were discovered in seminal work published 50 years ago by Horace Barlow, Colin Blakemore and Jack Pettigrew in the Journal of Physiology. Their study in the primary visual cortex opened up the era of understanding the physiology of 3-D perception. Thanks to more recent work, we now know that large areas of the extrastriate visual cortex are involved. Sites where binocular stereoscopic depth is integrated with other visual information can be identified and physiological signals related to active perceptual decisions about depth can be isolated. At some sites, a causal role of physiological signals for the perception of depth can be demonstrated by showing that weak electrical microstimulation of the cortex can alter behavioural reports of depth perception. However, there seems to be no single brain module that is responsible for computing stereoscopic depth. This lecture will trace these paths of discovery in human and animal studies. Andrew Parker will show how a better understanding of the physiology of depth perception changes our view of how the brain constructs a representation of the space around us. Findings from this neurophysiological research have implications for the growing popularity of 3-D cinema and immersive virtual reality.

Audience: Members of the University only

Mon 26 Nov 2018 from 12:30 to 13:30

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

NPEU Seminar - Stillbirth: Death by another name

David Monteith

Audience: Members of the University only

Organisers: Graham Bagley

Mon 26 Nov 2018 from 13:00 to 14:00

WIMM MONDAY SEMINARS

MRC Weatherall Institute of Molecular Medicine, Seminar Room, Headington OX3 9DS

JAK/STAT signalling, stem cell subversion

Professaor Tony Green

Audience: Public

Organisers: Linda Roberts

Mon 26 Nov 2018 from 15:00 to 16:00

BDI seminars

Big Data Institute, Seminar room 0, Old Road Campus OX3 7LF

Phenome@BDI Seminar: Cancer phenotyping

Dr David Wedge, Dan Woodcock

Audience: Members of the University only

Organisers: Carol Mulligan-John

Tue 27 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

Richard Doll Seminar: Using naturally randomized genetic evidence to inform the design of randomized trials

Professor Brian Ference

Brian is a cardiologist and genetic epidemiologist who was educated and trained at Harvard, Yale, Oxford and Cambridge Universities. He graduated from Yale Medical School, and trained in clinical epidemiology and genetic epidemiology at Yale. He then trained in cardiology and interventional... Read more

Brian is a cardiologist and genetic epidemiologist who was educated and trained at Harvard, Yale, Oxford and Cambridge Universities. He graduated from Yale Medical School, and trained in clinical epidemiology and genetic epidemiology at Yale. He then trained in cardiology and interventional cardiology at Harvard Medical School where he also completed the Program in Clinical Effectiveness at Harvard School of Public Health, and was an NHLBI Cardiovascular (Genetic) Epidemiology Fellow. He is currently Director of Research in Translational Therapeutics, and Head of the Centre for Naturally Randomized Trials in Cambridge having moved from Wayne State University School of Medicine in Detroit where he was Clinical Chief of Cardiology and Director of the Cardiovascular Genomic Research Centre. His research focuses on using Mendelian randomization to design ‘naturally randomized trials’ to generate evidence that can be used to improve the drug discovery and development process; inform the optimal design of trials; fill evidence gaps when a randomized trial is not possible or practical; and define the practice of precision cardiovascular medicine.

Audience: Members of the University only

Wed 28 Nov 2018 from 12:00 to 13:00

Peter Medawar Building Seminars

Medawar Building, Level 30 Seminar Room, off South Parks Road OX1 3SY

Host MHC and genomic diversity retards experimental evolution of viral virulence

Proffesor Wayne Potts

Experimental evolution of a mouse-specific retrovirus in various host genotypes reveal increases in fitness and virulence by 50- and 20-fold respectively. The virus adapts to specific host genotypes as indicated by its’ reduced ability to infect other host genotypes, including those that differ... Read more

Experimental evolution of a mouse-specific retrovirus in various host genotypes reveal increases in fitness and virulence by 50- and 20-fold respectively. The virus adapts to specific host genotypes as indicated by its’ reduced ability to infect other host genotypes, including those that differ only at histocompatibility loci. Three round serial passages where the host genotype is alternated once, dramatically reduces viral fitness and virulence. Full genome sequencing of these evolved viral lines reveal surprising results where no mutations have become fixed despite strong selection operating over 240 generations.

Audience: Members of the scientific community

Organisers: Professor Sunetra Gupta

Please arrive 5 minutes before the seminar to gain access to the building

Thu 29 Nov 2018 from 13:00 to 14:00

Medical Grand Rounds

Jenner Institute / Silver Star

Prof Adrian Hill, Dr Samantha Chessell, Dr Lauren Green, Dr Charlotte Frise

Jenner Institute: "Therapeutic Vaccines", Prof Adrian Hill -- Silver Star: "Baby, you take my breath away: A presentation on breathlessness in pregnancy", Dr Samantha Chessell, Dr Lauren Green and Dr Charlotte Frise -- Chair: Prof Hugh Watkins

Jenner Institute: "Therapeutic Vaccines", Prof Adrian Hill -- Silver Star: "Baby, you take my breath away: A presentation on breathlessness in pregnancy", Dr Samantha Chessell, Dr Lauren Green and Dr Charlotte Frise -- Chair: Prof Hugh Watkins

Audience: Members of the University and NHS clinical staff.

Thu 29 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre , Old Road Campus OX3 7LF

Richard Doll Seminar: Can we transform perinatal care through larger, more efficient, collectively prioritised international trials?

Professor William Tarnow-Mordi

William is an academic neonatologist, who graduated with first class Honours in Cambridge. He has a globally recognised record of translational research via international multicentre RCTs and cohort studies in >30,000 patients and >200 neonatal units worldwide. Having trained in neonatal medicine... Read more

William is an academic neonatologist, who graduated with first class Honours in Cambridge. He has a globally recognised record of translational research via international multicentre RCTs and cohort studies in >30,000 patients and >200 neonatal units worldwide. Having trained in neonatal medicine in the UK, he moved to Sydney in 1999 as inaugural Chair of Neonatology at Westmead Hospital, University of Sydney and Director of Neonatology. He has been a strong advocate of large multicentre neonatal and perinatal studies to answer key clinical questions and has conducted multiple landmark collaborative studies such as the International Neonatal Immunotherapy Trial, the ECSURF Study, the UK Neonatal Staffing Study, INIS, BOOST II Australia, the Australian Placental Transfusion Study (APTS) of delayed cord clamping and the NeOProM Collaboration of oxygen saturation. Each has contributed to evidence that is likely to save millions of lives in coming years. This raises a new challenge: “In the next decade, can parents, patients, professionals, researchers, policymakers, providers, funders and the public collaborate to embed international trials in routine care that are ten times larger and faster, at one tenth the cost?”

Audience: Members of the University only

Thu 29 Nov 2018 from 13:00 to 14:00

Population Health Seminars

Richard Doll Building, Lecture Theatre, Old Road Campus OX3 7LF

UBVO Seminar: Genomics of common obesity

Cecilia Lindgren

Audience: Members of the University only

Organisers: Graham Bagley

Fri 30 Nov 2018 from 08:00 to 09:00

Surgical Grand Rounds

John Radcliffe Academic, Lecture Theatre 1, Headington OX3 9DU

Surgical Grand Rounds - Transplant

Professor Peter Friend, Dr David Nasralla

Audience: Members of the University only

Organisers: Tarryn Ching

Fri 30 Nov 2018 from 09:15 to 10:15

MRC HIU Friday Morning Lab Meetings

MRC Weatherall Institute of Molecular Medicine, WIMM Seminar Room, Headington OX3 9DS

Title TBC

Ogg Group

Audience: Members of the University only

Organisers: Anne Farmer

Fri 30 Nov 2018 from 13:00 to 14:00

DPAG Head of Department Seminar Series

Sherrington Building, Large Lecture Theatre, off Parks Road OX1 3PT

Coping with a stressful start in life

Professor Alex Gould

Joint Seminar with the Dunn School Environmental stresses experienced during development (early-life) exert both short and long-term influences upon health and disease. In most cases, however, the underlying biological response mechanisms remain mysterious. The goal of our research is to... Read more

Joint Seminar with the Dunn School Environmental stresses experienced during development (early-life) exert both short and long-term influences upon health and disease. In most cases, however, the underlying biological response mechanisms remain mysterious. The goal of our research is to understand the molecular nuts and bolts of how early-life environmental stresses alter gene expression, metabolism and physiology. Much of our research uses the powerful genetics of the fruit fly Drosophila, together with analytical techniques such as metabolomics and mass spectrometry imaging. Using this combined approach, we identified molecular mechanisms that protect neural stem cells in the developing CNS from the immediate harmful effects of malnutrition and hypoxia. For example, we found that hypoxia induces lipid droplets in the local microenvironment (niche) of the neural stem cells. Droplets function to protect neural stem cells from lipid peroxidation damage, likely by sequestering potentially vulnerable polyunsaturated fatty acids in their core. We have also begun investigating the longer-term impact of early-life stresses upon longevity. Recent work shows that developmental exposure to mild oxidative or nutritional stress can, in some cases, extend rather than shorten lifespan. I will discuss the surprising mechanisms that account for stress-induced longevity and the degree to which they may be conserved between flies and mammals.

Audience: Members of the University only