||Address:||The Jenner Institute, Old Road Campus Research Building
Roosevelt Drive, Oxford, OX3 7DQ
|Tel:||+44 (0)1865 617639|
|Principal areas of research:||A vaccine against blood stage plasmodium vivax|
Tom is a physician training in Infectious Diseases & Microbiology and a Wellcome Trust Research Training Fellow at The Jenner Institute. His DPhil research, as part of the blood-stage malaria team, is focused on developing an effective vaccine against Plasmodium vivax malaria. This species of malaria, despite being the most globally widespread of the human malarias and responsible for a huge morbidity burden, has been historically overlooked by researchers.
One approach in Tom's project is to isolate a panel of human monoclonal antibodies (mAbs) against the leading blood-stage vivax vaccine antigen, from volunteers in the recent vivax vaccine trial. Through structural studies on the most potent and broadly neutralising of these mAbs in complex with the antigen he hopes to define critical binding sites and enable structure-guided immunogen design.