Dr Giacomo Gorini

 
Dr Giacomo Gorini

Address:

The Jenner Institute, Old Road Campus Research Building

Roosevelt Drive, Oxford, OX3 7DQ

Email: giacomo.gorini@ndm.ox.ac.uk

Principal areas of research:

Antibodies, vaccines, malaria

Research

The development of an effective vaccine to prevent infection by Plasmodium falciparum, the causative agent of the majority of global malaria mortality and morbidity, is a global priority.

Vaccine-induced antibody responses have led to protection against many pathogens that pose a human health risk. Unfortunately, because of the variability in the proteins expressed by Plasmodium, as well as the complicated life cycle of this parasite, the development of an effective vaccine remains elusive.

Our group is now testing a vaccine that is designed to elicit immune responses against RH5, a highly conserved blood stage antigen of P. falciparum. We aim to isolate a large panel of RH5-specific human monoclonal antibodies (mAbs) from vaccinees to study the quality of the vaccine-induced IgG antibody response, and to inform our understanding of the response that determines antibody-mediated immunity against P. falciparum.

Functional and structural characterisation of the isolated mAbs will be used to identify critical epitopes on the RH5 molecule to guide next-generation vaccine immunogen design.