Dr Nicola Ternette

Dr_Nicola_Ternette
Address: Target Discovery Institute, NDM Research Building
Roosevelt Drive, Oxford, OX3 7DQ
Tel: +44 (0)7517 618652
Email: nicola.ternette@ndm.ox.ac.uk
Principal areas of research: Proteomics, HIV-1 T-cell vaccines

Research

T-cell mediated immunity is reliant on the nature of the HLA-associated peptide pool presented on an infected cell or in tumour tissue. The specificity of this presentation determines the quality of the immunological response that can be elicited by cellular immune responses. My research focuses on qualitative and quantitative characterization of these cellular immunopeptidomes in the context of pathogen infection and cancer using mass spectrometry.

This work is highly relevant for identification and specification of novel targets for vaccine design.

Key Publications

Ternette N*, Yang H*, Partridge T, Llano A, Cedeño S, Fischer R, Charles PD, Dudek NL, Mothe B, Crespo M, Fischer WM, Korber BT, Nielsen M, Borrow P, Purcell AW, Brander C, Dorrell L, Kessler BM, Hanke T. Defining the HLA Class I-Associated Viral Antigen Repertoire from HIV-1-Infected Cells. Eur J Immunol. 2015 Oct 15. doi: 10.1002/eji.201545890

Caron E, Espona L, Kowalewski DJ, Schuster H, Ternette N, Alpízar A, Schittenhelm RB, Ramarathinam SH, Lindestam Arlehamn CS, Chiek Koh C, Gillet LC, Rabsteyn A, Navarro P, Kim S, Lam H, Sturm T, Marcilla M, Sette A, Campbell DS, Deutsch EW, Moritz RL, Purcell AW, Rammensee HG, Stevanovic S, Aebersold R. An open-source computational and data resource to analyze digital maps of immunopeptidomes. eLife. 2015 Jul 8;4. doi: 10.7554/eLife.07661.

Ternette N, Block P, Sánchez Bernabéu Á, Borthwick N, Pappalardo E, Abdul-Jawada, S, Ondondo, Charles PD, Dorrell L, Kessler BM, Hanke T. Early kinetics of HLA class I-associated peptidome of MVA.HIVconsv-infected cells. J Virol.2015 Jun;89(11):5760-71. doi: 10.1128/JVI.03627-14

Chappell P, Meziane el K, Harrison M, Magiera Ł, Hermann C, Mears L, Wrobel AG, Durant C, Nielsen LL, Buus S, Ternette N, Mwangi W, Butter C, Nair V, Ahyee T, Duggleby R, Madrigal A, Roversi P, Lea SM, Kaufman J. Expression levels of MHC class I molecules are inversely correlated with promiscuity of peptide binding. eLife. 2015 Apr 10;4. doi: 10.7554/eLife.05345.

Yang M*, Ternette N*, Su H, Dabiri R, Kessler BM, Adam J, Teh BT, Pollard PJ. The Succinated Proteome of FH-Mutant Tumours. Metabolites. 2014 Aug 7;4(3):640-54.

Chen L, Fischer R, Peng Y, Reeves E, McHugh K, Ternette N, Hanke T, Dong T, Elliott T, Shastri N, Kollnberger S, James E, Kessler B, Bowness P. Critical role of endoplasmic reticulum aminopeptidase 1 in determining the length and sequence of peptides bound and presented by HLA-B27. Arthritis Rheumatol. 2014 Feb;66(2):284-94.

Ternette N*, Yang M*, Laroyia M, Kitagawa M, O’Flaherty L, Wolhulter K, Igarashi K, Saito K, Kato K, Fischer R, Berquand A, Kessler BM, Lappin T, Frizzell N, Soga T, Adam J, Pollard PJ. Inhibition of Mitochondrial Aconitase by Succination In Fumarate Hydratase Deficiency. Cell Reports. 2013 Mar 28;3(3):689-700.